Articles Related to angiosarcoma
Immunohistochemical Localization of LH Receptors in Canine Splenic Hemangiosarcoma
Gonad removal has been implicated as a risk factor for the development of canine hemangiosarcoma. With gonad removal, there is a loss of negative feedback to the anterior pituitary, resulting in persistently elevated concentrations of luteinizing hormone (LH). LH receptors can be found in gonadal and extragonadal tissues, including the bladder and skin. The aim of this study was to investigate if LH receptors were expressed in canine splenic hemangiosarcoma. Splenic tumor samples submitted to the Oregon State Veterinary Diagnostic Laboratory from referring veterinarians were with routine immunohistochemical methods. In addition, survival time following hemangiosarcoma diagnosis was obtained from the referring veterinarians. Five of the eight splenic hemangiosarcomas (62.5 %) were positive for LH receptor expression. LH receptor cellular localization in splenic hemangiosarcoma was cytoplasmic and granular, similar to the positive control canine skin sections (Figure 1C). There was no positive staining in the negative controls. LH receptor is expressed in a proportion of HSAs but further study need to be done to assess the significance of this finding.
Hepatic Angiosarcoma, going but not gone. Lessons from a single centre experience
Hepatic angiosarcoma is a rare tumour that is often difficult to diagnose. Historically, most cases of hepatic angiosarcoma were seen in the setting of industrial epidemics caused by exposure of workers to toxins such as vinyl chloride. Cases associated with recognised exposure to carcinogens have fortunately been extremely rare for the last three or more decades.