Articles Related to Transplantation

Alport Syndrome is a hereditary condition that affects the collagen in the basement membrane and is characterized by microscopic hematuria, sensorineural hearing loss, increasing renal dysfunction, and ocular abnormalities. It is more common between the ages of 20 and 30. Men and women are equally affected. However, the prognosis of men is worse than women due to renal failure. The purpose of this study is to evaluate the demographic and clinical findings of patients with Alport Syndrome in our center

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Bloodstream infections (BSI) are one of severe infectious complications faced by hematopoietic stem cell transplantation (HSCT) patients. BSI increases significantly the morbidity and mortality of HSCT patients. Gram-positive bacteria occurred more frequency than gram-negative bacteria over past decades, but rates of gram-negative bloodstream infections have recently increased again. Antibacterial prophylaxis could be justified in HSCT, infections caused by resistant pathogens increased mortality. New antibiotics such as omadacycline, meropenem/vaborbactam, eravacycline, ceftobiprole, tedizolid, dalbavancin, cefiderocol hold promise for the treatment of highly resistant pathogens.

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The choice of induction immunosuppression can affect several outcomes after kidney transplant (KTx). We aimed to evaluate infectious and malignant complications between alemtuzumab and basiliximab in elderly KTx recipients. Patients ≥ 65 years old who received alemtuzumab or basiliximab induction for their primary KTx from 2006 – 2018 were included.

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The research is comparative descriptive type. The sample of the study consisted of a total of 167 people, including 82 hemodialysis patients and 85 healthy individuals who applied to the Family Health Center. The data of the study were obtained using the questionnaire and organ donation attitude scale. SPSS 25 was used in the analysis of the data.

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We report a unique case of a male recipient who received a zero mismatch kidney with mild anatomical anomalies from his sister. This right kidney was malrotated, had an extra renal pelvis with moderately dilated ureter up to the iliac artery bifurcation. Immediate graft function was achieved on reperfusion, and the recipient was discharged on day 7 with a serum creatinine (SC) of 1.8mg/dl. The DJ stent was removed after 6 weeks, with a rapid increase in SC to 3.5mg/dl, and ultrasound showed mild hydronephrosis with delayed excretion on nuclear imaging. Mechanical obstruction was excluded by retrograde pyelography, and a 5F DJ stent was placed across the ureterovesical anastomosis with an immediate decrease in SC. The case is presented in detail and discussed in the light of the current literature.

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Stem cells are relatively undifferentiated, with unlimited proliferative ability; self-renewal capability and also they can differentiate into specialized cells. Somatic stem cells in adult organisms are responsible for regenerating and self-renewing tissue. Many different stem cell types reside in the eye.

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Allogeneic transplantation (Allo-SCT) in multiple myeloma is controversial mainly due to the relatively high non-relapse mortality (NRM). The aim with this retrospective single-center study was to evaluate recent transplants particularly after conditioning with treosulfan plus fludarabine (TreoFlu).

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We report here for the first time the efficacy of pegylated interferon α2a (Peg-Ifn) as a therapy for patients with myelofibrosis and high blast counts. We treated four patients who were in an accelerated phase of myeloproliferative neoplasms or acute panmyelosis with myelofibrosis using only this drug.

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Cardiac retransplantation is the standard treatment for patients with advanced graft vasculopathy. It remains controversial due to the scarcity of donors and poor results when compared with the novo transplant.

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Assisted reproductive technologies, such as artificial insemination and embryo transfer, have produced significant outcomes in cattle. These technologies are useful not only for improving fertility but also for increasing the rate of genetic change in beef and dairy livestock. Today, embryo transfer in cattle is both practical and commercially viable. However, bovine embryo transplantation still remains suboptimal under on-farm conditions, one of the main reasons for which may be inefficient nutritional management.

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Dilated Cardiomyopathy is the most common form of the cardiomyopathies in children accounting for a significant cause of morbidity and mortality as well as a common indication for heart transplant.

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Seventeen alpha hydroxyprogesterone caproate (17-OHPC) is the only FDA-approved drug labeled for prevention of preterm delivery. This drug is also available as a compounded product from licensed compounding pharmacies. This article reviews the FDA approval history and pharmacy compounding quality control data of 17-OHPC, as well as briefly discusses possible future pharmaceutical development strategies for 17-OHPC.

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