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Articles Related to disease

The Effect of Salbutamol Nebul Treatment on Systolic Pulmonary Artery Pressure in Newly Diagnosed Patients with Chronic Obstructive Pulmoner Disease

The occurrence of pulmonary hypertension [PHT] in patients with chronic obstructive pulmoner disease [COPD] usually indicates progression of the disease and poor prognosis. The aim of this study is to investigate the effect of oxygen and bronchodilator treatment on systolic pulmonary artery pressure induced by exertion test in patients with COPD.
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Clinical and Paraclinical Profile of Patients in First Nephrology Consultation at the Aristide Le Dantec University Hospital Center (ALD-UHC) About 542 Cases

Late recourse to nephrology consultation remains a topical issue which concerns both developed and developing countries such that a majority of the patients are seen to be at an advanced stage of chronic kidney diseases. The aim of this study is to assess the clinical and paraclinical profile of patients referred for primary nephrological consultation.
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Surveillance of Phytophthora Spp Disease on Pineapple at Specific District of Ethiopia

One of the tropical fruits with high economic value is pineapple. Smooth cayenne (smooth leaf) and Red Spanish (Rough leaf) are the two cultivars of pineapple grown in the world. They grow in the soil and resemble epiphytes in that their roots are intolerant of poor soil aeration.
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Estimation of Pathogen Proportions of Infectious Diseases: Models, Approaches and Evaluations

Attribution of etiology for disease syndromes is critical to guide appropriate public health interventions. Partial latent class analysis model (pLCM) methods have recently been developed to address this area of research; however, model parameters, assumptions, and performance are not well understood for the general etiology problem.
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The Roles of IL-33 and TGF-Β1 in the Pathogenesis of Stevens-Johnson Syndrome/ Toxic Epidermal Necrolysis: Potential Biomarkers for Disease Severity

MicroscopyStevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a disease continuum of potentially life threatening, severe allergic drug reactions which result in cellular apoptosis in the skin, mucous membranes, and ocular surface. The exact pathophysiologic mechanisms leading to this apoptosis is unclear but genetic predisposition and abnormal immune regulations play a role.
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Association between Physical Activity and Body Weight: Health Creation and Disease Prevention

Leisure time physical activity has a broad spectrum of health benefits. The objective of this study was to provide evidence and to support the association between physical activity and body weight. We used data from a probability sample of 8,128 individuals residing in Montreal (Canada). Multinomial multivariate logistic regression was used to determine the association between physical activity and body weight. Results showed no statistical association between physical activity and underweight. However, physical activity was associated with overweight, namely individuals doing less physical activity were significantly more likely to be overweight (OR=1.42; 95%CI=1.18- 1.69) than those performing intense physical activity. Additionally, the association between physical activity and obesity showed a negative incremental relationship, i.e. individuals reporting moderate physical activity were 29% more likely to be obese (OR=1.29; 95%CI=1.07- 1.55), and those reporting low physical activity were 123% more likely to be obese (OR=2.23; 95%CI=1.80-2.76) compared to intense physical activity status. Leisure time physical activity and overweight/obesity were significantly associated after accounting for several socioeconomic, lifestyle and health-related correlates. Due to the broader positive impact of physical activity on the health status of the individual, we advise health authorities to facilitate the propagation of healthy lifestyle in the community by adopting a health-creation policy in addition to the conventional disease-prevention strategy
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Is it Just Shoulder Pain or Insidious Foot Step of Parkinson’S Disease? A Minireview of the Literature

Parkinson’s disease (PD) is a chronic, disabling hypokinetic movement disorder with a broad spectrum of symptomatology including motor and non-motor complaints. Since non-motor symptoms of the disease such as musculoskeletal pain including shoulder pain is often underestimated, and is prone to occur during the course of the disease, as well as the prodromal phase of PD, it is important to keep in mind that shoulder pain may be a foot step of an evolving PD, and may need further investigation in terms of PD.
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Gene Therapy in Sickle Cell Disease

Sickle cell disease is a prevalent and severe monogenic disorder resulting from a homozygous missense mutation in the β-globin gene that leads to polymerization of hemoglobin S. Clinical manifestations of the disease can be critical with considerable morbidity and mortality. One treatment option for the disease is bone marrow transplantation. However this method is restricted to the patients with an appropriately matched donor. Gene therapy by either gene insertion or gene editing, utilizing patient’s own cell is a primary therapeutic option to cure sickle cell disease. However, very less clinical trials have been performed with genetic therapy for treating Sickle cell disease (SCD). Since a couple of decades significant progress has been made in the area of gene therapy for treating monogenic hemoglobin disorders. Numerous therapies are currently in clinical trial stages or in preclinical stages. The safety and efficacy of gene therapy has been greatly improved with the initial use of γ-retrovirus vectors, followed by next-generation lentivirus vectors, and latest gene editing techniques. Although the clinical interpretation of gene therapy has been successful, it involves some limitations including complex cellular abnormalities, inadequate transgene expression, and challenges in achieving effective and persistent inhibition of polymerization of hemoglobin S. This review intends to discuss gene therapy strategies specific to Sickle cell disease, present state of the field, and current status of the gene therapy clinical trials.
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The Impact of Cerebral Amyloid Angiopathy in Lewy Body Dementia: A Neuropathological Study with Magnetic Resonance Imaging Correlations

Cerebral amyloid angiopathy (CAA) is frequently associated to Alzheimer’s disease (AD) but can also occur in Lewy body dementia (LBD). The present post-mortem study compares the incidence and the topographic distribution of small cerebrovascular lesions in LBD brains without and with severe CAA (LBD-CAA).
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Management Protocol for Patients with Down syndrome associated with Alzheimers disease

Down syndrome is one of the most common chromosomal alterations and due to the incremental in the oval life expectancy and its relationship with Alzheimer disease; the professionals have to be aware of the oral and behavioral characteristics to give patients an excellent treatment.
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Productive Cough and Bilateral Ptosis

We present a case report of a patient with Mounier-Kuhn syndrome. The clinical, radiological and endoscopic illustrations contribute to the awareness and recognizability of this rare and under-diagnosed pulmonary syndrome. It is characterized by tracheobronchomegaly and tracheomalacia, leading to ineffective mucociliary clearance, recurrent respiratory infections and bronchiectasis. Computed tomography is the golden standard for diagnosis. Etiology remains unknown. Prognosis depends on adequate treatment and prevention of respiratory infections.
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Pediatric Patient with a Celiac Crisis (Rare Presentation of a Common Disease) Case Report and Literature Review

Celiac disease (CD) is a systemic chronic immune-mediated disorder that is associated with weight loss, diarrhea, and laboratory abnormalities. Celiac disease (CD) is a disease in which the mucosal lining of the small intestine is damaged in response to the ingestion of gluten and similar proteins, which are found in wheat, oats, rye, barley and other grains. Children with CD are very common [1].
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Screening and Identiying Farmers’ Prefered Varieties for Adaptability and Resistance to Cassava Mosaic Disease (CMD) in Sierra Leone

Cassava plays an important role as a food security crop in Sub – Saharan Africa. However, yields of cassava in Sierra Leone are generally low. Adoption of improved varieties resistant to the Cassava Mosaic Disease (CMD) which is one of the most limiting factors of production remains low. Therefore cultivation of local varieties infected with the cassava mosaic disease dominates the farming system in Sierra Leone.
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Health-Related Quality of life of Complete versus Infarct artery-only Percutaneous Coronary Revascularization in Multi-vessel Disease with ST-Segment Elevation Myocardial Infarction

The aim of this study was to evaluate the health-related quality of life (HRQoL) as measured by the EQ-5D (European quality of life-5 dimensions) self-report questionnaire in patients treated with complete revascularization versus infarct artery-only revascularization at index admission.
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Field Assessment of an Immune-Complex Infectious Bursal Disease Vaccine in Chicks Born to Non-Hyperimmunized Broiler Breeders

Prevention of infectious bursal disease (IBD) remains of paramount importance, given the dramatic losses it can induce in commercial chicken flocks. In the Netherlands, maternal immunity is regarded as low, because the parent stock flocks do not receive an inactivated vaccination prior to the onset of production. Therefore, the aim of this field study was to assess the consequences of hatchery vaccination against IBD using an immune-complex vaccine in broiler chicks that were provided with a limited amount of passive immunity. Three grow out cycles in two houses each (six flocks) were monitored after vaccination. The recorded parameters included (i) body and bursa weight, (ii) IBD antibody response, and (iii) histopathology and PCR from the bursa of Fabricius.
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Electronic-nose Applications in Forensic Science and for Analysis of Volatile Biomarkers in the Human Breath

The application of electronic-nose (E-nose) technologies in forensic science is a recent new development following a long history of progress in the development of diverse applications in the related biomedical and pharmaceutical fields. Data from forensic analyses must satisfy the needs and requirements of both the scientific and legal communities. The type of data collected from electronic-nose devices provides a means of identifying specific types of information about the chemical nature of evidentiary objects and samples under investigation using aroma signature profiles of complex gaseous mixtures containing volatile organic compounds (VOCs) released from manufactured products and parts of the human body. E-nose analyses also provide useful qualitative information about the physicochemical characteristics and metabolic conditions of human subjects without the need for time-consuming analyses to identify all chemical components in human-derived volatile mixtures.
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Editorial Board Members Related to disease

Ercument Genc

Professor
Department of Fisheries and Aquaculture Engineering
Faculty of Agriculture
Ankara University
Turkey

Kornélia Tekes

Professor
Department of pharmacodynamics
Semmelweis University
Hungary

Mohd Shahbaaz khan

Assistant Consultant Cardiac Surgeon
King Salman Heart Centre
King Fahad Medical City
Riyadh, kindom of Saudi Arabia
Saudi Arabia

Zhiping Yu

Assistant Professor
Department of Nutrition and Dietetics
University of North Florida
United States

Khaldon Bodoor

Associate Professor
Department of Biotechnology and Genetic Engineering
Jordan University of Science and Technology
Jordan

Akram Mahmoud El-Abd Asbeutah

Assistant Professor
Department of Radiologic Sciences
Faculty of Allied Health Sciences
Kuwait University
Kuwait

Sajjad Pourmozaffar

Assistant professor
Iranian Fisheries Science Research Institute
Iran.

Rashmi Bansal

Professor
Department of Neuroscience
University of Connecticut Health Center
United States

Gregory H. Taylor

Associate Professor
Department of Family Medicine
University of Maryland School of Medicine
United States

Marc G. Sturgill

Associate Professor and Chair
Department of Pharmacy Practice & Administration
Ernest Mario School of Pharmacy
Rutgers University
United States
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