Articles Related to Tumor

Superficial CD34-positive fibroblastic tumor is an infrequent soft-tissue tumor characterized by a lesion located in the subcutaneous fascia without affecting the soft or deep muscle planes. Its incidence is unknown; therefore, it represents a diagnostic challenge for both the surgical oncologist and pathologist. Given its high risk of local recurrence, extensive surgical resection is the recommended treatment modality. This is the first report of this rare entity in Latin-America.

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Enteric fever is a common infection of tropical countries that can have a variety of neurological complications. Reported neurological complications are encephalopathy, eningism, spastic paralysis-cerebral origin, convulsions, meningitis, parkinsonian syndrome, sensory motor neuropathy, cerebellar involvement, and schizophrenic psychosis. The patient, who was diagnosed with enteric fever and started treatment, developed headache and blurred vision 5 days after the treatment. Cerebral venous sinus thrombosis secondary to enteric fever and related pseudotumor cerebri were detected in the patient. When additional symptoms develop despite treatment in patients with enteric fever, complications such as thrombosis and pseudotumor cerebri should be considered.

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Background: Limited data on large cohort of patients with malignant tumors of the scalp are available in the literature. The aim of this study was to review a large cohort of patients with malignant scalp tumors to determine epidemilogy, tumor characteristics of this region and treatment. Materials and Method: A retrospective review of patients with malignant scalp tumors diagnosed histopathologically between 2005 and 2021 was performed. Demographic features and tumor characteristics were analyzed. Results: A total of 1080 patients (M: F 3,5:1) were treated and followed up for a mean period of 42 months (12-120 months). Age at diagnosis ranged from 12 to 98 years. Most malignant scalp tumors (95,1%) occurred in those 50 years or older and in bald patients (87%). Basal cell carcinomas (59,2%), squamous cell carcinomas (32,2%) and melanomas were the most common histologic types. Incidence was highest on the frontal of temporal region (66,1%). Recurrence was frequently in squamous and basal cell carcinomas but uncommon in melanoma. Conclusions: Tumors of the scalp accounted about 8,01 % of all skin cancers. Tend to be basal and squamous cell carcinomas, many of which occur in the temporal and frontal region of bald men. The outlook for patients with scalp tumor is positive, although we suggest excision margins of at least 3-4 mm and continued clinical vigilance is warranted given their higher recurrence rates.

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Pediatric cancer overall survival has increased due to improvements in treatment. However, long-term adverse effects are a challenge for this population. Secondary myeloid neoplasm (MN) is one of the complications of solid tumor treatment. Therapy-related myeloid neoplasms (t-MN), therapy-related acute myeloid leukemia (t-AML), and therapy-related myelodysplastic syndrome (t-MDS) are the most common events. The aim of this study was to report a large pediatric sample and the relevance of t-MN after pediatric solid tumor therapy. We conducted a retrospective study between 2000-2016 in a cohort of pediatric patients treated for solid tumors who developed a secondary MN by medical records review and analysis. Seven from 2178 pediatric patients who were previously treated for solid tumors, were diagnosed with t-MN in a reference cancer center in Brazil. The median age at primary tumor diagnosis was 12.8 years old. Osteosarcoma, atypical primitive neuroectodermal tumor (PNET), Ewing sarcoma, and retinoblastoma were the most frequent solid tumors associated with t-MN. Three patients had a story of familiar cancer, and one patient with osteosarcoma had Li-Fraumeni syndrome confirmed. The median latency period to secondary MN was ten months and the prevalence rate was 0.32%. Two patients developed t-MDS and five, t-AML. All these patients received cytotoxic agents’ high doses that may have been associated with t-MN development. t-MN initial control, as well as unfavorable cytogenetic abnormalities, may have contributed to the poor outcome. We described the rarity of t-MN related to previous solid tumor therapy in a large pediatric sample in a Brazilian Cancer Center and their poor prognosis.

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Peripheral giant cell granuloma (PGCG) is a rarely seen benign lesion at soft oral tissue. In this report, the patient had a history of central giant cell granuloma at the left mandibular posterior region. The lesion was excised two years ago. Patient was consulted to our hospital for soft tissue growth at right maxillary anterior region. Excisional biopsy was planned and the lesion was examined histopathologically. Giant cell reparative granuloma was described and routine examination was advised to the patient

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Diffuse midline gliomas with the histone 3-lysine-27-methionine (H3K27M) mutation should be considered in the differential diagnosis of recurrent hemiparesis and headache in patients with midline brainstem lesions, even with the absence of contrast-enhancement. Early diagnosis is essential for prognostication and engagement in trials evaluating novel therapeutics such as ONC-201.

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Buschke-Lowenstein tumor or giant condyloma acuminata is a rare disorder of the external genitalia, belonging to the group of verrucous carcinomas, and usually affects immunocompromised men. Human Papillomavirus (HPV) 6 and 11 are potentially involved in the pathophysiology. A detailed questioning, a rigorous clinical examination and complementary imaging are important to establish an accurate lesion assessment and an adapted management. Wide surgical excision is the treatment of choice.

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An eight-year-old boy with Kabuki Syndrome (KS) and an enlarging CNS mass is presented. The ‘tumor’ was discovered incidentally during MR imaging for a behavioral disorder and was located within the left globus pallidus. Retrospective review of previous MRIs showed no abnormality in the basal ganglia seven years earlier but a small region (a few pixels) of increased in T2 signal intensity three years earlier.

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Distant metastases from follicular thyroid carcinoma are not uncommon, but bone localization in the cranial vault is extremely rare. Although these metastases have a poor prognosis, early diagnosis and appropriate treatment can improve quality of life. We report a case of follicular thyroid carcinoma revealed by a metastasis of the cranial vault initially diagnosed as meningioma.

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Multiple primary parotid gland tumors are rare, accounting for 1.7-5% of all parotid neoplasms, and the occurrence of bilateral parotid gland tumors is even lower (1.3-3.5%). These tumors can be synchronous or metachronous and the most common histologic type of bilateral parotid gland tumors is Warthin tumor (79.2-90%). Combined benign and malignant lesions and bilateral neoplasms of different histologic types are even less frequently found.

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40-day male infant has admitted to the hospital by family. He has a complaint including lack of suction, vomiting, decreased of movements and continuous sleep about a week of ongoing. Brain computed tomography recognized a mass (with hyperdense hemorrhage) in the posterior fossa and right cerebellar hemisphere.

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Recombinant tumor necrosis factor -thymosin alpha 1 (TNF-T) has been used in Russian oncological practice for a number of years.

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Inflammatory pseudotumors are lesions characterized by inflammatory cell infiltration and fibrosis. Central nervous system (CNS) inflammatory pseudotumors are much rarer, and generally manifest in the sellar and parasellar regions. We report a patient with an inflammatory pseudotumor in the temporal and occipital lobes treated in our department in 2017, and present a literature review. We discuss the etiology, imaging, pathology, and treatment of intracranial inflammatory pseudotumors.

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Para-testicular rhabdomyosarcoma (RPT) is a rare tumor of children and adolescents. The diagnosis is made by the anatomopathological study. The treatment must be multimodal and involves surgery, chemotherapy and radiotherapy. We report the case of a 19-year-old adolescent in our department for an embryonic-type para-testicular rhabdomyosarcoma. Our aim is to expose a rare and unknown case that may be life-threatening. We would like to emphasize on the fact that paratesticular rhabdomyosarcoma need to be brought up in front of a tissular process expanding in the scrotum with normal testicules.

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Granular cell tumor, also known as Abrikossoff tumor, is a rare lesion that arises from the nervous system. Most of these tumors are benign and only 1-2% are malignant. Although they can be found in any part of the human body, 45-65% appears in the head and neck region, mainly in the oral cavity. Here, we report 2 cases of granular cell tumor of the tongue, diagnosed by excisional biopsy. Until the present moment, both patients remain with no recurrence.

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