Articles Related to drugs
Impaired Driving Associated with the Synthetic Cannabinoid 5F-ADB
Synthetic marijuana compounds are more potent than ∆9-tetrahydrocannabinol (∆9-THC) and are known to produce a wide variety of clinical symptoms including cardiac toxicity, seizures, and death. Erratic driving by a 45 y/o male was witnessed in the fall of 2017 and roadside evaluation of the driver by the responding law enforcement officer concluded that the driver was intoxicated. Comprehensive analysis of the cigarettes by gas chromatography-mass spectrometry detected the synthetic cannabinoid 5-fluoro-ADB (5F-ADB or
5F-MDMB-PINACA). Validated forensic liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods were used to detect the 5-fluoro ADB metabolite 7 (26.37 ng/mL) in the driver’s blood sample. No other drugs were detected. This case report is one of the first to conclusively show that designer synthetic cannabinoids, commonly referred to as “K2” and “Spice”, can significantly impair driving at relatively low concentrations.
A Systematic Review Caenorhabditis Elegans (C. Elegans) - A Host Model Organism to Study Drug-Induced Responses to the Effects of Stimulant and Depressant Drugs
Although there are many researches on drug of abuse behavior using C. elegans as model organism, the precise targets and mechanism shared by C. elegans accompanied with behavioral responses to substance misuse is still scarce. This alternative model for rodents and other animal organism has been used to investigate genetic mechanism and specific genes coding drug-induced behavioral response. However, there is very few papers reported to summarize and analyze findings from original researches to identify target/genes underpinning responses to drug addiction.
Drugs of Abuse and Addiction - Overview and Current Status
Today, both nonprescription and prescription drugs used by people for disease treatment, illicit or reward purposes have diverse effects on health permanently or long-lastingly. The effects may even continue and lead to the death or disabilities in child when a person is no longer use the substance. Substances that cause addiction trigger intense feeling of euphoria then lead to loss of control of self-behavior and perception.
Fatal road accidents in Spain: psychoactive substances in killed drivers in 2014
Road traffic accidents (RTAs) are often related to impairment by alcohol or drugs. The objectives of this study is to present toxicological data on drivers killed in traffic accidents in Spain in 2014 from a sample of 614 drivers and 240 (out of 614) with positive results for alcohol, illicit drugs and psychoactive medicinal drugs.
An Introduction to the Approaches of Novel Drug Delivery Systems for Acquired Immune Deficiency Syndrome (AIDS)
The currently available anti HIV agents have several drawbacks such as short half life, low bioavailability, poor CNS penetration and
retention, hepatic first pass metabolism, undesirable side effects and frequent dosing regimen.
The Ongoing Battle for Syringe Exchange
Syringe exchange programs (SEPs) have been shown to be effective in reduction of infectious disease rates in several studies over the years.
Nutritional and Biological Control Synergism against Gastrointestinal Nematodes in Small Ruminants
Parasitic gastroenteritis caused by gastrointestinal nematodes (GIN) continues to be a major constraint against profitable small ruminant production. The increasing prevalence and severity of anthelmintic-resistant nematodes in many parts of the world has led to a search for non-chemical control options.
Effects of Oxytocin and Carbetocin on Haemostatic Variables in Pregnant Women after Cesarean Section
Uterine atony is the first cause of haemorrhage at delivery. To prevent post partum major bleeding uterotonic prophylactic drugs are commonly used after caesarean section. Few studies showed an haemostatic activation after oxytocin infusion while no data are available on carbetocin.
Canakinumab in the Treatment of Erosive Hand Osteoarthritis: A Case Series
Erosive hand Osteoarthritis (EOA) is a common and debilitating form of hand OA for which there are no proven or efficacious therapies. Interleukin-1 beta (IL-1β) plays a prominent role in OA joint inflammation. Canakinumab is a selective IL-1β inhibitor.
Immunodeficiency and Microbial Infections
Immunodeficiency refers to failure of immune system to encounter infections by different microbial pathogens such as fungi, bacteria, viruses and protozoan. This is called acquired or secondary immunodeficiency syndrome (SIS).
A New Bi-Functional Derivative of Polyethylene Glycol as Molecular Carrier for Eugenol and Ibuprofen
Eugenol (EU) and ibuprofene (IBU) were covalently bound to a bi-functionalized PEG, used as molecular carrier of drugs and the release kinetics of the two bioactive molecules was studied in vitro in buffer solution at pH 7.4, in simulated gastric fluid and in mouse plasma.
Nanotechnology Approaches for Antiretroviral Drugs Delivery
The development of effective drug delivery approaches for the treatment of AIDS and HIV infection is a global challenge. The advent
of multidrug, highly active antiretroviral therapy (HAART), have increased the life span of HIV-infected patients.
Identification of Pyrrolidinophenone-type Designer Drugs by Gas Chromatography/ Time-of-Flight Mass Spectrometry
Use of gas chromatography (GC) combined with time-of –flight mass spectrometry (TOFMS) with soft ionization generated with three different plasma gases (i.e., Xe, Kr, Ar) was evaluated for the identification of several pyrrolidinophenone-type designer drugs that are commercially available.
Nanotechnology Commercialization: Prospects in India
Nanotechnology manipulates and creates matter to formulate nanometer scale materials and objects. It is an interdisciplinary field that involves a wide range of scientific and engineering disciplines, and has societal implications.
Extensive Worm Infestation: A Case Report
Ascariasis is the most common helminthic infection in the world and is seen mostly in the developing countries of Asia. We report a case of heavy worm infestation in a 2-year-old child who presented with worms in small bowel, common bile duct and liver with abscesses. He was managed conservatively and recovered well without any sequalae.
Editorial Board Members Related to drugs
Suresh G. Joshi
Associate Professor
Department of Microbiology and Immunology
Drexel University
United States
Department of Microbiology and Immunology
Drexel University
United States
Muhammad Akram
Associate Professor
Department of Eastern Medicine, Directorate of Medical Sciences
Government College University Faisalabad
Pakistan
Department of Eastern Medicine, Directorate of Medical Sciences
Government College University Faisalabad
Pakistan
