Articles Related to delivery

The transdermal drug delivery system is technique that provides drug through the intact skin. Skin penetration enhancement techniques have been developed to increase the bioavailability of drug substance. These review describes various transdermal patches available in market, types of patches, basic components, polymer used in formulation. The novel drug delivery method do well and complete with those already on the market the main problem that requires consideration include device design and safety, efficacy, ease of handling and economical. Transdermal drug delivery system represent the most attractive method among these because of its low rejection rate, magnificent, ease of administration and better convenience and compliance with patient. This review article provide an overview of transdermal drug delivery system contains various innovative dosage forms. In comparison transdermal patch are effective due to its easy to apply and non-invasive.

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Background: Manifold emulsions are used to increase the bioavailability of active medicinal ingredients and to provide a longer drug delivery mechanism. Hydrophobic and hydrophilic combinational surfactants are frequently used to stabilize the manifold emulsions.

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The term mucoadhesion can be defined as a phenomenon of interfacial molecular attractive forces in the layer of surface of a biological membrane and the natural or synthetic polymer, which allows the polymer to the adhere the surface of that membrane for an extended as well prolonged period of time. Since the last four decades, the conception of mucoadhesion has achieved a important precious interest in the various fields of pharmaceutics

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: Colporrhexis is separation of vaginal fornix from cervix and is a rare but serious cause of major obstetric haemorrhage in women during labor. Immediate clinical diagnosis is difficult but must be anticipated if haemorrhage continues despite contracted uterus following delivery. Rapid resuscitation and decision of laparotomy with either repair or hysterectomy is key in preventing maternal mortality.

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The delivery of the drug at a predetermined controlled rate and its systemic effect is utmost important. Topically administered medicaments in the form of patches is being popular for its effectiveness. The main objective of this research was to formulate matrix-moderated transdermal patch of diclofenac potassium and to evaluate them concerning various in-vitro parameters.

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The aim of the present work was formulation and evaluation of in-situ gelling system of Ciprofloxacin Hydrochloride. The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solution due to rapid precorneal elimination of the drug may be overcomed by the use of in-situ gel forming system that are installed as drop into the eye and undergo sol to gel transition in the cul-de-sac.

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Autism Spectrum Disorders (ASD) is regular heterogeneous neurodevelopmental disorder with symptoms like disability in social association, repetitive behavior interest and activities. Etiology of autism and different speculations of ASD were proposed keeping in mind the end goal to clarify the pathophysiology of ASD.

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According to previous research, delivery is known as an inflammatory process. Recently discovered Adipokine has been proved with an anti-inflammatory and anti-apoptotic role. Hence, this study aimed to investigate changes in maternal Nesfatin-1 concentrations before and after delivery.

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Transdermal drug delivery system has become a proven technology that offer significant clinical benefit over the dosage forms. Drugs with very short half-life, narrow therapeutic window, and poor bioavailability-transdermal drug system are convenient. Skin serves as site of drug application for local as well as systemic effects. There are wide varieties of drugs for which topical or transdermal is viable options

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Intrapartum transabdominal US of the positions of the fetal head recorded during labor could be useful indicator for expecting persistent Occipito Posterior position and labor induction failure.

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Preeclampsia is clinically defined by hypertension and proteinuria, with or without pathologic edema that occurs after 20 weeks’ gestation, but can also present up to 4-6 weeks post-partum. Worldwide, incidence of preeclampsia is 5-14 percent of all pregnancies, while severe preeclampsia can develop to about 25 percent of all cases of preeclampsia.

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The currently available anti HIV agents have several drawbacks such as short half life, low bioavailability, poor CNS penetration and retention, hepatic first pass metabolism, undesirable side effects and frequent dosing regimen.

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Uterine atony is the first cause of haemorrhage at delivery. To prevent post partum major bleeding uterotonic prophylactic drugs are commonly used after caesarean section. Few studies showed an haemostatic activation after oxytocin infusion while no data are available on carbetocin.

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Eugenol (EU) and ibuprofene (IBU) were covalently bound to a bi-functionalized PEG, used as molecular carrier of drugs and the release kinetics of the two bioactive molecules was studied in vitro in buffer solution at pH 7.4, in simulated gastric fluid and in mouse plasma.

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