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Articles Related to VU

Reversed-Phase High Performance Liquid Chromatography Procedure for the Determination of Isavuconazole in Human Plasma

Introduction: Isavuconazole is an antifungal drug used for treating patients with invasive fungal infections. Efficacy and safety of isavuconazole is monitored by measuring plasma isavuconazole concentration using LCMS which is a non-affordable method. We used the HPLC system with a UV detector to measure plasma Isavuconazole concentration. Objective: Improved Reversed-phase high performance liquid chromatography procedure with UV detection is described which is cost effective, simple, precise and easily processed for the measurement of Isavuconazole, a drug used to treat the patients with invasive fungal infections, in blood plasma. Method: The method involves protein precipitation, addition of ammonium dihydrogen phosphate and chromatographic separation on a Hypurity C18 Column using an isocratic mobile phase of acetonitrile and ammonium acetate buffer (pH 8.0, 10 mM) (55:45, v/v). The UV detection was performed at 285 nm. The method provides rapid resolution of Isavuconazole in a 50 uL injection. Result: Lower limit of Quantification (LLOQ) is 0.25 μg/ml in a 50 uL injection volume for Isavuconazole with a recovery consistently > 100 %. The assay is validated over linear range of 0.25 to 10 μg/ml. The intra-assay precision is < 3.53 % and inter-assay is <6.38% relative standard deviation of Isavuconazole. The method demonstrated clean separation, clinically acceptable detection limit and a linear range upto 25 ug/mL. Conclusion: The assay demonstrated applicability in quantifying the drug level and monitoring the therapeutic dose for maintaining effective biological level to have better response in fungal infected patients. The method is cheaper as compared to LC-MS/MS and Tandem Mass spectrometry and the results are reportable on the same day of blood collection.
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The Present Scenario of Lathyrisum Regarding Public Health in 2021

Backgrounds: Neurolathyrism is a disease, which is linked with the consumption of Lathyrus sativus ( L. sativusi) pulse that contain the neurotoxin-beta-N-oxalyl-L-alpha-beta-diamino propionic acid (beta-ODAP). Patients with Lathyrisum suffer with gradual enhancement in spasticity and bony changes, which are responsible for appearing the crippling condition throughout life. Objective: The present study has been done as to establish the present situation of L. sativusi consumption and Lathyrisum. Materials and Methods:We performed the survey in the village of Mohammadabad Block of Gazipur district in Eastern Uttar Pradesh (a state with maximum population in India) which have population of million, and L. sativusi is the main pulse of the year, which sustains the economy of these populations. Results:Out of 21,234 subjects L. sativusi eating population for more than 10 years, none had Lathyrisum. On contrary, to popular belief, this population enjoys various dishes made by L. sativusi pulse which in popular are local delicacy. Conclusions:There is no evidence of L. sativusi causing Lathyrisum in 2021. On contrary, L. sativusi pulses have become an inheriting part of the food habits in these populations.
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Genomic Asymmetry for Morphology in Allopolyploids within and Out of Brassica

The genomic asymmetry in the nonrandom retention and expression of controlling genes for some traits from one parental diploid is obvious in some natural and synthetic allopolyploids, and has the evolutionary implications. Here we review the genomic asymmetry for the morphological performance in three cultivated Brassica allotetraploids and some intergeneric allopolyploids within Brassicaceae species. For the phenotypic biases of Brassica allotetraploids, Brassica oleracea (genomes CC) is dominant over B. nigra (BB) and B. rapa (AA) in B. carinata (CCBB) and B. napus (CCAA), respectively, and B. nigra is dominant over B. rapa in B. juncea (BBAA), showing the C>B>A dominance hierarchy.
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Buschke-Lowenstein Tumor of the Vulva: A Case Report

Buschke-Lowenstein tumor or giant condyloma acuminata is a rare disorder of the external genitalia, belonging to the group of verrucous carcinomas, and usually affects immunocompromised men. Human Papillomavirus (HPV) 6 and 11 are potentially involved in the pathophysiology. A detailed questioning, a rigorous clinical examination and complementary imaging are important to establish an accurate lesion assessment and an adapted management. Wide surgical excision is the treatment of choice.
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Tricuspid Valvulectomy in Drug Addicts with Native Valve Endocarditis: A Case Series

From Jan –2004 to Dec-2004, five patients were referred to the surgical department with a diagnosis of endocarditis refractory to medical therapy. Patients were all male, age ranging 16 years to 28 years with a mean of 22 years. All of the five patients had native valve endocarditis of the tricuspid valve with a history of drug addiction in common. Their presentations included, sepsis, failure and recurrent pulmonary embolism. Three of them had bacterial, while two had fungal infection which was proven after blood cultures. After resuscitation, stabilization and preoperative workup, tricuspid valvectomy was performed on these patients because of the destructive and irreparable nature of the native valve. Fortunately, all had uneventful recovery after surgery. Pre-operatively these patients were treated with antibiotics and antifungals, and continued thereafter for almost 4 to 6 weeks in the post-operative period. Postoperatively there was significant tricuspid regurgitation in a subset of patients who had a follow-up. The Left Ventricular (LV) function remained normal to moderate with a moderate pulmonary artery pressure. These patients were discharged on antibiotics and anti-failure medications as per the GDMT.
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HIV Screening Scenarios and Targets to Achieve 90% Sero-Status Knowledge Over 2021-2025 in Morocco – Pioneer Use Case of the Goals HIV Testing Strategies Model in a Concentrated Epidemic

Morocco applied the Goals testing model, projecting alternative testing scale-up scenarios, varying coverage targets for 13 adult populations. The model was calibrated using program service delivery, spending and surveillance data (2015-2019), integrated bio-behavioural surveys, and national HIV estimates. It projects annual diagnoses by target group from undiagnosed prevalence and testing coverage, allowing for HIV-infected people self-selecting for testing, retesting and transitions between groups. Scenarios were evaluated for knowledge status improvement and cost, focusing on 2023-2025.
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In vitro Digestibility of Indian Bamboo (Bambusa vulgaris) Leaves Associated with Stylosanthes guianensisin Ruminants

The study of the in vitrodigestibility of Indian bamboo (Bambusa vulgaris) leaves associated with Stylosanthes guianensisin ruminants was conducted in April 2019 in the Animal Production and Nutrition Research Unit of the University of Dschang. A bovine ruminal fluid, a source of energy (B. vulgaris) and a nitrogen source (S.guianensis) with or without polyethylene glycol (PEG) were used. A sample of rations based on B. vulgarisassociated with 0; 20 and 30% of S.guianensis, with or without PEG was removed, dried and milled to determine the chemical composition and evaluation of in vitrodigestibility. Results of this study showed that the addition of legume increased the total nitrogen content (MAT) (12.87, 13.03 and 13.56% DM) when the B. vulgariswas associated with 0; 20 and 30% S.guianensis.
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Greater Trochanter Avulsion Associated with Posterior Hip Dislocation

Hip dislocation occurs when axial loading force is transmitted through intact femoral shaft to the hip joint leading to a posterior dislocation of the femoral head with or without posterior acetabular fracture. However dislocation of the hip with associated fracture of the trochanter, neck or shaft of femur is uncommon in literature. We present the case of a 56 year old patient who fell from a height. Clinical and imaging [radiography, CT] examination revealed a comminuted greater trochanteric fracture associated with ipsilateral posterior hip dislocation.
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Developing Sigmoid Volvulus after Medical Disimpaction of a Patient with Stool Impaction: A Case Report

Stool impaction is an ailment resulted from chronic constipation which commonly found in the elderly population. It causes wide range of potential complications if not promptly diagnosed and treated. These complications doubled when elder people experience other comorbidities. A case of an 80 years old lady with advanced dementia, bedridden and non-communicating is presented for clinical study. This patient who was presented with abdominal distention and changes in her mental status was found to have stool impaction based on the clinical and radiological test conducted to her.
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A Novel Neuroprotective and Antioxidative Efficacy of a Unique Combination of Standardized Huperzia serrata, Convolvulus pluricaulis and Celastrus paniculatus Extracts

Physical and environmental stress in conjunction with hectic lifestyle and unhealthy food habits are the major cause of diverse neurodegenerative disorders. Oxidative neuronal injury and acetylcholine deficiency have a major impact on learning and memory retention. Most of the treatment strategies are based on the improvement of cholinergic function in the brain and one of the emerging therapeutic targets is to enhance the acetylcholine level in the brain. Standardized botanical extracts including Huperzia serrata (1% Huperzine A, CogniUp), Convolvulus pluricaulis (SP) and Celastrus paniculatus (JY) have been demonstrated to attenuate brain function by serving as a natural acetylcholinesterase (AChE) inhibitor.
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Proximal Avulsion of Ulnar Collateral Ligament of the Thumb

Injuries of the Ulnar collateral ligament (UCL) of the metacarpophalangeal (MCP) joint of the thumb are relatively common and well described in the literature. Stener lesion refers to the displacement of the avulsed distal end of the UCL, moving to lie over the adductor aponeurosis making the chances of spontaneous healing impossible [1].
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Epidemiological Profile of Congenital Cardiopathy Neonatal Revelation in Tehran

Congenital heart disease is the most common congenital disorder in newborns represents a major cause of perinatal death. The prevalence of these malformations is still unrecognized in Tunisia because of the lack of a national register. The aim of this study was describe the epidemiological and clinical aspects of the heart diseases with neonatal diagnosis in Tunisia.
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Positive Efficiency of Combine Immunotherapy in Immunocompromised Girls with Recurrent Nonspecific Chronic Vulvovaginitis

Nonspecific chronic vulvovaginites (NCVV) are a frequent clinical sign of immune deficiency, especially in young girls. The established problems with the functioning of various parts of the immune system (IS) in this pathology dictate the need to include immunomodulatory therapy into the complex. The developed program of combined immunotherapy for immunocompromised girls allows reducing the severity and duration of exacerbation of NCVV, their frequency against the background of a significant reduction in ARVI incidence. Positive clinical effects were observed with underlying restoration in IS functioning. A protective effect was obtained (observation in a catamnesis for 1 year): the duration of a clinically safe period increased from 6 to 11-11.5 months per year.
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Use of Electroconvulsive Therapy (ECT) in Hysterical Catatonia: Case Reports of Two Women, One Young and One Elderly

A 62-years-old female patient with a diagnosis of conversion disorder and somatization disorder and a 20-years-old female patient with a diagnosis of conversion disorder were treated on electroconvulsive therapy. Electroconvulsive therapy was performed in 8 sessions with anaesthesia. 62-years-old patient began to recover after the sixth session of electroconvulsive therapy once every two days. Complete remission in catatonic symptoms also sustained during follow-up. The catatonic symptoms of the 20-years-old patient were completely terminated after the second session of the ECT once every two days. The treatments were completed in 8 sessions.
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Egg White-Milk Mixture as a Novel Biological Storage Media for Avulsed teeth Periodontal Ligament Cells: An In-Vitro Study

Purpose: This study aimed to evaluate egg white-milk mixture as a novel storage medium for avulsed teeth compared to Hank’s Balanced Salt Solution (HBSS) media.Materials and media: Ninety incisors teeth of 23 New Zealand rabbits were atraumatically extracted and divided into 6 equal groups. Group 1, 2 & 3 were immediately stored in HBSS media for 1, 4 & 6h respectively, while group 4, 5 & 6 were stored in egg white-milk for 1, 4 & 6h respectively. The teeth were prepared for histological investigation and digital counting of periodontal ligament (PDL) cells using trypan blue exclusion technique.
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Editorial Board Members Related to VU

D.Sivaraman

Scientist-C
Centre for Laboratory Animal Technology and Research
Sathyabama Institute of Science and Technology, Tamil Nadu
India

IRENE HATSU

Assistant Professor
Department of Human Science
The Ohio State University
United States

Vural Fidan

Associate Professor
Deputy Director of ENT Department
Emre Government Hospital
Turkey

Saber Mohamed Abd-Allah

Associate Professor
Department of Theriogenology
Faculty of Veterinary Medicine
Egypt

Mohd Shahbaaz khan

Assistant Consultant Cardiac Surgeon
King Salman Heart Centre
King Fahad Medical City
Riyadh, kindom of Saudi Arabia
Saudi Arabia

Vural Fidan

Vural Fidan, M.D. Department of Otorhinolaryngology
Hacettepe University
Yunus Emre Government Hospital
Turkey

Isabelle Perroteau

Professor
Department of Clinical and Biological Sciences
University of Turin
Italy

J Vernon Odom

Professor
Department of Ophthalmology
West Virginia University
United States

RAMPRASAD SRIPADA

Clinical Associate Professor
Department of Anesthesia
University of Iowa Hospitals and Clinics
United States

Douglas Wilson

Professor
School Medicine Pharmacy and Health
Durham University
UK
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