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Long-Term Outcome of Juvenile Idiopathic Arthritis in Early Adulthood: Clinical Experience from a Saudi Tertiary Hospital

To report the long-term outcome including disease activity, damage and social status, quality of life at the last follow-up visit in a Saudi cohort of adults with juvenile idiopathic arthritis (JIA), and to determine the predictive factors.
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Efficacy of Chitosan as Vaccine Adjuvant Against Paracoccidioidomycosis in Mice

Paracoccidioidomycosis (PCM) is a systemic disease caused by thermo- dimorphic fungi of Paracoccidioides genus that is endemic in several Latin American countries. The treatment for this disease can be performed with different drugs. In general, it is a long duration treatment that aims the control of the clinical manifestations. Even after treatment, the patient usually shows relapse and incapacitating sequelae, such as fibrosis and pulmonary emphysema.
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Sequence Variant in the TRIM39-RPP21 Gene Readthrough is Shared Across a Cohort of Arabian Foals Diagnosed with Juvenile Idiopathic Epilepsy

Juvenile idiopathic epilepsy (JIE) is a self-limiting neurological disorder with a suspected genetic predisposition affecting young Arabian foals of the Egyptian lineage. The condition is characterized by tonic-clonic seizures with intermittent post-ictal blindness, in which most incidents are sporadic and unrecognized. This study aimed to identify genetic components shared across a local cohort of Arabian foals diagnosed with JIE via a combined whole genome and targeted resequencing approach: Initial whole genome comparisons between a small cohort of nine diagnosed foals (cases) and 27 controls from other horse breeds identified variants uniquely shared amongst the case cohort.
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The Case of Fetal Maceration in Two Different Bitches

Prenatal development consists of three stages in dogs. These stages are called preimplantation, embryonic and fetal period respectively. Embryonic or fetal losses may occur as a result of any causes that damage embryo or fetus during prenatal development period. These losses are called resorption, abortion, mummification and maceration according to the stage of pregnancy. Fetal maceration is often observed in cattle, but also can occur in other domestic animals. The incidence is quite low in bitches. The materials of this case were two bitches in different breeds that are Pointer and Golden retriever. They were brought to Clinics of Obstetrics and Gynecology by their owners with the complaints of growth in their abdomen, increase in weight and decrease in movements at different times. Firstly, detailed anamnesis was taken from their owners. As the mating status of both bitches is unknown, the probabilities of pregnancy and pregnancy pathologies have been neglected in the clinics previously referred to with the same complaints and both bitches were diagnosed with obesity by considering breed predisposition. In this context, it was learned that there was no treatment except for the suggestion of on low energy content foods and exercises however no healthy improvements were observed in both bitches. Gynecological, ultrasonography and radiographic examinations, whole blood and serum biochemistry analysis were performed on both bitches after anamnesis was taken. When the findings of the analysis and examination were evaluated, it was concluded that the fetuses were autolyzed in the uterus without being aborted. It was concluded to perform ovariohysterectomy operation on both dogs for treatment. When the removed uterus tissues were examined, it was seen that both bitches had fetal maceration.
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Late Cerebellar Vermis Metastasis of Breast Cancer Presenting as Pseudo-Benign Paroxysmal Positional Vertigo

Benign paroxysmal positional vertigo (BPPV) is a common peripheral vestibular disease; however intracranial lesions can mimic it. Intractable, not self-limiting paroxysmal positional vertigo sustained by intracranial tumors is called malignant paroxysmal positional vertigo (MPPV) while, when radiological imaging shows vascular cerebellar vermis lesions and there are atypical findings on the Dix-Hallpike maneuver, we speak about pseudo-benign paroxysmal type (pseudo-BPPV).
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Liquid Biopsy in Advanced Gastric Malignancy and Molecular Targeted Therapy; a Case Report and Update Pertaining Anti HER2-Neu Therapy

Human epidermal growth factor receptor 2 (HER2) is responsible for the pathogenesis and poor outcomes of several types of cancers, including advanced gastric and gastroesophageal junction cancer. Molecular-targeted drugs on the other hand, such as trastuzumab, prolong overall survival and progression-free survival in HER2-positive gastric cancer. The purpose of the case report is to evaluate the impact of delivering trastuzumab in advanced gastric cancer with concomitant HER2 mutation and amplification.
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Palatal Rugae Patterns as an Adjuvant to Gender Determination in Forensic Identification Procedures in a Paediatric Population

Identification of an individual who is either living or dead is based on the assumption that all individuals are unique. Whenever an unidentified corpse is found, the individual is classified into characteristic groups and finally the various possibilities are narrowed down.
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Inguinal Lymph Node Squamous Cell Carcinoma of Unknown Primary Site: A Case Report

Carcinoma of unknown primary site (CUP) is a heterogeneous group of malignancies associated with dismal prognosis. Although majority of the patients present with disseminated disease, some of them do present with disease limited to the lymph nodes.
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Responses and Survival under Pegylated Interferon α2a Treatment for Patients with Post-MPN Acute Myeloid Leukemia and Acute Panmyelosis with Myelofibrosis

We report here for the first time the efficacy of pegylated interferon α2a (Peg-Ifn) as a therapy for patients with myelofibrosis and high blast counts. We treated four patients who were in an accelerated phase of myeloproliferative neoplasms or acute panmyelosis with myelofibrosis using only this drug.
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Improvements to In Vitro Culture Media for Use in Bovine IVF

In assisted reproduction of cattle the design and preparation of in vitro culture media has been instrumental in supporting the development of bovine oocytes and embryos. In vitro production (IVP) involves three main sequential steps: oocyte aspiration and in vitro maturation (IVM); in vitro fertilization (IVF); and in vitro culture (IVC) of early pre-implantation embryos.
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Effect of Neoadjuvant Chemoradiotherapy on Pathologic Stage and Survival in Patients with Locally Advanced Esophageal Cancer

The treatment of resectable stages of esophageal cancer often involves pre-operative concurrent chemoradiotherapy. This study aims to evaluate the effect of cisplatin/5-fluorouracil (5-FU)-based neoadjuvant chemoradiotherapy on pathologic stage and survival in patients with locally advanced esophageal cancer.
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Gastroesophageal Cancer: Prognostic Factors and Treatment Results

The study presents the remote results of surgical treatment of 329 patients with cancer of gastroesophageal localization. Three 3-year survival rate is 37.1%, the 5-year survival rate is 26.2%. Prognosis after the surgery depends primarily on the extent of the tumour spread.
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Age Adjusted Charlson Comorbidity Index: Predictor of 90-Day Mortality after Radical Cystectomy

To evaluate the impact of age adjusted Charlson’s comorbidity index (ACCI) in predicting 90-day mortality in patients undergoing radical cystectomy for Muscle Invasive Bladder Cancer (MIBC) in a low volume center.
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IL-8 Regulates Epithelial-Mesenchymal Transition through pERK1/2 in AGS Cells

The aim of this project was to evaluate the influence of inflammatory cytokines IL-1β and IL-8 on gastric epithelial-mesenchymal transition in gastric epithelial cells.
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UVC-Shielding by Nano-TiO2/PMMA Composite: A Chemical Approach

A translucent UV protecting poly (methyl methacrylate) (PMMA)/TiO2 nanocomposite has been fabricated using anatase TiO2 nanoparticles by solution method. The myristic acid capped titania nanoparticles were synthesized via a simple sol-gel method, involving hydrolysis of titanium tetra isopropoxide (TTIP).
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Editorial Board Members Related to UV

Dr. Amarnath Mishra

Assistant Professor
Amity Institute of Forensic Sciences
Amity University
India

Andrew Percy

Genome BC Proteomics Centre
University of Victoria
Canada

Hani Mansour

Associate Professor
Department of Water Relations & Field /irrigation
National Research Center
Egypt

Rajajeyakumar Manivel

Assistant Professor
Department of Physiology
Chennai Medical College Hospital & Research Centre (SRM Group)
Irungalur, Trichy, Tamilnadu
India

Mayra Anton Dib Saleh

Researcher
Animal Production Department
São Paulo State University
Brazil

Weibin Shi

Associate Professor
Radiology and Biochemistry & Molecular Genetics
University of Virginia
United States

Curd Bollen

Professor
Department of periodontology
Parimplant Research Group
Netherlands

Juan Jose Alava

Research Associate
Faculty of Science
The University of British Columbia
Canada

Ren-Ke Li

Professor
Laboratory Medicine and Pathobiology
University of Toronto
Canada

Jiang He

Associate Professor
Department of Radiology and Medical Imaging
University of Virginia
United States
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