Top Links

Articles Related to disease

Estimation of Pathogen Proportions of Infectious Diseases: Models, Approaches and Evaluations

Attribution of etiology for disease syndromes is critical to guide appropriate public health interventions. Partial latent class analysis model (pLCM) methods have recently been developed to address this area of research; however, model parameters, assumptions, and performance are not well understood for the general etiology problem.
View complete article: PDF  |  Full-text

The Roles of IL-33 and TGF-Β1 in the Pathogenesis of Stevens-Johnson Syndrome/ Toxic Epidermal Necrolysis: Potential Biomarkers for Disease Severity

MicroscopyStevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a disease continuum of potentially life threatening, severe allergic drug reactions which result in cellular apoptosis in the skin, mucous membranes, and ocular surface. The exact pathophysiologic mechanisms leading to this apoptosis is unclear but genetic predisposition and abnormal immune regulations play a role.
View complete article: PDF  |  Full-text

Association between Physical Activity and Body Weight: Health Creation and Disease Prevention

Leisure time physical activity has a broad spectrum of health benefits. The objective of this study was to provide evidence and to support the association between physical activity and body weight. We used data from a probability sample of 8,128 individuals residing in Montreal (Canada). Multinomial multivariate logistic regression was used to determine the association between physical activity and body weight. Results showed no statistical association between physical activity and underweight. However, physical activity was associated with overweight, namely individuals doing less physical activity were significantly more likely to be overweight (OR=1.42; 95%CI=1.18- 1.69) than those performing intense physical activity. Additionally, the association between physical activity and obesity showed a negative incremental relationship, i.e. individuals reporting moderate physical activity were 29% more likely to be obese (OR=1.29; 95%CI=1.07- 1.55), and those reporting low physical activity were 123% more likely to be obese (OR=2.23; 95%CI=1.80-2.76) compared to intense physical activity status. Leisure time physical activity and overweight/obesity were significantly associated after accounting for several socioeconomic, lifestyle and health-related correlates. Due to the broader positive impact of physical activity on the health status of the individual, we advise health authorities to facilitate the propagation of healthy lifestyle in the community by adopting a health-creation policy in addition to the conventional disease-prevention strategy
View complete article: PDF  |  Full-text

Is it Just Shoulder Pain or Insidious Foot Step of Parkinson’S Disease? A Minireview of the Literature

Parkinson’s disease (PD) is a chronic, disabling hypokinetic movement disorder with a broad spectrum of symptomatology including motor and non-motor complaints. Since non-motor symptoms of the disease such as musculoskeletal pain including shoulder pain is often underestimated, and is prone to occur during the course of the disease, as well as the prodromal phase of PD, it is important to keep in mind that shoulder pain may be a foot step of an evolving PD, and may need further investigation in terms of PD.
View complete article: PDF  |  Full-text

Gene Therapy in Sickle Cell Disease

Sickle cell disease is a prevalent and severe monogenic disorder resulting from a homozygous missense mutation in the β-globin gene that leads to polymerization of hemoglobin S. Clinical manifestations of the disease can be critical with considerable morbidity and mortality. One treatment option for the disease is bone marrow transplantation. However this method is restricted to the patients with an appropriately matched donor. Gene therapy by either gene insertion or gene editing, utilizing patient’s own cell is a primary therapeutic option to cure sickle cell disease. However, very less clinical trials have been performed with genetic therapy for treating Sickle cell disease (SCD). Since a couple of decades significant progress has been made in the area of gene therapy for treating monogenic hemoglobin disorders. Numerous therapies are currently in clinical trial stages or in preclinical stages. The safety and efficacy of gene therapy has been greatly improved with the initial use of γ-retrovirus vectors, followed by next-generation lentivirus vectors, and latest gene editing techniques. Although the clinical interpretation of gene therapy has been successful, it involves some limitations including complex cellular abnormalities, inadequate transgene expression, and challenges in achieving effective and persistent inhibition of polymerization of hemoglobin S. This review intends to discuss gene therapy strategies specific to Sickle cell disease, present state of the field, and current status of the gene therapy clinical trials.
View complete article: PDF  |  Full-text

The Impact of Cerebral Amyloid Angiopathy in Lewy Body Dementia: A Neuropathological Study with Magnetic Resonance Imaging Correlations

Cerebral amyloid angiopathy (CAA) is frequently associated to Alzheimer’s disease (AD) but can also occur in Lewy body dementia (LBD). The present post-mortem study compares the incidence and the topographic distribution of small cerebrovascular lesions in LBD brains without and with severe CAA (LBD-CAA).
View complete article: PDF  |  Full-text

Management Protocol for Patients with Down syndrome associated with Alzheimers disease

Down syndrome is one of the most common chromosomal alterations and due to the incremental in the oval life expectancy and its relationship with Alzheimer disease; the professionals have to be aware of the oral and behavioral characteristics to give patients an excellent treatment.
View complete article: PDF  |  Full-text

Productive Cough and Bilateral Ptosis

We present a case report of a patient with Mounier-Kuhn syndrome. The clinical, radiological and endoscopic illustrations contribute to the awareness and recognizability of this rare and under-diagnosed pulmonary syndrome. It is characterized by tracheobronchomegaly and tracheomalacia, leading to ineffective mucociliary clearance, recurrent respiratory infections and bronchiectasis. Computed tomography is the golden standard for diagnosis. Etiology remains unknown. Prognosis depends on adequate treatment and prevention of respiratory infections.
View complete article: PDF  |  Full-text

Pediatric Patient with a Celiac Crisis (Rare Presentation of a Common Disease) Case Report and Literature Review

Celiac disease (CD) is a systemic chronic immune-mediated disorder that is associated with weight loss, diarrhea, and laboratory abnormalities. Celiac disease (CD) is a disease in which the mucosal lining of the small intestine is damaged in response to the ingestion of gluten and similar proteins, which are found in wheat, oats, rye, barley and other grains. Children with CD are very common [1].
View complete article: PDF  |  Full-text

Screening and Identiying Farmers’ Prefered Varieties for Adaptability and Resistance to Cassava Mosaic Disease (CMD) in Sierra Leone

Cassava plays an important role as a food security crop in Sub – Saharan Africa. However, yields of cassava in Sierra Leone are generally low. Adoption of improved varieties resistant to the Cassava Mosaic Disease (CMD) which is one of the most limiting factors of production remains low. Therefore cultivation of local varieties infected with the cassava mosaic disease dominates the farming system in Sierra Leone.
View complete article: PDF  |  Full-text

Health-Related Quality of life of Complete versus Infarct artery-only Percutaneous Coronary Revascularization in Multi-vessel Disease with ST-Segment Elevation Myocardial Infarction

The aim of this study was to evaluate the health-related quality of life (HRQoL) as measured by the EQ-5D (European quality of life-5 dimensions) self-report questionnaire in patients treated with complete revascularization versus infarct artery-only revascularization at index admission.
View complete article: PDF  |  Full-text

Field Assessment of an Immune-Complex Infectious Bursal Disease Vaccine in Chicks Born to Non-Hyperimmunized Broiler Breeders

Prevention of infectious bursal disease (IBD) remains of paramount importance, given the dramatic losses it can induce in commercial chicken flocks. In the Netherlands, maternal immunity is regarded as low, because the parent stock flocks do not receive an inactivated vaccination prior to the onset of production. Therefore, the aim of this field study was to assess the consequences of hatchery vaccination against IBD using an immune-complex vaccine in broiler chicks that were provided with a limited amount of passive immunity. Three grow out cycles in two houses each (six flocks) were monitored after vaccination. The recorded parameters included (i) body and bursa weight, (ii) IBD antibody response, and (iii) histopathology and PCR from the bursa of Fabricius.
View complete article: PDF  |  Full-text

The 2015 Dutch Food-Based Dietary Guidelines on Alcohol Consumption - A Critical Review

Background: Recently the Dutch Health Council has issued a revised alcohol guideline stating: Do not drink alcohol, or if any only drink one glass daily. The current guidelines are intended to obtain the lowest disease burden of the most burdensome diseases in The Netherlands. The current paper aims to estimate the overall impact of alcohol consumption on these diseases.
View complete article: PDF  |  Full-text

Hirsutism will be not Considered as Sign of Progressive Disease after Autologous Transplant in POEMS Syndrome

POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes) syndrome is a rare multisystem disease characterized by plasma cell dyscrasia and overproduction of vascular endothelial growth factor (VEGF). Skin changes are usually multiple cutaneous angiomas, leukonychia, necrotizing vasculitis, cutaneous thickening of sclerodermiform type and hypertrichosis. VEGF is assumed to be useful in monitoring disease activity, because VEGF levels usually decrease after treatment. We described the case of a young woman with POEMS syndrome characterized by hirsutism and hypertrichosis who underwent autologous bone marrow transplantation . Evolutionwas hallmarked by an improvment of radiological signs and biological markers specially VEGF, while hirsutism didn’t regress.
View complete article: PDF  |  Full-text

Dawn of the Biofilm Disease: Highlights about Biofilm in Bone and Joint & Prosthetic Joint Infections Pathogenesis, Diagnosis and Treatment

I present some key considerations of the biofilm disease as part of two complex pathologies such as bone and joint infections and prosthetic joint infections, taking into account the bacterial pathogenic factors to understand the particular nature of these infections, and to achieve an accurate diagnosis and management beyond the antimicrobial therapy. I mention some personal experience of many years in the medical microbiology laboratory and next to the patient’s bed.
View complete article: PDF  |  Full-text

Electronic-nose Applications in Forensic Science and for Analysis of Volatile Biomarkers in the Human Breath

The application of electronic-nose (E-nose) technologies in forensic science is a recent new development following a long history of progress in the development of diverse applications in the related biomedical and pharmaceutical fields. Data from forensic analyses must satisfy the needs and requirements of both the scientific and legal communities. The type of data collected from electronic-nose devices provides a means of identifying specific types of information about the chemical nature of evidentiary objects and samples under investigation using aroma signature profiles of complex gaseous mixtures containing volatile organic compounds (VOCs) released from manufactured products and parts of the human body. E-nose analyses also provide useful qualitative information about the physicochemical characteristics and metabolic conditions of human subjects without the need for time-consuming analyses to identify all chemical components in human-derived volatile mixtures.
View complete article: PDF  |  Full-text


Editorial Board Members Related to disease

Mohammad Reza Movahed

CareMore Regional Cardiology Director of Arizona
Clinical Professor of Medicine
University of Arizona
USA

Itsanun Wiwatanaratanabutr

Assistant Professor
Department of Plant Production Technology
Faculty of Agricultural Technology
Thailand

UDAI P. SINGH

Associate Professor
Department of Pathology, Microbiology and Immunology
University of South Carolina
United States

Walter J. Lukiw

Professor
Neurology, Neuroscience and Ophthalmology
Louisiana State University
United States

Angela Chale

Assistant Professor
Department of Health and Nutrition Sciences
Montclair State University
United States

SARATH CHANDRA JANGA

Assistant Professor
School of Informatics and Computing
Indiana University
United States

Songon An

Assistant Professor
Department of Chemistry and Biochemistry
University of Maryland Baltimore County
United States

Solomon Ike Okosun

Associate Professor
Department of Population Health Sciences
School of Public Health
Georgia State University
USA

Abdelfattah Y. M. Nour

Professor
Department of Basic Medical Sciences
Purdue University
United States

Eva Mischak-Weissinger

Professor
Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation
Hannover Medical School
Germany
Submit Manuscript