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Articles Related to disease

Evaluation of Apolipoprotein E Fragmentation as a Biomarker for Alzheimer’s Disease

Recent studies have supported a role for the proteolytic cleavage of apolipoprotein E4 (APOE4) as a potential mechanism for the enhanced dementia risk associated with Alzheimer’s disease. To determine whether APOE4 fragmentation is correlated with AD, ELISA assays were performed with cerebral spinal fluid (CSF) and plasma samples utilizing an antibody that specifically detects a 17 kDa amino-terminal fragment (p17) of APOE (nApoECF antibody). In CSF samples, levels of APOE fragmentation were minimal in both neuropathological normals (NPNs) and AD cases and there were no significant differences between the two cohorts across APOE genotypes.
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Metabolic Syndrome in Indigenous Amerindian Women in Suriname; Less on Waist and More on Weight?

The indigenous Amerindian populations living in the southern interior part of Suriname have to date largely maintained their traditional hunter-gatherer life-style. In this study we compared the prevalence of metabolic syndrome (MeTS) and its component risk factors between indigenous Amerindian women of the interior of Suriname, with indigenous Amerindian women living in the coastal-rural areas who have a more urbanized lifestyle. We focused on women since the Suriname Health study showed that Indigenous women had the second highest MeTS prevalence nationwide.
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Detection of Anti-Trypanosoma Cruzi Antibodies among Donors at A Blood Bank from Southern Mexico, Using an Iron Superoxide Dismutase Excreted (Fe-Sode) as Antigen

Trypanosoma cruzi, the causal agent of Chagas disease in humans, is a widely spread protozoan in Latin America. Chronically infected people are asymptomatic during an indeterminate stage but can represent a significant risk of transmission due to blood donations and organ transplants. Blood transfusion is recognized as the second most important path for transmitting of Chagas disease
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Screening and Basic Workup of a Patient with Peripheral Vascular Disease – A Primer of Physicians

Peripheral vascular disease (PVD) is a prevalent condition associated with significant morbidity and mortality in a variety of patient populations.
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The Importance of Brain MRI in the Diagnosis of Marchiafava-Bignami Disease

Marchiafava-Bignami disease (MBD) is a neurological disorder that has been found to be associated with chronic alcoholism and malnutrition. We report a 45 year old man, chronic alcoholic that developed discouragement for activities involving daily living, changes in retrograde memory in addition to mutism and gait instability. Brain MRI showed central atrophy of the corpus callosum(CC), hypointensity(necrosis) and ventricular dilation(white matter and subcortical region involvement).
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Factors associated with obesity among Saudi women of reproductive age in Jeddah City

Previous studies have shown that women who are overweight or obese are at risk for adverse reproductive outcomes, including infertility, gestational diabetes, and hypertensive disorders of pregnancy. However, information surrounding the risk factors for obesity among Saudi women of reproductive age is deficient due to the limited number of studies that assessed obesity prevalence among them.
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Dental Implant Complications –Systemic Diseases- PART-I

Although dental implants have been a successful option for replacement of lost dentition for nearly five decades, their use in the medical and dental treatment plan is still in its youth. Literature on the medical implications of dental implants is surprisingly sparse, with a need for organization. This review is an attempt to begin the process of documenting the science behind this complex, yet critical topic.
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The Use of Cardiac Resynchronization Therapy in Cancer Patients with Heart Failure

Investigate the use of cardiac resynchronization therapy (CRT) in cancer patients with heart failure (HF); assess factors associated with ischemic and non-ischemic HF. Many newer cancer therapies are cardiotoxic; thus, the incidence of HF has been increasing in this high-risk patient population. CRT has beneficial effects on morbidity, mortality, and left ventricular function in patients with non-ischemic cardiomyopathy, yet cancer patients and survivors who develop severe HF and are eligible for CRT often does not receive it.
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A Case of Bulbar Amyotrophic Lateral Sclerosis with Mild Cognitive Impairment

It is still contentious whether amyotrophic lateral sclerosis (ALS)-Alzheimer’s disease (AD) cases comprise a combined disease or represent a coincidental association. We describe the case of a 78-year-old white male with a 12-month history of bulbar muscle weakness and mild cognitive impairment. Hallmarks of AD pathology were present and associated with diffuse congophilic angiopathy. The motor cortex did not show a loss of motoneurons. The anterior horns of the medulla oblongata and hypoglossal nuclei showed skein-like cytoplasmic inclusions and ubiquitin and TDP43 phosphate positive staining. No signs of FTLD were detected. The pathological results suggest that, in this case, ALS and AD pathology appeared to be independent.
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Assessment of Blood Concentration of Cardiac Troponin I (cTnI) in Healthy Calves and Stocker Calves Effected with Bovine Respiratory Disease Complex

Bovine respiratory disease complex remains one of the most economically important diseases of stocker cattle. Reports of myocardial injury associated with BRDC have been limited to necropsy findings. An animal-side diagnostic test for cardiac troponin I (cTnI) has been validated for use in cattle. The objective of this study was to determine the association of blood concentration of cTnI and pneumonia in stocker cattle. A proof-of-concept study was conducted using 16 calves (7 healthy; 9 BRDC).
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Physical Activity and the Prevalence of General and Abdominal Obesity among Saudi Women of Reproductive Age in Jeddah City

Obesity and physical inactivity are growing problems that are associated with major health problems. However, the current information on the association between obesity and physical activity (PA) in Saudi women of reproductive age is insufficient to design and develop intervention programs. To explore the rates of two types of obesity (general and abdominal obesity) and the level of PA and to evaluate the relationship between obesity risk factors, the use of exercise equipment at home, A cross-sectional study was conducted in 2014 using a stratified two-stage cluster sample. The sampling weight and design effect were incorporated into the analysis. Body mass index (BMI) and waist circumference (WC) data were collected from all participants.and obesity measurements.
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Bubonic Plague Outbreak Investigation in the Endemic District of Tsiroanomandidy - Madagascar, October 2014

Plague remains a major public health problem in Madagascar. Faced with reports of plague cases and deaths in Tsiroanomandidy district, we performed an investigation in October 2014.Our aim was to describe the plague outbreak and to improve the national plague control strategies. We used the National plague control program case definition. We identified cases from outpatient registers and collected socio-demographic and clinical information. Plague circulation was determined through a retrospective environmental survey of rodents and vectors.
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Prevention and Control of Production Limiting Goat Diseases on Small Farms

This article was written in support of development of new strategies to control economically important diseases of goats, and advance the body of knowledge of agricultural professionals and small farmers on disease surveillance and biosecurity for farm operations. The goat industry has been looking for more effective ways to alleviate health problems for a long time. There is an evolving need for scientists, agricultural professionals with expertise in small ruminants, along with the input from goat producers, to develop strategies tailored for specific disease prevalence that affects sustainable small ruminant productions.
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Osteo-Articular Complications in a Pediatric Sickle Cell Disease Population - Imaging Value

Sickle cell disease (SCD) is the most frequent of a group of conditions known as haemoglobinopathies. The disease is an autosomal recessive genetic disorder, characterized by abnormal haemoglobin (Hemoglobin S) that under certain conditions polymerizes resulting in microvascular occlusions. This pictorial review illustrates the osteo-articular manifestations associated with sickle-cell disease encountered in children in our institution with at least one Haematology appointment in 2013/2014. Osteo-articular manifestations with imaging findings were reported in 28 out of 97 patients. The most frequent complications and those that required hospital care were painful vaso-occlusive crisis and femoral head osteomyelitis.
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Lymphoma Complicating IBD Immunomodulator Therapy: A Reminder to be Vigilant

Patients with Inflammatory Bowel Disease (IBD) not responding to steroid treatment should be considered for immunomodulator therapy. The risk of lymphoma in IBD patients treated with immunomodulators is a well-documented but rare complication and remains a subject of controversy. Here, we present two patients treated successfully in outpatient clinics on thiopurine immunomodulators who were admitted within weeks of each other with a diagnosis of lymphoma.
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Electronic-nose Applications in Forensic Science and for Analysis of Volatile Biomarkers in the Human Breath

The application of electronic-nose (E-nose) technologies in forensic science is a recent new development following a long history of progress in the development of diverse applications in the related biomedical and pharmaceutical fields. Data from forensic analyses must satisfy the needs and requirements of both the scientific and legal communities. The type of data collected from electronic-nose devices provides a means of identifying specific types of information about the chemical nature of evidentiary objects and samples under investigation using aroma signature profiles of complex gaseous mixtures containing volatile organic compounds (VOCs) released from manufactured products and parts of the human body. E-nose analyses also provide useful qualitative information about the physicochemical characteristics and metabolic conditions of human subjects without the need for time-consuming analyses to identify all chemical components in human-derived volatile mixtures.
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Editorial Board Members Related to disease

Tatjana Rundek

Professor
Miller School of Medicine
University of Miami
United States

Alcides Troncoso

Professor
Department of Microbiology and Infectious Diseases
University of Buenos Aires
Argentina

Liqing Yu

Associate Professor
Departments of Animal and Avian Sciences
University of Maryland
United States

Baljean Dhillon

Professor of clinical ophthalmology
University of Edinburgh
United Kingdom

Yi Qian

Professor
Biomechanics
Australian School of Advanced Medicine
Macquarie University
Australia

CHIA-YI KUAN

Associate Professor
Department of Pediatrics
Center for Neurodegenerative Disease
Emory University School of Medicine
United States

SIBYLLE KRANZ

Associate Professor
Department of Nutrition Science
Purdue University
United States

Dieter Riethmacher

Associate Professor
Department of Human Genetics
University of Southampton
United Kingdom

Andrew Percy

Genome BC Proteomics Centre
University of Victoria
Canada

Avner Meoded

Neuroimaging Research Fellow
NIH/NINDS
United States
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