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Articles Related to disease

Epidemiological Profile of Congenital Cardiopathy Neonatal Revelation in Tehran

Congenital heart disease is the most common congenital disorder in newborns represents a major cause of perinatal death. The prevalence of these malformations is still unrecognized in Tunisia because of the lack of a national register. The aim of this study was describe the epidemiological and clinical aspects of the heart diseases with neonatal diagnosis in Tunisia.
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Fahr Disease: A Rare Disease That is Diagnosed Incidentally in the Emergency Department

Fahr Disease (FD) is a rare disorder presenting with basal ganglia calcification and its etiology is still unknown. Although, the common cause of the disease is asymptomatic, but it might manifest with neuropsychiatric symptoms. Dizziness is one of the common symptoms at emergency services and mostly it requires advanced examination to establish a final diagnosis. When a neurological condition is suspected to cause dizziness, it is tried to be diagnosed by imaging methods such as Cranial Computed Tomography (CT) and Brain Magnetic Resonance Imaging (MRI), and knowing the relationship between calcification and symptoms will keep the patient away from unnecessary investigations.
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Castleman’s Disease: a Diagnosis to Eliminate in Cases of Cervical Lymphadenopathy

Castleman’s disease is due to a lymphoproliferative disorder by the polyclonal proliferation of B cells inside lymphoid organ.Two types exist: the localized form which is usually benign and multicentric form which is more severe. The main risk is the development of lymphoma. Our aim is to report a case of a 18 years old man patient. Her medical history was unremarkable. She presented with a localized form on the right side of neck lymph node. After the ablation of the nodes,none relapse was noticed.
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The Effect of Salbutamol Nebul Treatment on Systolic Pulmonary Artery Pressure in Newly Diagnosed Patients with Chronic Obstructive Pulmoner Disease

The occurrence of pulmonary hypertension [PHT] in patients with chronic obstructive pulmoner disease [COPD] usually indicates progression of the disease and poor prognosis. The aim of this study is to investigate the effect of oxygen and bronchodilator treatment on systolic pulmonary artery pressure induced by exertion test in patients with COPD.
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Clinical and Paraclinical Profile of Patients in First Nephrology Consultation at the Aristide Le Dantec University Hospital Center (ALD-UHC) About 542 Cases

Late recourse to nephrology consultation remains a topical issue which concerns both developed and developing countries such that a majority of the patients are seen to be at an advanced stage of chronic kidney diseases. The aim of this study is to assess the clinical and paraclinical profile of patients referred for primary nephrological consultation.
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Surveillance of Phytophthora Spp Disease on Pineapple at Specific District of Ethiopia

One of the tropical fruits with high economic value is pineapple. Smooth cayenne (smooth leaf) and Red Spanish (Rough leaf) are the two cultivars of pineapple grown in the world. They grow in the soil and resemble epiphytes in that their roots are intolerant of poor soil aeration.
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Estimation of Pathogen Proportions of Infectious Diseases: Models, Approaches and Evaluations

Attribution of etiology for disease syndromes is critical to guide appropriate public health interventions. Partial latent class analysis model (pLCM) methods have recently been developed to address this area of research; however, model parameters, assumptions, and performance are not well understood for the general etiology problem.
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The Roles of IL-33 and TGF-Β1 in the Pathogenesis of Stevens-Johnson Syndrome/ Toxic Epidermal Necrolysis: Potential Biomarkers for Disease Severity

MicroscopyStevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a disease continuum of potentially life threatening, severe allergic drug reactions which result in cellular apoptosis in the skin, mucous membranes, and ocular surface. The exact pathophysiologic mechanisms leading to this apoptosis is unclear but genetic predisposition and abnormal immune regulations play a role.
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Association between Physical Activity and Body Weight: Health Creation and Disease Prevention

Leisure time physical activity has a broad spectrum of health benefits. The objective of this study was to provide evidence and to support the association between physical activity and body weight. We used data from a probability sample of 8,128 individuals residing in Montreal (Canada). Multinomial multivariate logistic regression was used to determine the association between physical activity and body weight. Results showed no statistical association between physical activity and underweight. However, physical activity was associated with overweight, namely individuals doing less physical activity were significantly more likely to be overweight (OR=1.42; 95%CI=1.18- 1.69) than those performing intense physical activity. Additionally, the association between physical activity and obesity showed a negative incremental relationship, i.e. individuals reporting moderate physical activity were 29% more likely to be obese (OR=1.29; 95%CI=1.07- 1.55), and those reporting low physical activity were 123% more likely to be obese (OR=2.23; 95%CI=1.80-2.76) compared to intense physical activity status. Leisure time physical activity and overweight/obesity were significantly associated after accounting for several socioeconomic, lifestyle and health-related correlates. Due to the broader positive impact of physical activity on the health status of the individual, we advise health authorities to facilitate the propagation of healthy lifestyle in the community by adopting a health-creation policy in addition to the conventional disease-prevention strategy
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Is it Just Shoulder Pain or Insidious Foot Step of Parkinson’S Disease? A Minireview of the Literature

Parkinson’s disease (PD) is a chronic, disabling hypokinetic movement disorder with a broad spectrum of symptomatology including motor and non-motor complaints. Since non-motor symptoms of the disease such as musculoskeletal pain including shoulder pain is often underestimated, and is prone to occur during the course of the disease, as well as the prodromal phase of PD, it is important to keep in mind that shoulder pain may be a foot step of an evolving PD, and may need further investigation in terms of PD.
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Gene Therapy in Sickle Cell Disease

Sickle cell disease is a prevalent and severe monogenic disorder resulting from a homozygous missense mutation in the β-globin gene that leads to polymerization of hemoglobin S. Clinical manifestations of the disease can be critical with considerable morbidity and mortality. One treatment option for the disease is bone marrow transplantation. However this method is restricted to the patients with an appropriately matched donor. Gene therapy by either gene insertion or gene editing, utilizing patient’s own cell is a primary therapeutic option to cure sickle cell disease. However, very less clinical trials have been performed with genetic therapy for treating Sickle cell disease (SCD). Since a couple of decades significant progress has been made in the area of gene therapy for treating monogenic hemoglobin disorders. Numerous therapies are currently in clinical trial stages or in preclinical stages. The safety and efficacy of gene therapy has been greatly improved with the initial use of γ-retrovirus vectors, followed by next-generation lentivirus vectors, and latest gene editing techniques. Although the clinical interpretation of gene therapy has been successful, it involves some limitations including complex cellular abnormalities, inadequate transgene expression, and challenges in achieving effective and persistent inhibition of polymerization of hemoglobin S. This review intends to discuss gene therapy strategies specific to Sickle cell disease, present state of the field, and current status of the gene therapy clinical trials.
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The Impact of Cerebral Amyloid Angiopathy in Lewy Body Dementia: A Neuropathological Study with Magnetic Resonance Imaging Correlations

Cerebral amyloid angiopathy (CAA) is frequently associated to Alzheimer’s disease (AD) but can also occur in Lewy body dementia (LBD). The present post-mortem study compares the incidence and the topographic distribution of small cerebrovascular lesions in LBD brains without and with severe CAA (LBD-CAA).
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Management Protocol for Patients with Down syndrome associated with Alzheimers disease

Down syndrome is one of the most common chromosomal alterations and due to the incremental in the oval life expectancy and its relationship with Alzheimer disease; the professionals have to be aware of the oral and behavioral characteristics to give patients an excellent treatment.
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Productive Cough and Bilateral Ptosis

We present a case report of a patient with Mounier-Kuhn syndrome. The clinical, radiological and endoscopic illustrations contribute to the awareness and recognizability of this rare and under-diagnosed pulmonary syndrome. It is characterized by tracheobronchomegaly and tracheomalacia, leading to ineffective mucociliary clearance, recurrent respiratory infections and bronchiectasis. Computed tomography is the golden standard for diagnosis. Etiology remains unknown. Prognosis depends on adequate treatment and prevention of respiratory infections.
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Pediatric Patient with a Celiac Crisis (Rare Presentation of a Common Disease) Case Report and Literature Review

Celiac disease (CD) is a systemic chronic immune-mediated disorder that is associated with weight loss, diarrhea, and laboratory abnormalities. Celiac disease (CD) is a disease in which the mucosal lining of the small intestine is damaged in response to the ingestion of gluten and similar proteins, which are found in wheat, oats, rye, barley and other grains. Children with CD are very common [1].
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Electronic-nose Applications in Forensic Science and for Analysis of Volatile Biomarkers in the Human Breath

The application of electronic-nose (E-nose) technologies in forensic science is a recent new development following a long history of progress in the development of diverse applications in the related biomedical and pharmaceutical fields. Data from forensic analyses must satisfy the needs and requirements of both the scientific and legal communities. The type of data collected from electronic-nose devices provides a means of identifying specific types of information about the chemical nature of evidentiary objects and samples under investigation using aroma signature profiles of complex gaseous mixtures containing volatile organic compounds (VOCs) released from manufactured products and parts of the human body. E-nose analyses also provide useful qualitative information about the physicochemical characteristics and metabolic conditions of human subjects without the need for time-consuming analyses to identify all chemical components in human-derived volatile mixtures.
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Editorial Board Members Related to disease

Hisao Kurazono

Professor
Department of Animal and Food Hygiene
Obihiro University of Agriculture and Veterinary Medicine
Japan

Stephen Michael Kavic

Associate Professor
Department of Surgery
University of Maryland School of Medicine
United States

Carla J. Kinslow

Principal Consultant
Rimkus Consulting Group
USA

Haider Abdul-Lateef Mousa

Professor
Department of Medical Microbiology
University of Basrah, Iraq
Basrah, Iraq.

Mohsen Meydani

Professor
Friedman School of Nutrition Science and Policy
Tufts University
United States

DAVID R. BLACK

Professor Emeritus
Department of Health and Kinesiology
Purdue University
United States

HONGYU LI

Associate Professor
Department of Gastroenterology
Shenyang Northern Hospital
China

Marc G. Sturgill

Associate Professor and Chair
Department of Pharmacy Practice & Administration
Ernest Mario School of Pharmacy
Rutgers University
United States

Gregory H. Taylor

Associate Professor
Department of Family Medicine
University of Maryland School of Medicine
United States

Peter L. Bordi

Associate Professor
School of Hospitality Management
Pennsylvania State University
United States
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