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Pharmacokinetics Bridging Study of a 400 Mg Extended Release Formulation of the Novel Fumaric Acid Ester PPC-06 (Tepilamide Fumarate) in Healthy Male Volunteers

Tepilamide fumarate (PPC-06) is a new, patented prodrug of monomethyl fumarate (MMF), belonging to the fumaric acid esters (FAEs) class of drugs. The efficacy and safety of a 400 mg PPC-06 dose administered twice daily, achieved thus far through concomitant intake of two tablets of 200 mg, was demonstrated previously in two Phase 2 clinical trials on patients with moderate to severe chronic plaque-type psoriasis.
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Influence of Guanidinoacetic Acid Supplementation of Fish Diets with Different Levels of Energy Content on Growth Performance and Serum Metabolites

This research was performed to explore the impacts of guanidinoacetic acid (GAA) supplementation of fish diets with variable energy contents on the growth performance and blood serum parameters of Nile tilapia fish. Nile tilapia Juveniles with an average weight of 20 g were cultured in glass aquaria and fed four formulated pelleted diets for 60 days. Our experiment was divided into four experimental groups: the first group (G1) was fed a basic control diet without any GAA supplementation. The other experimental groups, G2, G3 and G4, were fed diets with different levels of energy (25, 50 and 75 kcal/kg less than in the control, respectively) and supplemented with 0.06% GAA.
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Characterization of the Consciousness Energy Healing Treated Essential Amino Acid: L-Tryptophan

L-tryptophan is an amino acid which helps in the formation of proteins and certain brain-signaling chemicals, etc.
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Transient Bacteria Removal by Concentrated Sulfuric Acid for Cell Pollution

We found and recommended a method for rapid and effective sterilization by using concentrated sulfuric acid in cell culture.
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Pharmacokinetics of a 1,000 mg Disintegrating Aspirin Tablet Formulation

Migraine is a global disorder and considerably affecting people`s quality of life. Treatments include nonsteroidal anti-inflammatory drugs-containing medicinal products among whom acetylsalicylic acid-containing Aspirin® has been proven effectively to relief migraine headache. Early treatment is recommended for patients with migraine attacks.
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Comparison of Chemical Composition of Pomegranate (Punica Granatum L.) and Grape (Vitis Vinifera L.) Seed Oils Obtained By Extraction

In this study, it was aimed to assess pomegranate (punica granatum L.) and grape (vitis vinifera L.) seed oil by comparing them physically and chemically. The fat output of the pomegranate (punica granatum L.) and grape (vitis vinifera L.) seeds was determined by the standard method of soxhlet extraction.
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Biological Availability of Phosphorus in Raw and Acidulated Sinda and Chilembwe Rock Phosphates in Broiler Chickens

A 14 day broiler chickens feeding trial was conducted to determine bio-availability and relative biological values (RBV) of phosphorus in raw and acidulated local rock phosphates (RPs) as potential replacements for imported and more expensive di-calcium phosphate (DCP). Treatments included Raw, Sulphuric acid and Phosphoric acid acidulated Sinda and Chilembwe RPs. Bio-availability was assessed based on feed intake, body weight gains, feed conversion ratios, phosphorus retention and mineralization of tibia bones and blood serum. RBVs were calculated on the same parameters using DCP as a reference standard. Phosphorus contents in local RPs were significantly (P ≥ 0.05) lower than in DCP, but acidulating RPs with Phosphoric acid significantly increased phosphorus, but reduced calcium contents. Other minerals were comparable with what was in DCP. Acidulating RPs significantly (P ≥ 0.05) increased body weight gains and feed conversion ratios, but not feed intake. Phosphorus retentions, weights and ash contents of tibia bones were significantly (P ≥ 0.05) lower in chickens fed diets based on raw than that of those fed diets based on acidulated RPs and DCP; an indication that acidulating the RPs improved phosphorus bio-availability in broiler chickens. There were however; no statistical differences (P ≥ 0.05) among treatments in calcium and phosphorus contents in both tibia bones and blood serum.
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Protective Ability of Vitamin E Against Acetylsalicylic Acid-Induced Glutathione Depletion, Acetylcholinesterase and (Na+ ,K+ )-ATPase Activities, and Erythrocyte Osmotic Fragility

Acetylsalicylic acid (ASA), a well-recognized non-steroidal anti-inflammatory drug (NSAID), is well known for the treatment of fever, pain alleviation and inflammatory conditions, especially for the prevention of cardiovascular complications and disorders. However, ASA has been reported to cause hepato- and gastro-toxicities.
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Xeroderma Pigmentosum Groups C and A in Algerian Patients with Deregulation of both Transcription and DNA Repair

Xeroderma Pigmentosum (XP) is a rare autosomal recessive disorder characterized by an extreme sensitivity to UV rays from sunlight, a high incidence of skin cancer and occasional neurological symptoms. XP, primarily defined as a DNA repair syndrome, has been found associated with defects in the Nucleotide Excision Repair (NER) pathway, and more recently by transcriptional deregulation. XP results from mutations in eight genes (XPA to XPG and XPV) coding for proteins involved in NER.
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Mitochondrial Production of Perhydroxyl Radical (HO2 • ) as Inducer of Aging and Age-Related Pathologies

All organisms age, in the search of the universal mechanisms of aging Barja analyzed results obtained with various species of mammals and birds and concluded that only two known factors correlate in the right sense (inversely) with animal longevity in vertebrates: the long life span is associated with (a) low rates of mitochondrial reactive oxygen species production, and (b) low degree of fatty acid polyunsaturation of cellular membranes including the mitochondrial ones [Barja (2014) Prog Mol Biol Transl Sci. 127:1-27].
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Comparison between Polyacid-Modified Composite Resin and Conventional Composite Resin used for Primary Molars Restoration

Ten recently extracted primary molars, were used in this study for the measurement of the shear bond strength. Occlusal enamel was ground, leaving a flat dentin surface, on which a cylindrical specimen of each of the two tested materials was applied and light-cured according to the manufacturer’s instructions. Specimens were then mounted in self-cure acrylic resin. Ten specimens were used for the measurement of the compressive strength. The specimens were prepared in a special-cylindrical mold, then light-cured according to the manufacturer’s instructions. The compressive and shear bond strength of each specimen was measured using a Universal Testing Machine.Ten specimens of each of the two resin materials were used to measure the abrasion resistance. The test was performed by means of a toothbrushing machine and abrasive dentifrice slurry. The specimens were weighed before and after the test. Weight loss of the specimens were calculated after the test and reported as percent weight loss. Regarding microleakage test, Class V cavities were prepared in the buccal surface of 36 exfoliated or extracted human primary molars.
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Methylmalonic Acidemia and Megaloblastic Anemia due to Congenital Intrinsic Factor Deficiency

Causes of vitamin B12 deficiency in children include decreased intake, abnormal absorption, and inborn errors of B12 transport and metabolism. Rare causes of abnormal cobalamin absorption include Imerslund-Grasbeck syndrome (IGS) and intrinsic factor deficiency (IFD). IGS and IFD are caused by defects in the genes CUBN, AMN, and GIF. We describe a 2 year old male who presented with severe megaloblastic anemia and methylmalonic acidemia. He was found to have a GIF heterozygous mutation c.79+1G>A associated with congenital gastric intrinsic factor deficiency and a novel variant c.960C>A in trans position.
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Jugular versus Mammary Vein Acid-Base Balance, Blood Gases, Hematobiochemical Profiles and Inflammation Biomarkers in Goats with Acute Mastitis

The objectives of this study was to investigate the acid-base balance, blood gases, hematobiochemical profiles and the inflammation biomarkers fibrinogen, serum amyloid A (SAA) and haptoglobin (Hp) in the mammary and jugular veins of goats with mastitis. Blood samples were collected from the jugular and mammary veins from 26 goats with mastitis and from 10 healthy lactating goats. In diseased goats, the affected quarter had a remarkable degree of swelling, hard and sore to touch; the milk was bloody. In the jugular vein of diseased goats, the values of PCO2, PO2, base excess (BE), HCO3 and TCO2 were significantly lower than in the jugular vein of controls.
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Cloning of Perilipin 2 Gene and Investigating its Expression Level in Porcine Longissimus Muscle

PLIN2 belongs to one member of PAT (Perilipin, Adipophilin and Tip47) family, which plays an important role in regulating lipid storage and could be regarded as a candidate gene for intramuscular fat deposition in pigs. This study tried to clone the coding domain sequence (CDS) of PLIN2 gene, compare the nucleotide acids and deduced amino acids sequence, physiological characteristics, structure and the expression level between Wujin (fatty breed) and Landrace (lean breed) pigs. The results showed that the mutation of nucleotide acids led to the mutation of deduced amino acids between two pig breeds.
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Isolation and Identification of Lactic Acid Bacteria from Algerian Durum Wheat (Triticum Durum) Natural Fermented in Underground Silos Matmora “El-Hammoum” and their Antimicrobial Activity Again Pathogenic Germs

In human nutrition, cereals constitute the basis of the food pyramid. In Algeria, storage of durum wheat (triticum durum) performs in underground silos matmour in some rural areas, these traditional methods rather simple conservation is an alternative for small producers; but starts to disappear because of settlement of the farming populations in the urban areas.
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Characteristic Human Scent Compounds Trapped on Natural and Synthetic Fabrics as analyzed by SPME-GC/MS

The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix), polyester, rayon and wool.
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Anodic Oxidation of Titanium in Sulphuric Acid and Phosphoric Acid Electrolytes

Anodisation of pure titanium has been carried out in sulphuric and in phosphoric acid solutions at potentials ranging from 50 to 150V. The SEM and AFM morphological analysis indicates that, within this potential range, oxidation in sulphuric acid solution produces better developed mesoporous oxide layers.
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Editorial Board Members Related to acid

Aladin M Boriek

Professor
Department of Medicine
Baylor College of Medicine
United States

Inbo Han

Associate professor
Department of Neurosurgery
CHA University
South Korea

Jagriti Narang Malhotra

Assistant Professor
Amity University
Noida
India

Rajat Subhra Das

Scientist
Omega Therapeutics
Cambridge
USA

Ramesh C. Gupta

Professor of Chemistry
School of Agricultural Sciences and Rural Development (SASRD)
Nagaland University
India

Mayra Anton Dib Saleh

Researcher
Animal Production Department
São Paulo State University
Brazil

Josep Bassaganya-Riera

Professor
Virginia Bioinformatics Institute
United States

Liqing Yu

Associate Professor
Departments of Animal and Avian Sciences
University of Maryland
United States

R. C. Gupta

Professor
Pro vice chancellor
Nagaland University
India

Ramesh Gupta

Professor of chemistry
Nagaland University
India
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