Articles Related to allergic rhinitis

Postnasal drip is one of the main causes of Upper Airway Cough Syndrome (UACS). Whether antibiotic targeted on rhinosinusitis accompanying UACS and chronic cough led to an improvement in a cough is controversy. Fifty-five schoolchildren, aged 4 to 14 years, were randomized into two groups: (1) Rhinosinusitis with allergic rhinitis, n = 20 (2) Rhinosinusitis alone, n = 35. The Spirometry, Forced Expiratory Volume in one second (FEV1), Forced Expiratory Flow (FEF) 25-75%, and Fractional Exhaled Nitric Oxide (FENO) were performed in all participants to rule out asthma or airway hypersensitivity. A pediatric allergist examined and recorded the clinical features, including stuffy nose, nasal discharge, postnasal drip, cough, facial, and halitosis. In addition, one senior radiologist examined and reported the results of water’s view and chest plain film for all schoolchildren. Both groups were given Amoxicillin/clavulanic acid twice a day for two weeks.

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The aim of this manuscript is to study cyclodextrins (CDs) as a potential excipient to suppress bitterness and enhance palatability of pediatric liquid preparations for Cetirizine, an extremely bitter drug. Natural α, β and γ CDs; and β CD derivatives such as hydroxyl propyl (HP), randomly methylated (RM) and sulfobutyl ether (SBE) β-CDs were screened in different molar ratios of 1:1, 1:2 and 1:3 for their inhibition of the extremely bitter taste of Cetirizine using the human gustatory sensation test.

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