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The study seeks to investigate the casual effect of the efficient energy use and GDP (economic growth) on fossil fuel consumption (Nonrenewable) for the sub Saharan Africa for the period 1980 to 2014. The study also seeks to investigate solutions to environmental issues. Zivot-Andrews unit root test with a structural break, Phillips and Perron unit root test with structural break revealed that the investigated variables become stationary at first-differences. The Gregory-Hansen cointegration test with a structural break shows efficient energy use, economic growth and energy consumption are co-integrated. The long-run estimates obtained from the VECM model indicate that in account of the changes in the structure of the economies, the environmental Kuznets curve does not exist due to validity of a U shaped curve. An increase in output growth (GDP) and efficient energy use positively affect environmental pollution. Based on the findings of this study, the study recommends investment in green technology as the economy growths.

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We aimed to determine whether the excision repair cross-complementation group 1 (ERCC1) expression predicts response to cisplatin-based chemotherapy in patients with small cell lung cancer (SCLC). This was a retrospective study, in which hospital files of 31 patients (29 males, 2 females; mean age, 62.26±7.71 years) were reviewed. All patients were treated with etoposide+cisplatin. The lung biopsy and mediastinal lymph node samples were applied anti-human monoclonal antibodies against ERCC1: immunohistochemical staining was considered positive if 25-100% of the cells showed nuclear staining, and negative if less than 25% of the cells showed negative or slight staining. Response to treatment was evaluated as regression (complete or partial response), progressive disease, or stable disease. Of the patients, 18 (58.1%) had limited-stage, and 13 (41.9%) had extensive-stage SCLC. Median follow-up duration was 15 months (range: 1-60 months). ERCC1 staining was positive in 9 of 31 patients (29.0%). In 12 patients (38.7%), tumor regression (complete or partial response) was obtained after chemotherapy. Tumor regression rate was higher in ERCC1 positive patients than those with negative ERCC1 expression (66.7% vs. 27.3%, p=0.036). In conclusion, high expression of ERCC1 was associated with higher response rate to cisplatin-based regimens in patients with SCLC.

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Squamous cell carcinoma of the external auditory canal may masquerade as an infective process causing late diagnosis. A delay in treatment as a result of missed diagnosis would carry a poor prognosis as the disease progresses to an advanced stage. We present a case of a man with history of chronic otorrhea, who developed left sided otalgia associated with hearing loss. otoscopic examination shows a mass in her left ear and pus discharge which was initially treated as an infection. The biopsy of the mass was proven to be squamous cell carcinoma. High index of suspicion is necessary when encountering patients presenting with a mass in the ear canal with prior history of chronic otorrhea or cholesteatoma. Proper tissue biopsy is crucial. Early diagnosis is required for better prognosis for the patient.

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One of the overarching goals of Nigeria agriculture development programs and policies is increasing agricultural productivity for accelerated economic growth. Despite the various policies measures to increase crop production, domestic rice production has not been increased enough to meet the rising population of the country “Nigeria”.

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Sanfilippo syndrome, a type of mucopolysaccharidosis (MPS), is an autosomal recessive lysosomal storage disease. The disorder is characterized by bone abnormalities (i.e. abnormally long arms and legs when compared with the trunk length), as well as abnormal bone shapes and skin thickening.In general, patients with Sanfilippo syndrome have sharp and coarse facial features, thickening of the lips and enlargement of the mouth and tongue. Hypoplasia of hard dental tissue is also present. The parents of a 5-year-old female patient were referred to Konya Oral and Dental Health Hospital because of tooth pain. A full dental examination could not be conducted because the patient was not cooperative. Thus, we decided to perform the patient’s treatment under general anaesthesia. As the patient had a history of difficult intubation and the planned dental procedures could be completed in a short time, under sedoanalgesia.

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In this paper, a mathematical five-dimensional dynamical system involving an SVEIR model of infectious disease transmission in a chemostat is proposed. A profound qualitative analysis is given. The analysis of the local and global stability of equilibrium points is carried out. It is proved that if R>1, then the disease-persistence (endemic) equilibrium is globally asymptotically stable. However, if 1≤R, then the disease-free equilibrium is globally asymptotically stable in R5.

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Congenital heart disease is the most common congenital disorder in newborns represents a major cause of perinatal death. The prevalence of these malformations is still unrecognized in Tunisia because of the lack of a national register. The aim of this study was describe the epidemiological and clinical aspects of the heart diseases with neonatal diagnosis in Tunisia.

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Overweight and obesity are emerging public health challenges in low-to-middle-income countries. Factors such as urbanization, physical inactivity, changing diets, and harmful consumption of alcohol contribute to this global growth in overweight and obesity, particularly in African countries. This study aimed to identify factors most predictive of overweight and obesity in adult women in Kenya.

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Planning for water resources development in a basin or over a region requires careful assessment of the available water resources and reasonable needs of the basin/region in foreseeable future for various purposes such as drinking water, irrigation, hydro-power, navigation, etc. There are several ongoing river water disputes between different states of India, especially in the peninsular region due to decrease in rainfall during the past 15 years or so. The sharing of water of the Mondovi River is a cause of dispute between the Governments of Maharashtra, Karnataka and Goa states. An attempt has therefore, been made to study the characteristics of rainfall distribution over the Goa state using daily and monthly rainfall data. The study mostly comprises of spatial distribution of rainfall, seasonal and annual rainfall trend, relationship between rainfall and rainy days, mean daily rainfall intensity (MDI) and yearly variation of rainfall as well. The results of this study would form basis for various studies in administrating fresh water sources, projecting the investments to prevent the urban areas from the flood and proper planning of the agricultural activities in the State.

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Human female- derived osteoblast- like cells in culture (hObs) and the cell lines (SaOS2 and hFOB) express mRNAs involved in bone biology and physiology such as estrogen receptor α (ERα) and α (ERα), vitamin D receptor (VDR), 1α, 25 (OH) vitamin D3 hydroxylase (1OHase) and 12 and 15 lipoxygenases (12LO and 15LO). These mRNAs are modulated by estrogenic compounds. Since the skeletal protective effects of estrogens are not discernible in diabetic women, we tested the estrogenic modulations of these parameters in cells grown in growth medium containing high glucose (HG; 9.0g/L; 44mM) compared to normal glucose (NG; 4.5g/L; 22mM). HG significantly increased DNA synthesis (DNA) and creatine kinase specific activity (CK). Stimulations of DNA but not of CK by estradiol-17β (E2), by 4, 4’, 4’’-[4-propyl-(1H)-pyrazol-1, 3, 5- triyl] tris-phenol (PPT; ERa specific agonist), or by 2, 3-bis (4-hydroxyphenyl)-propionitrile (DPN; ER β specific agonist), were modulated by HG. HG Itself up regulated the expression of mRNA of 12LO and 15LO and to less extent ERβ and VDR, but had no effect on ERα and 1OHase mRNA expression. The different hormonal treatments modulated the expressions of VDR, 1OHase, 12LO and 15LO mRNAs which were reduced in HG, whereas the induction of their products 1α, 25 dihydroxy-vitamin D3 (1,25D) and 12- and 15- hydroxyeicosatetraenoic acid (12 and 15 HETE) were only slightly affected by HG. The exact mechanism of HG effects on bone cell responses and its relationship to human bone physiology is not yet clear.

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Ticodendron incognitum the only species of the Ticodendraceae family was discovered in Costa Rica in 1989 and currently there are no reports on its chemical composition or biological activity.

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Significant work has been attempted to better comprehend the attributes and mechanisms suggested in simulation and data mining in precedent research. More prominent understanding causes not only give progresses in numerous fields but also enable experts to better consider the last target.

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This study was conducted to investigate the complete anatomy of the interforaminal area of the mandible. For the correct acknowledgement of the anatomical structures in this region is necessary, since it is especially important for planning implants. The CBCT and PAN images of 200 patients, taken for general dental diagnoses, were examined with regard to the mandibular incisive canal. The panoramic images were obtained using radiographic equipment Toshiba Corporation, J. Morita Mfg. Corp., Kyoto, Japan, while the cone-beam computed tomography dental imaging system GALILEOS, Sirona Dental Systems, Bensheim, Germany was operated.

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Attribution of etiology for disease syndromes is critical to guide appropriate public health interventions. Partial latent class analysis model (pLCM) methods have recently been developed to address this area of research; however, model parameters, assumptions, and performance are not well understood for the general etiology problem.

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The effect of alcohol consumption on overall cancer incidence is not clear. The aim of the paper is to estimate the impact of alcohol consumption on risk distribution of the 20 most common cancer types among men and women in the Western world. A meta-analysis of relative risks for the 20 most common cancer types potentially associated with alcohol consumption in the Western world was conducted based on the most recent cancer specific meta-analyses. Cancer risks were compared between men and women applying a sigmoidal dose response model. Drinking 2.5-14.9 g alcohol/day was associated with a small decrease in overall cancer incidence: 0.977 for men and 0.974 for women; followed by a small increase in the 15-29.9 g/day category: 1.029 for men and 1.077 for women. Further increases were observed in the 30-60 g/day category indicating a 5 and 10% increase in overall cancer risk for men and women, respectively. Women appeared to be more sensitive: the alcohol consumption level to acquire overall risk increase is 22 g/day for women and 46 g/day for men.

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The application of electronic-nose (E-nose) technologies in forensic science is a recent new development following a long history of progress in the development of diverse applications in the related biomedical and pharmaceutical fields. Data from forensic analyses must satisfy the needs and requirements of both the scientific and legal communities. The type of data collected from electronic-nose devices provides a means of identifying specific types of information about the chemical nature of evidentiary objects and samples under investigation using aroma signature profiles of complex gaseous mixtures containing volatile organic compounds (VOCs) released from manufactured products and parts of the human body. E-nose analyses also provide useful qualitative information about the physicochemical characteristics and metabolic conditions of human subjects without the need for time-consuming analyses to identify all chemical components in human-derived volatile mixtures.

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Carbon nanotube (NT) based electronic vapor sensors were tested against synthetic sweat solutions, consisting of 13 volatile organic compounds (VOCs) in saline, in order to probe the device ability to analyze and differentiate vapors derived from complex biological samples.

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The collection of human odor volatiles is of interest to forensic applications as a path to investigate canine scent discriminations in legal investigations. A study using a selected array of previously identified human odor compounds has been conducted to determine the retention and release capabilities of five (5) natural and synthetic fabric types, cotton (mercerized fabric and gauze matrix), polyester, rayon and wool.

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