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Articles Related to USP

Infective Endocarditis at Tricuspid Valve in CHD: What are its Characteristics? What is the Pathophysiology?

Infective endocarditis (IE) is a serious infectious disease that carries a high mortality rate. We report the case of 74-year-old female who is a chronic hemodialysis patient, and was presented with tricuspid valve endocarditis (TVIE) with central venous catheter, due to an Enterobacter Cloacae, which is a non-HACEK Gram-negative bacilli (GNB) and has been reported to be an extremely rare pathogen of IE. The patient was treated with imipenem and teicoplanin for a four-week period, with negative Blood culture and normal C reactive protein (CRP) levels at the end. The aim of our study is to understand the pathophysiology of the IE in chronic renal failure (CRF) especially at the tricuspid valve (TV), and to determine the clinical, biological characteristics and therapeutic modalities.
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Suspected Allergic Reaction in Bottlenose Dolphins (Tursiops truncatus)

Over the course of several years, three members of a Bottlenose dolphin (Tursiops truncatus) group showed periodical bouts of pruritus and dermatological lesions. The affected animals were a 25-year-old cow and her 5 and 7-year-old offspring, all housed in a mixed indoor/outdoor facility. The signs were first noted in 2005 and escalated over time until 2012, when a final diagnosis of the problem was attempted. Diagnostic tests included blood analysis and skin biopsies, swab microbiological cultures from the wheals, intradermal tests and response to treatment with corticosteroids. Clinical picture and histopathological findings, as well as response to methylprednisolone, were considered compatible with an allergic dermatitis.
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Clavicle Fractures: Allman and Neer Classification

Clavicle fractures are common injuries in young adults and children, and diagnosis can often be made based on history and physical exam. Treatment decisions vary according to the fracture’s location and multiple classification schemes have been devised to describe fracture patterns. The Allman model is the most widely used, which Dr. Neer subsequently revised to further delineate distal clavicle patterns. This article will illustrate the anatomy of the clavicle, its attachments and clinically relevant injury patterns. It is imperative to accurately classify these injuries as clinical outcomes and management options vary according to their morphology.
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Death Penalty in China after the Ninth Amendment: Legislatively Abolishing and Judicially Limiting

This paper supplies some possible approaches to death penalty reform in China based on analyzing the reforms attempted by the Ninth Amendment. There now are 46 crimes punishable by death, and this penalty still plays a significant role in the criminal punishment structure.
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New Approach for Examination of Pattern Evidences: Cases study

Improvement in technology has changed the techniques and pattern of examination of the physical evidences. The technology based gazettes like PDA, Computer and digital camera has improved the process of examination and speed of file-work while examination.
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Addressing the Risk of Product Fraud: A Case Study of the Nigerian Combating Counterfeiting and Sub-Standard Medicines Initiatives

Combating counterfeit medicines requires a new and unique crime scene investigation and forensic science approach. The “crime scene” is both at the production of the counterfeit product anywhere in the world and simultaneously at the packaged product in a consumer’s hand.
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Orally Disintegrating Tablets: A Short Review

This article summarizes the advantages of orally disintegrating tablets (ODTs) as well as critical issues during evaluation of ODTs such as bioequivalence and challenges and limitations of ODTs and finally present and the future of ODTs. ODTs have received everincreasing demand and the field has become a rapidly growing area in the pharmaceutical industry.
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Evaluation of Luffa Aegyptica Mill Powder: A Novel Superdisintegrant in Delayed Release Tablets

The current research in the field of drug delivery by which pulsatile release can be achieved has been intensified. The objective of the present study was to evaluate Luffa aegyptica mill powder as a novel superdisintegrant in the development of pulsatile drug delivery system (PDDS).
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Formulation and Evalution of Oral Reconstitutable Suspension of Cefpodoxime Proxetil

Cefpodoxime proxetil (CFPD PRXL) is broad spectrum, third generation cephalosporin; antibiotic. It is extremely bitter taste resulting in poor patient compliance. The aim of the present work was to prepare drug resin complex (DRC) using ion exchange resin (Kyron T-114) for taste masking and formulate oral reconstitutable suspension of DRC.
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Croscarmellose Sodium Efficiency in the Development of a Generic Capsule Formulation of Piroxicam, Comparable Dissolution Profile to the Innovator Product, Feldene

The objective of this study was to evaluate the encapsulation performance of Croscarmellose sodium, a superdisintegrant in a low-dose, poor-solubility drug formulation and the in-vitro dissolution performance of the Piroxicam capsules. Preparation, characterization and evaluation of the effects of the different concentrations of carmellose sodium and the amount of dried starch on in-vitro dissolution of Piroxicam capsules. Piroxicam was chosen for its very low solubility in biological fluids, which result in poor systemic bioavailability after oral administration. Piroxicam can be categorized as Class II drugs according to the Biopharmaceutics Classification System.
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Wet Granulation to Overcome Liquisolid Technique Issues of Poor Flowability and Compactibility: A Study to Enhance Glibenclamide Dissolution

The aim of this study is to apply wet granulation on liquisolid powders to overcome issues of poor powder flowability and compressibility especially with using high viscosity liquid vehicles. Different liquisolid formulations were made using three excipients where the effect of each excipient used in the dissolution of the model hydrophobic drug (Glibenclamide) was evaluated. The Glibenclamide tablets were formulated using PEG 400, Synperonic PE/L44 and Cremophor ELP, at a 10 %w/w in liquid vehicle drug concentration. The carrier (Avicel®PH102) was used followed by colloidal silicon dioxide (coating material) that converted the wet mixture into dry powder. Potato starch, 5%w/w, as a disintegrant was mixed with the mixture manually for 10 minutes and was finalized by adding 0.75% of magnesium stearate as a lubricant.
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Complete Green Synthesis of Gold Nanoparticles using Laser Ablation in Deionized Water Containing Chitosan and Starch

In this paper we report our results on the green synthesis of nontoxic, stable, and small size gold nanoparticle suspensions. We used the single and two-beam laser to ablate a gold target submerged in deionized water containing chitosan or starch as the stabilizing agent. Since both chitosan and starch are biodegradable and biocompatible, use of these natural polymers for gold nanoparticle protection and stabilization does not introduce any environmental toxicity or biological hazards.
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The Ni(II) Complex of 2-Hydroxy-Pyridine-N-Oxide 2-Isothionate: Synthesis, Characterization, Biological Studies, and X-ray Crystal Structures using (1) Cu Kα Data and (2) Synchrotron Data

C12H20N6NiO6S2 or NiL2(SCN)2](NH4)2.2H2O, where L is 2-hydroxy-pyridine-N-oxide, has been prepared and characterized using elemental analyses, IR, UV and visible spectrometry, magnetic moment measurements, thermal analyses and single crystal X-ray analyis. The results indicate that the complex reacts as a bidentate ligand and is bound to the metal ion via the two oxygen atoms of the ligand (HL).
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Topical Delivery System for Phytochemicals: Capsaicin and Capsicum Tincture

Capsaicin, an active ingredient of Capsicum fruit, is currently undergoing “revival” in the clinical management of pain. However, the choice of its formulation is rather limited to the use of “old-fashioned” tinctures and recently the patches. In an attempt to improve the therapeutic outcome and develop its skin-friendly formulation, we prepared the vesicle-based drug delivery system with capsaicin.
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Editorial Board Members Related to USP

SHAUKAT ALI

Technical Support Manager
BASF Corporation
Pharma Solutions
United States

Marion A Hofmann Bowman

Assistant Professor
Department of Medicine
Section of Cardiology
University of Chicago
United States

ALAA EL-DEEN BAKRY YASSIN

Associate Professor
Department of Pharmaceutical Sciences
King Saud bin Abdulaziz University for Health Sciences
Saudi Arabia

Mohsen Meydani

Professor
Friedman School of Nutrition Science and Policy
Tufts University
United States
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