Articles Related to clinical
The Efficiency and Safety of a Resveratrol and Alpha Lipoic Acid Combination in the Prevention of Gestational Diabetes Related Complications: A Retrospective Clinical Trial
Gestational diabetes mellitus (GDM) is associated with an increased maternal and fetal risk of complications. Other than
lifestyle modifications and diet, little prevention can be done towards this maternal complication. Through a preclinical approach and a retrospective clinical trial, we investigated the effects of maternal supplementation with a nutraceutical composition based on resveratrol (RSV) and alpha-lipoic acid (ALA) on insulin resistance and GDM status
Assessment of Changes in Clinical Management of Cervical Cancer Patients in Light of New Staging Criteria
Objective: To assess the changes in the Current clinical management of cancer cervix patients as the new staging considers
radiological and pathological criteria for cervical cancer staging.
Methods: This retrospective study Retrospective collection of the Data from the medical records.
Results: Five hundred and nine Patients were registered for cervical cancer from Jan 2019 to December 2021. The average
age of patients treated was 53yrs. The patients' age distribution ( Table 2 ) was Less than one percent of patients below 30yrs,
31.4 percent, and 40.6 percent were in the 50 to 60 yrs range
Study to Find Clinical Characteristics of ABPA in Patients of Severe Bronchial Asthma and Its Relation with Serum Ige Level at Teriary Care Center North India
Allergic bronchopulmonary aspergillosis (ABPA) is an idiopathic inflammatory disease of the lung, characterized by an allergic inflammatory response to colonization of the airways by Aspergillus fumigatus or other fungi. Untreated
or inadequatetreatment may lead to poor outcome in patients. Raised level of serum IgE of more than 1000 IU/ML have
been considered as one if theimportant diagnostic criteria for ABPA, however relation of serum IgE withs severity ofdiseases is lacking. This study was conducted to find out level of serum IgE in patients ofABPA and to find out corelation of
Serum IgE with duration of symptoms and diseasesseverity.
Comparative Assessment of Chest X-ray Interpretations by AI Model and Radiologist Vs Pulmonologist in Predicting the Clinical Status of Covid-19 Pneumonia Patients
Pneumonia is most prevalent and acute respiratory disorder. Chest radiography is the gold standard to confirm
the clinical condition and the progress. The use of AI in diagnostic workflow proved to be useful. In this study, quantitative
assessment by the AI device is compared with the qualitative assessment by the radiologists.
GMP-Compliant Production of a Fluorescent Antibody for in vivo Molecular Endoscopy in a Phase I/IIa Clinical Study in Inflammatory Bowel Disease Patients
Therapeutic response to anti-TNF antibody treatment in inflammatory bowel diseases is strongly influenced by transmembrane tumor necrosis factor (mTNF) expression in the intestinal mucosa. Fluorescent anti-TNF antibodies applied for in vivo molecular endoscopy have shown to be able to quantify mucosal mTNF expression in real-time and predict response to subsequent anti-TNF treatment in individual patients with Crohn’s.
Stroke Mimics: Diagnosis and Management of Patients with Suggestive Clinical Manifestations of Ischemic Stroke
Background and Purpose: Ischemic stroke is a treatable medical emergency. The diagnosis of stroke is mainly clinical and not always so obvious. Intravenous thrombolysis treatment with altepase IV and endovascular treatment have been proved as fist-line beneficial options for eligible patients who have acute ischemic stroke. However, approximately 30% of patients who experience an acute neurological deficit compatible with ischemic stroke fall into the category of "stroke mimics"
Evaluation of The Viability and Phenotipe of Adipose Derived Cells Harvested Using Different Harvesting and Processing Procedures: A Pilot Study
Abstract
Background: Clinical studies demonstrated the efficacy of therapies based on the autologous grafting of adult mesenchymal stem cells to accelerate the healing and regenerative processes of the skin and mesenchymal tissues therefore, this is
considered a valuable approach in the aesthetic rejuvenation treatment to give volume restoration and skin regeneration
effects.
Objective: The aim of this project consists of the evaluation of the cell viability of adipose tissue (AT) harvested using
the Superficial Enhanced Fluid Fat Injection (SEFFI) procedure standardized by the Authors (AG, FPB). The harvesting
procedure was performed using two different cannulas having 0.8 mm and 1 mm side-port holes, respectively. Cells phenotype and ability to adhere to the plastic surface have been analysed. The results have been compared to those recorded
in adipose tissue harvested using a liposuction system and processed with enzymatic digestion (collagenase).
Methods: This study was performed on adipose tissues harvested from 7 patients (6 females and 1 male) with an average
age of 48.5 years with two different techniques and three different cannulas. We compared the cell vitality of every sample
at T0 and T72. Moreover, the samples were analysed to determine the phenotype: cells were incubated with antibodies
anti human against CD90-FITC, CD73-PeCy7, CD44-PE, CD31-PECy5, CD235a- PECy7, CD34-FITC, CD45-FITC and
CD146-FITC and read using the flow cytometer s3e Cell Sorter, BioRad. Results were analysed using the software Flow Jo.
Socio-Demographic, Clinical Characteristics and Blood Lipid profiles of Type 1 Diabetic Patients Followed in Regional Hospitals in The Northern Zone of Cameroon
Background and Objective: In Cameroon, given the galloping growth in the prevalence of diabetes, in particular type 1 diabetes in the northern regions, we undertook this study, with the objective to improve the management of type 1 diabetes by determining the socio-demographic, clinical characteristics and lipid profiles of the patients followed in the care centers of regional hospitals of Maroua, Garoua and Ngaoundere.
Methods: We undertook a descriptive cross-sectional study from 07 August 2018 to 07 May 2019 in the care centers of the regional hospitals. Sociodemographic and clinical data were collected by interview to consent patient through structured questionnaires in the survey sheet. Anthropometric data were also determined during the survey, and the blood was collected in referred laboratory for determination of some lipid profiles parameters.
Results: On a sample of 467 Patient suffering from diabetes, 68 were of type 1, representing a prevalence of 26%. Type 1 diabetes Patients were mostly female (61.8%) and the mean age was 20.72 ± 3.4 years with a high percentage between 20-30 years (51.5%). More than half of our patients were pupils and students, many of them practiced Muslims as religion (58.8%). In most of cases (51.3%), the disease was diagnosed after one year as a result of illness. The majority of our patients were non-smokers (98.5%) and less athletic (32.4%). The mean Body Mass Index (BMI) was 23.03 ± 2.7 kg /m2 with an average waist circumference of 80.26 ± 9.23 cm in men and 82.15 ± 10.45 in women. Their treatment was based essentially on insulin therapy, mainly using regular and intermediate insulins. More than half of the subjects had high blood glucose (78.1%), high triglyceride (34.1%) and HDL-cholesterol (29.3%) levels. Most of the patients suffered from overweight/obesity, high blood pressure, arthritis, kidney failure and other diseases (malaria, jaundice, stomach ache). No significant relation was found between clinical and the sociodemographic and blood lipid profiles.
Conclusion: It emerges from this study that type 1 diabetes represent high proportions of diabetes cases in septentrional area of Cameroon, and affect mostly young of less than 30 years old, dominated by women, practicing Muslim as religion. Their clinical profile characterized by high frequency of overweight/obesity, kidney failure and arthritis vary, but not significantly, with neither their sociodemographic nor their blood lipid profiles. Absence of sport, female and less control of their hypoglycemia are factors risks of the progression of the disease.
Clinical Impact of Laparoscopic Cholecystectomy to Chronic Calculous Cholecy-stitis: A Retrospective Study
The Aims: The retro-prospective clinical study was to compare these two methods of laparoscopic and classical
cholecystectomy. To prove the postoperative benefits of laparoscopic treatment are, less pain, aesthetic aspect without
surgical scarring and shorter hospital stay, faster return to social activities as well as more cost effective.
Material and Methods: The operated patients, from January 2017 to December 2019 in the abdominal surgery ward
in Gjilan. Important data for the study are taken from the operative list, history of the disease, adequate list compiled
specifically for this study. The study included 389 patients with chronic calculous cholecystitis.
Results: According to the results obtained for calculous diseases of the biliary system are predisposed persons with blood
group O, Rh-positive, with 44.2%, followed by group A + with 29.5%, group B + with 14.7%. Other blood groups and
Rh factors are below 6.5%. Statistical point of view is significant (p <0.05). The study analyzed, C-reactive protein (CRP)
values in both research group (RG) and control groups (CG); CRP by gender; and by age group. RG recorded 76.9% of
females with increased CRP values> 6, while 23.1% of males. The percentage difference in statistical terms is significant p
<0.05.
Conclusion: The results obtained have shown that there are no significant differences in the presentation of intra-operative
complications in terms of gender and age, to both methods. Optimization measures for postoperative management of
patients after laparoscopic cholecystectomy. Continuing education in laparoscopic surgery is important for successful
management.
A Java Software for Randomized Phase II Clinical Cancer Trial Designs
Traditionally, a typical phase II trial has been conducted using a single-arm design recruiting patients only to the
experimental therapy to be compared with a historical control. Due to a small sample size and heterogeneity of patient
population, the patient characteristics of the patients in a new phase II trial is often different from that of the selected
historical control, so that the single-arm phase II trial may lead to biased conclusions. A randomized phase II trial
can resolve such problems by randomizing patients between an experimental arm and a control arm. We propose a
software package for designing and analyzing randomized phase II trials.
We develop a user-friendly Java software that will help us find optimal two-stage phase II trial designs. Although the programs accommodate trial designs based on various statistical methods and different types of early stopping rules, the
main part of our paper is focused on randomized phase II trials based on Fisher’s exact test with futility and superiority
early stopping values. If users enter input parameter values, the software generates a graphical output displaying all
efficient two-stage designs. Minimax, optimal, and admissible designs are highlighted as good designs, but users can
select any of the displayed designs. When the circle representing a design is clicked, all the specifics of the selected design
are displayed. Fisher’s test is an exact method whose critical values depend on the total number of responders from two
arms. So, the computations required to search for optimal randomized multi-stage phase II trial designs based on Fisher’s
exact test is very heavy. By using efficient algorithms, our software provides output at almost real time speed
Diabetic Retinopathy, Classification And Clinical Impact
Introduction: Diabetic retinopathy maybe defined as the presence and characteristic evolution of typical retinal micro-vascular lesions to an patient with diabetes. DR usually manifests as a gradual, painless progression of vision loss; however, visual loss may occur with vitreous hemorrhage or macular edema.
Aims: To ascertain the prevalence of diabetic retinopathy (DR) based on the duration of the diabetes mellitus (DM) and to compare it with data from relevant literature and other referent clinics. This exploratory research was conducted to evaluate the clinical experience of DR, its impact of the other disease and health related quality of life. Material and methods: In this study are included the patients with diabetes mellitus type I insulin dependent (DMID) and diabetes mellitus type II non-insulin dependent (DMNID). The duration of diabetes in the examined patients varied from 5 till 30 years. We have applied examination by ophthalmoscope, slit lamp bio-microscopy with Volk and Goldman lens, optical coherence tomography - OCT as well as fluorescent angiography - FAG. Have been included for focus groups (n = 450) the treated patients with DR, from December 2016 - 2020.
Results: Participants described a range of evaluate symptoms and clinical impact. In suffering for a period of 5 years, the prevalence of DR is 12.5%. In diabetic patients suffering over 30 years, the prevalence of DR is over 90.5 %. After the test of PDR impact the comlications results by the X2 -test, the difference was found to be statistically significant for p<0.05.
Clinical Outcome of Different Surgical Techniques for Ossification of Posterior Longitudinal Ligament of the Cervical Spine: A Systematic Review and Network Meta-analysis
Herein, we aimed to compare the neurologic improvement, postoperative complications, and changes of Cobb’s angle between four main surgical approaches, including anterior cervical decompression and fusion (ACDF), laminoplasty (LAMP), laminectomy (LC), and anterior controllable antedisplacement and fusion (ACAF), to treat cervical ossification of posterior longitudinal ligament (OPLL).
The Clinical, Bacteriological and Therapeutic Characteristics of Tuberculosis in Patients Infected with HIV (about 42 Cases)
Tuberculosis still remains a public health priority, especially with the emergence of HIV. It is more and more revealing of the HIV infection. The objective of this study is to analyze the clinical, epidemiological, and therapeutic aspect of tuberculosis in patients infected with HIV.
Correlation of Hemostatic Parameters with Poly (ADP-ribose) Polymerase-1 (PARP-1) Polymorphisms, Mutations, Laboratory, and Clinical Characteristics in 114 Patients with Philadelphia-Negative Myeloproliferative Neoplasms
Patients with Philadelphia-negative myeloproliferative neoplasms (PN-MPN) are at a higher risk for venous thrombosis. Thromboelastometry may prove efficient to evaluate the patient’s thrombotic risk. In this study, based on data from
114 patients with PN-MPN from a single center in Greece, hemostatic profile was assessed with routine coagulation
tests, Rotational Thromboelastometry (ROTEM®
), and Platelet Function Analyzer (PFA)-100 and correlated with clinical,
laboratory, treatment characteristics, gene mutations and polymorphisms of poly (ADP-ribose) polymerase-1 (PARP-1)
ED Patients with Shock have only Few Clinical Characteristics Related to Etiology
The aim of this study is to describe clinical variables and comorbidities in patients with shock, at arrival to the emergency department, and evaluate the diagnostic validity for different shock etiologies. This was a retrospective cohort study with tertiary analysis of data previously published in two other studies. The study population was all patients with shock, arriving to the emergency department at Odense University Hospital between 2000 and 2011. Shock was defined as systolic blood pressure ≤100mmHg and one or more organ failures. Patients were grouped according to discharge diagnoses and this method was manually validated through patient records. The diagnostic value of 26 clinical variables and 10 comorbidities were described and tested.
Editorial Board Members Related to clinical
AHMED NASR
Professor
Department of Obstetrics and Gynecology
Faculty of Medicine
Assiut University
Egypt
Department of Obstetrics and Gynecology
Faculty of Medicine
Assiut University
Egypt
Antonina Argo
Associate Professor
Department of Medical Biotechnology and Forensic Medicine
University of Palermo
Italy
Department of Medical Biotechnology and Forensic Medicine
University of Palermo
Italy
WILLIAM FRAZER MORRIS
Professor
School of Osteopathic Medicine
Campbell University
United States
School of Osteopathic Medicine
Campbell University
United States
Ock K. Chun
Assistant Professor
Department of Nutritional Sciences
University of Connecticut
United States
MICHAEL VAN DOREN JOHNSTON
Professor
Department of Neurology and Pediatrics
Johns Hopkins University School of Medicine
United States
Department of Neurology and Pediatrics
Johns Hopkins University School of Medicine
United States
Jonathan Todd Carter
Associate Professor
Department of Surgery
University of California
United States
Department of Surgery
University of California
United States
Diana L. Eubanks
Associate Clinical Professor
Chief, Community Veterinary Services
Mississippi State University
United States
Chief, Community Veterinary Services
Mississippi State University
United States
Alan Kilistoff
Clinical Professor
Faculty of Medicine and Dentistry
University of Alberta
Canada
Faculty of Medicine and Dentistry
University of Alberta
Canada
MAITRI SHAH
Associate Professor
Department of Obstetrics and Gynecology
Government Medical College
MS University of Baroda
India
Department of Obstetrics and Gynecology
Government Medical College
MS University of Baroda
India