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Articles Related to chronic

The Effect of Salbutamol Nebul Treatment on Systolic Pulmonary Artery Pressure in Newly Diagnosed Patients with Chronic Obstructive Pulmoner Disease

The occurrence of pulmonary hypertension [PHT] in patients with chronic obstructive pulmoner disease [COPD] usually indicates progression of the disease and poor prognosis. The aim of this study is to investigate the effect of oxygen and bronchodilator treatment on systolic pulmonary artery pressure induced by exertion test in patients with COPD.
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Clinical and Paraclinical Profile of Patients in First Nephrology Consultation at the Aristide Le Dantec University Hospital Center (ALD-UHC) About 542 Cases

Late recourse to nephrology consultation remains a topical issue which concerns both developed and developing countries such that a majority of the patients are seen to be at an advanced stage of chronic kidney diseases. The aim of this study is to assess the clinical and paraclinical profile of patients referred for primary nephrological consultation.
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Differential Expression of Proteins Associated with Chronic Hepatitis B Virus Infection on HeLa cell lines

Treatment of Hepatitis B infection is available with the help of existing drugs but the eradication of HBV infection is still under the pipeline. The application of novel drugs and gene-based therapies for HBV infection in need of the hour, however, the lack of efficient cell culture system, animal models for viral infection and replication acts as a major obstacle for novel therapies. This not only hampers the progress of HBV research but also stress the need for effective forthcoming therapeutics for Hepatitis B infection. Proteomic studies to understand the protein ubiquitination and to find molecular markers are the effective tools to study the HBV infection, pathogenesis and its control.
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Positive Efficiency of Combine Immunotherapy in Immunocompromised Girls with Recurrent Nonspecific Chronic Vulvovaginitis

Nonspecific chronic vulvovaginites (NCVV) are a frequent clinical sign of immune deficiency, especially in young girls. The established problems with the functioning of various parts of the immune system (IS) in this pathology dictate the need to include immunomodulatory therapy into the complex. The developed program of combined immunotherapy for immunocompromised girls allows reducing the severity and duration of exacerbation of NCVV, their frequency against the background of a significant reduction in ARVI incidence. Positive clinical effects were observed with underlying restoration in IS functioning. A protective effect was obtained (observation in a catamnesis for 1 year): the duration of a clinically safe period increased from 6 to 11-11.5 months per year.
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How to select Tyrosine Kinase Inhibitor for the patients with newly diagnosed Chronic Myeloid Leukemia?

The clinical outcomes of chronic myeloid leukemia (CML) have been improved by tyrosine kinase inhibitors (TKIs). However, there is no established consensus for TKI selection in de novo CML. We investigated TKI treatment patterns in a real-world setting. Among 95 chronic-phase CML patients, 44% were initiated treatment with imatinib, 26% with dasatinib, and 30% with nilotinib. Our data suggest that imatinib remains applicable and that dasatinib has a favorable therapeutic effect, although pleural effusion can arise. Nilotinib was the most prevalent TKI as the treatment-associated adverse events were deemed more manageable than those associated with imatinib and dasatinib.
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Chronic Cough in Children with Rhinosinusitis Associated with Allergic Rhinitis and Rhinosinusitis Alone

Postnasal drip is one of the main causes of Upper Airway Cough Syndrome (UACS). Whether antibiotic targeted on rhinosinusitis accompanying UACS and chronic cough led to an improvement in a cough is controversy. Fifty-five schoolchildren, aged 4 to 14 years, were randomized into two groups: (1) Rhinosinusitis with allergic rhinitis, n = 20 (2) Rhinosinusitis alone, n = 35. The Spirometry, Forced Expiratory Volume in one second (FEV1), Forced Expiratory Flow (FEF) 25-75%, and Fractional Exhaled Nitric Oxide (FENO) were performed in all participants to rule out asthma or airway hypersensitivity. A pediatric allergist examined and recorded the clinical features, including stuffy nose, nasal discharge, postnasal drip, cough, facial, and halitosis. In addition, one senior radiologist examined and reported the results of water’s view and chest plain film for all schoolchildren. Both groups were given Amoxicillin/clavulanic acid twice a day for two weeks.
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The Use of Gingipain DNA Vaccine Against Virulence of Porphyromonas Gingivalis: A Literature Review

Porphyromonas gingivalis (P. gingivalis) is a primary etiologic agent of generalized aggressive and chronic forms of periodontitis. It releases toxins called ‘gingipains’.Gingipains, (Arginine-and Lysine-specific cysteine proteinases) are proteases that are critical virulence factors in progression of periodontitis and degradation of cytokines expressed during inflammation. HRgpA and RgpB (products of two distinct but related genes) induce vascular permeability by activation of the kallikrein/kinin pathway and activating the blood coagulation system which in turn induces gingival crevicular fluid production and progression of inflammation leading to alveolar bone loss.
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Genetic Polymorphisms Associated with Risk of Developing Age-Related Macular Degeneration in Patients with Chronic Aspirin Usage

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population. Aspirin usage has been reported to be associated with an increased risk of developing this disease. This study aims to determine whether the increased risk of AMD with chronic aspirin usage is related to genetic polymorphisms in the Vascular Endothelial Growth Factor A (VEGFA) and Catechol-O-Methyltransferase (COMT) genes.
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Tomotherapy Treatment of Chronic Lymphocytic Leukemia and Ocular Lymphoma

A sixty-five-years-old male patient with history of non-Hodgkin’s lymphoma of the right orbit and a fifty-years-old female patient with chronic lymphocytic leukemia with peripheral lymphocytosis were treated on TomoTherapy. In the first case, a 1 cm beam was used for planning a delivery of 30.6 Gy in 17 fractions with a sequential boost of 9 Gy in 5 fractions. Tumor involvement of the ipsilateral lens and lacrimal gland in the planning target volume necessitated a compromise between preserving patient’s vision and delivery of tumoricidal dose to the target. In the second case, 30 Gy in 20 fractions delivery was planned with a 2.5 cm beam. The tumor extended anteriorly and this technique allowed sparing more orbital tissue and required a high modulation factor.
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Chronic Pain – Can It Be Cured?

Chronic pain is currently treated with several drugs and therapies that can be helpful, but usually do not cure chronic pain. In fact, many drug therapies make the pain worse or are toxic to the patient. Chronic pain treatment frequently involves oral or injected drugs because the perception is that chronic pain comes from an internal source. Chronic pain, and all other forms of pain, should be treated in the skin. Mechanisms of induction of chronic pain will be discussed and skin targets for the treatment and cure of chronic pain will be presented.
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The Evaluation of Functional Mobility Chronic Hemiparetics Submitted to Group Physiotherapy in the Training Circuit Format

Objective: To evaluate the functional mobility of chronic hemiparesis sufferers who undergo 12 weeks of GPCT. IntroductionMethod: We selected 10 chronic hemiparetic patients, aged 21 or over with a medical referral and one-sided hemiparesis with an injury time of ≥12months, capable of walking with or without help and having the ability to perform walking tests. Interviews to collect personal data were conducted, which were then evaluated by Time up & go (TUG) which recorded the time taken for the patient to stand up from a chair, walk 3 meters, return and sit constituting the initial assessment (AV1) and after 12 weeks of intervention with GPCT the final evaluations were taken (AV2).
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Infective Endocarditis at Tricuspid Valve in CHD: What are its Characteristics? What is the Pathophysiology?

Infective endocarditis (IE) is a serious infectious disease that carries a high mortality rate. We report the case of 74-year-old female who is a chronic hemodialysis patient, and was presented with tricuspid valve endocarditis (TVIE) with central venous catheter, due to an Enterobacter Cloacae, which is a non-HACEK Gram-negative bacilli (GNB) and has been reported to be an extremely rare pathogen of IE. The patient was treated with imipenem and teicoplanin for a four-week period, with negative Blood culture and normal C reactive protein (CRP) levels at the end. The aim of our study is to understand the pathophysiology of the IE in chronic renal failure (CRF) especially at the tricuspid valve (TV), and to determine the clinical, biological characteristics and therapeutic modalities.
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Complex Chronic Patients and Atrial Fibrillation: Association with Cognitive Deterioration and Heart Failure

In developed countries, around 3-5% of the people could be identified as chronic complex patients, and they are increasingly at risk of atrial fibrillation (AF) and cognitive impairment. The main objective of this study was to present the current findings on the association between AF and cognitive impairment and mortality risk among chronic complex outpatients (CCP). A multicenter and prospective cohort study of mortality incidence was carried out from 1 January 2013 to 30 September 2016 in a sample of 932 adult patients registered as CCP. To predict hazard ratios, mean survival time, and survival probabilities, a multivariate Cox regression was used.
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Treatment of Chronic Back Pain with Radiculopathy by Selective Nerve Root Block or Pulsed Radiofrequency - Randomised, Open Label, Clinical Trial

Lumbosacral radicular pain (LRP) is a common symptom, its annual prevalence in the general population is reported to be from 9.9% to 25% and it is characterized by a shooting, radiating pain to one or more dermatomes, which is often caused by irritation of the corresponding nerve root. The initial treatment should be conservative with oral medications, exercise, and physiotherapy. When conservative treatments fail, epidural steroid injections and other interventional treatments should be considered. Surgical interventions are indicated when all other treatments have failed.
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Syncope in Chronic Constitutional Hypotension: Gender based Retrospective observational study in symptomatic women

The association between chronic constitutional hypotension (CCH) and symptoms is uncertain both as pathophysiological correlation as a statistical link. The study was undertaken in order to investigate the existence of a significant association between CCH and symptoms and identify the most represented ones.
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Editorial Board Members Related to chronic

Joseph Alpert

Professor
Department of Medicine
University of Arizona
United States

Ock K. Chun

Assistant Professor
Department of Nutritional Sciences
University of Connecticut
United States

ALI H. MOKDAD

Professor of Global Health
Institute for Health Metrics and Evaluation (IHME)
University of Washington
United States

DAVID R. BLACK

Professor Emeritus
Department of Health and Kinesiology
Purdue University
United States

OMAR A. OBEID

Professor of Human Nutrition
Department of Nutrition and Food Science
American University of Beirut
Lebanon

Aladin M Boriek

Professor
Department of Medicine
Baylor College of Medicine
United States

Frank F. Seghatol

Assistant Professor
Division of Cardiology
University of Alabama
United States

Tarik Kivrak

Assistant Professor
Department of Cardiology
Firat University Hospital
Turkey

SALEH A. NASER

Professor of Medicine and Graduate Coordinator
Burnett School of Biomedical Sciences
University of Central Florida
United States

Joseph Prandota

Emeritus Full Professor
Department of Pediatrics & Clinical Pharmacology
Faculty of Health Sciences
Wroclaw Medical University
Wroclaw
Poland
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