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Articles Related to Treatment

Predictive Value of ERCC1 Expression on Treatment Response to Cisplatin-Based Regimens in Small Cell Lung Cancer: A Retrospective Analysis

We aimed to determine whether the excision repair cross-complementation group 1 (ERCC1) expression predicts response to cisplatin-based chemotherapy in patients with small cell lung cancer (SCLC). This was a retrospective study, in which hospital files of 31 patients (29 males, 2 females; mean age, 62.26±7.71 years) were reviewed. All patients were treated with etoposide+cisplatin. The lung biopsy and mediastinal lymph node samples were applied anti-human monoclonal antibodies against ERCC1: immunohistochemical staining was considered positive if 25-100% of the cells showed nuclear staining, and negative if less than 25% of the cells showed negative or slight staining. Response to treatment was evaluated as regression (complete or partial response), progressive disease, or stable disease. Of the patients, 18 (58.1%) had limited-stage, and 13 (41.9%) had extensive-stage SCLC. Median follow-up duration was 15 months (range: 1-60 months). ERCC1 staining was positive in 9 of 31 patients (29.0%). In 12 patients (38.7%), tumor regression (complete or partial response) was obtained after chemotherapy. Tumor regression rate was higher in ERCC1 positive patients than those with negative ERCC1 expression (66.7% vs. 27.3%, p=0.036). In conclusion, high expression of ERCC1 was associated with higher response rate to cisplatin-based regimens in patients with SCLC.
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A Clinical Case Study of Paratesticular Rhabdomyosarcoma of Young Adult

Para-testicular rhabdomyosarcoma (RPT) is a rare tumor of children and adolescents. The diagnosis is made by the anatomopathological study. The treatment must be multimodal and involves surgery, chemotherapy and radiotherapy. We report the case of a 19-year-old adolescent in our department for an embryonic-type para-testicular rhabdomyosarcoma. Our aim is to expose a rare and unknown case that may be life-threatening. We would like to emphasize on the fact that paratesticular rhabdomyosarcoma need to be brought up in front of a tissular process expanding in the scrotum with normal testicules.
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Hydroxyapatite Deposition Disease- Spontaneous Resolution of Significant Post Treatment Deposit

Calcific deposits are commonly seen on imaging done for other reasons. However, it can also present with periarthritis and adhesive capsulitis leading to severe disabling pain. Many theories have been proposed to explain the etiology and it is considered idiopathic by some. The management is also debatable, Barbotage being the most popular. In the majority of the cases it disappears spontaneously, requiring intervention like Barbotage and surgery only in a few cases. We present a case of a 45 year old female patient who had these calcific deposits in an unusual location of her right shoulder. These disappeared partially on conservative treatment. Subsequently, she developed severe pain in her right shoulder with restriction of all her movements. The pain was severe enough to interfere with her sleep. As a result she underwent barbotage. During the procedure an attempt was made to aspirate the calcific deposit in its entirety. This was not possible due to clogging of needle several times. There was complete resolution of pain following the procedure. However, post- procedure Magnetic resonance imaging (MRI) revealed a significant residual calcification which completely resolved 02 months after therapy with no recurrence.
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Sedoanalgesia During Dental Treatment of a Patient with Sanfilippo Syndrome: A Case Report

Sanfilippo syndrome, a type of mucopolysaccharidosis (MPS), is an autosomal recessive lysosomal storage disease. The disorder is characterized by bone abnormalities (i.e. abnormally long arms and legs when compared with the trunk length), as well as abnormal bone shapes and skin thickening.In general, patients with Sanfilippo syndrome have sharp and coarse facial features, thickening of the lips and enlargement of the mouth and tongue. Hypoplasia of hard dental tissue is also present. The parents of a 5-year-old female patient were referred to Konya Oral and Dental Health Hospital because of tooth pain. A full dental examination could not be conducted because the patient was not cooperative. Thus, we decided to perform the patient’s treatment under general anaesthesia. As the patient had a history of difficult intubation and the planned dental procedures could be completed in a short time, under sedoanalgesia.
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The Effect of Salbutamol Nebul Treatment on Systolic Pulmonary Artery Pressure in Newly Diagnosed Patients with Chronic Obstructive Pulmoner Disease

The occurrence of pulmonary hypertension [PHT] in patients with chronic obstructive pulmoner disease [COPD] usually indicates progression of the disease and poor prognosis. The aim of this study is to investigate the effect of oxygen and bronchodilator treatment on systolic pulmonary artery pressure induced by exertion test in patients with COPD.
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Treatment of Moderate Fluorosis with Combined Bleaching Protocols

The patient’s concern was the appearance of her maxillary and mandibular teeth, which had a mottled, brown-yellow enamel dysmineralization due to moderate fluorosis. The patient was 45 years old, and lived in Isparta region where drinking water has high concentration of Fluoride ion. Patient was a female doctor and was concerned that the appearance of her teeth would negatively impact interactions with her patients and social life.
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Modified and Combined Lateral and Posterolateral Approach an Alternative Treatment to Tibial Plateau Fractures

The selection of a surgical approach for the treatment of tibia plateau fractures is an important decision. Approximately 7% of all tibia plateau fractures affect the posterolateral corner. Displaced posterolateral tibia plateau fractures require anatomic articular reduction and buttress plate fixation on the posterior aspect. These aims are difficult to reach through a lateral or anterolateral approach. The standard posterolateral approach with fibula osteotomy and release of the posterolateral corner is a traumatic procedure, which includes the risk of fragment denudation. Isolated posterior approaches do not allow sufficient visual control of fracture reduction, especially if the fracture is complex. Therefore, the aim of this case report was to present a surgical approach for posterolateral tibial plateau fractures that both protects the soft tissue and allows for good visual control of fracture reduction. The approach involves a lateral arthrotomy for visualizing the joint surface and a posterolateral approach for the fracture reduction and plate fixation, which are both achieved through one posterolateral skin incision. Using this approach, we achieved reduction of the articular surface and stable fixation in patients at the final follow-up visit. No complications and no loss of reduction were observed. Additionally, the new posterolateral approach permits direct visual exposure and facilitates the application of a buttress plate. This approach does not require fibular osteotomy, and fragments of the posterolateral corner do not have to be detached from the soft tissue network.
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Management Protocol for Patients with Down syndrome associated with Alzheimers disease

Down syndrome is one of the most common chromosomal alterations and due to the incremental in the oval life expectancy and its relationship with Alzheimer disease; the professionals have to be aware of the oral and behavioral characteristics to give patients an excellent treatment.
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Artisanal Cannabis in Young and Adults Patients with Treatment Resistant Epilepsy: Prospective, Observational, Open-Label Study in Argentina

Background: A third of patients with epilepsy have a drug-resistant form. We aimed to observed whether addition of artisanal cannabis to existing anti-epileptic treatment would be safe, and efficacious in young and adults with drug-resistant epilepsy. Methods: Patients (aged 12-51 years) with severe, intractable epilepsy, who were receiving stable doses of antiepileptic drugs before study entry, were enrolled in an expanded-access programme at our epilepsy centre.
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Monotherapy versus Combination Therapy for the Treatment of Pseudomonas Aeruginosa in Cystic Fibrosis Patients

Infection with Pseudomonas aeruginosa in cystic fibrosis (CF) patients is a strong contributor to respiratory failure and associated mortality. Bacteria colonizing a cystic fibrosis lung commonly form biofilms that greatly contribute to increased antibiotic resistance and hypermutability. Antimicrobial treatment in these cases can be either through the use of a single agent (monotherapy) or through a combination of agents (combination therapy).
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Quality of Life after Accidental Major Vascular Injury and Prolonged ICU Stay - A Case Report

Survival or mortality rate is a reasonable choice of an outcome measure for critically ill patients in intensive care unit (ICU). But it is also important to assess the impact of critical illness and peri-operative complications on health status and quality of life (QoL) after hospital discharge. The QLQ-C30 is a 30-item cancer-specific questionnaire that incorporates five functioning scales (physical, role, cognitive, emotional, and social), eight symptoms scales, perceived financial impact of the disease and a global scale [1-5].
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Benign Pulmonary Metastasizing Leiomyoma

Benign metastasizing leiomyoma (BML) is a rare event that occurs in middle aged women with a history of uterine myomas. It is characterized by multiple leiomyomatous lesions in many tissues and organs, especially in the lungs. We report the case of 56 years old woman presenting chronic cough, hemoptysis and having a history of myomectomy for a uterine leiomyoma 6 years ago. Chest CT showed a right pulmonary process. The histological diagnosis was defined by bronchoscopy and biopsies. The surgery was not an option because of the bronchovascular extension of the tumor, so hormonal therapy was administrated to the patient. One year later, Chest CT showed that the tumor doesn’t increase.
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Caenorhabditis elegans (C. elegans) Used as a Whole Model Organism to Identify New Anti-Infectives Therapeutic Agent for MRSA Pathogens - A Review Paper

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the greatest fears with the number of serious infections on human health regarding antibiotic resistance. It causes a wide range of infections and bacteremia, ranging from inconsequential superficial skin infections, wound suppuration, even pneumonia or deep-seated tissue infections, which may lead to sepsis and fatalities.
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Rebleeding In Central Nervous System after Use of Rivaroxaban for Treatment of Deep Venous Thrombosis in a Patient with Cerebral Vasculitis

Introduction: Rivaroxaban is a direct, specific inhibitor of Factor Xa, which targets Factor Xa and Factor Xa free and coagulated in the prothrombinase complex. Objective: To report a case of CNS rebleeding after using Rivaroxaban for treatment of DVT
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Novel Alternative Treatment to Plasmapheresis in Evans Syndrome

Evans syndrome is a rare haematological disease characterised by concurrent occurrence of autoimmune haemolytic anaemia (AIHA) and idiopathic thrombocytopenic purpura. The autoimmune haemolysis can lead to hyperbilirubinaemia, profound anaemia and haemodynamic instability. It can be difficult to treat and when refractory to medical treatment it could necessitate emergency splenectomy. Plasmapheresis is used in refractory haemolytic anaemia to aid removal of disease causing autoimmune complexes whilst immunomodulators act to reduce autoantibody response and effectiveness. However, this is an expensive and resource intensive process that is limited to tertiary referral centres. In this case study we present a successful novel alternative for life threatening AIHA in Evans Syndrome using haemofiltration with on-going fresh frozen plasma transfusion when resources are limited or it is not an accessible method.
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Editorial Board Members Related to Treatment

Martin A. Katzman

Clinic Director and Staff Psychiatrist
START Clinic for Mood and Anxiety Disorders
Canada

JOHN EVANS

Professor
Department of Obstetrics and Gynaecology
University of Otago
New Zealand

Jonathan Scott Harrison

Professor
Division of Hematology/Medical Oncology University of Missouri
United States

RICHARD K. GILROY

Professor of Medicine
Medical Director of Liver Transplantation
Department of Gastroenterology and Hepatology
University of Kansas Medical Center
United States

Mojahid-ul-Islam

Professor
Department of Pharmaceutical Chemistry
Lloyd Institue of management and Tech
India

Zhiyuan Li

Professor
Laboratory of Ion Channels Research
Guangzhou Institute of Biomedicine and Health
Chinese Academy of Sciences
China

Xujie Lu

Professor
School of tropical eco-environment protection
Hainan tropical Ocean University
China

Shubiao Wu

Associate Professor
Aarhus Institute of Advanced Studies
Aarhus University
Denmark

GHASSAN M. MATAR

Professor
Department of Experimental Pathology, Immunology & Microbiology
Faculty of Medicine
American University of Beirut
Lebanon

MICHAEL VAN DOREN JOHNSTON

Professor
Department of Neurology and Pediatrics
Johns Hopkins University School of Medicine
United States
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