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Articles Related to efficacy

To Evaluate the Efficacy of Ultrasound Guided Distraction Osteogenesis by Evaluating Qualitative Estimation of Bone Fill at Regeneration site and Management of Severe Mandibular Hypoplasia Secondary to Obstructive Sleep Apnoea: A Case Report

Distraction Osteogenesis (DO) is an established method for correction of developmental anomaly of the facial skeleton. The early beginning of urgent surgical corrections are allowed in smaller age as even small children suffering from bilateral severe mandibular deficiency who are often associated with breathing and swallowing disorder caused by glossoptosis.
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Factors Affecting Exercise Self-efficacy in Predialysis Chronic Kidney Disease Patients

There was significant evidence to suggest that exercise improves physical function, symptom burden, and quality of life in predialysis chronic kidney disease (CKD) patients. However, most CKD patients cannot adherence to minimum recommended levels of exercise.
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Epidemiology and Multidrug Resistance of Strongyle Nematodes in Ordos Finewool Sheep

Regular whole-flock treatments and long-term repeated use of similar anthelmintics has led to the development of anthelmintic resistance and widespread epidemic of sheep nematodiasis. The current work was carried out to understand the prevalence of gastrointestinal nematodes in Ordos fine-wool sheep and to evaluate the efficacy of currently used anthelmintics.
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Photodegradation, Antibacterial & Antioxidant Assessment of Multifunctional Zinc Oxide Metal Nanoparticles Using Smilax aspera Leaf Extract: An Eco Approach

The endeavor of this research accounts for a superficial green route scheme by using an extract of leaves of Smilax aspera as a stabilizing and capping agent. Zinc Oxide nanoparticles (ZnO-NPs) were examined through UV-visible Spectrophotometer, X-Ray Diffraction (XRD), EDX (Energy Dispersive X-rays spectroscopy), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM). The NPs demonstrates potential photo catalytic activity for the degradation of Methyl Orange (MO) and Methylene Blue (MB) dyes upon exposure to sunlight.
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Efficacy of Chemical and Organic Fungicides against Spot Blotch Management of Wheat

Spot blotch of wheat caused by Bipolaris sorokiniana is a problematic biotic constraint that causes 15-80% yield abatement in the Indian subcontinent and other parts of the world
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A Novel Neuroprotective and Antioxidative Efficacy of a Unique Combination of Standardized Huperzia serrata, Convolvulus pluricaulis and Celastrus paniculatus Extracts

Physical and environmental stress in conjunction with hectic lifestyle and unhealthy food habits are the major cause of diverse neurodegenerative disorders. Oxidative neuronal injury and acetylcholine deficiency have a major impact on learning and memory retention. Most of the treatment strategies are based on the improvement of cholinergic function in the brain and one of the emerging therapeutic targets is to enhance the acetylcholine level in the brain. Standardized botanical extracts including Huperzia serrata (1% Huperzine A, CogniUp), Convolvulus pluricaulis (SP) and Celastrus paniculatus (JY) have been demonstrated to attenuate brain function by serving as a natural acetylcholinesterase (AChE) inhibitor.
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Clinical Study on the Efficacy of Vipadikahara Grita Taila on the Treatment of Vipadika Skin Disease

Ayurveda has discussed all skin diseases under the name of Kushtha, and in other words it can be known as “Ayurveda Dermatology”. Eighteen types of these skin diseases are mainly divided into seven types of Maha Kushtha and eleven types of Kshudra Kushtha. Vipadika skin disease is diagnosed with the help of critical and analytical study of the literature in original Sanskrit texts and later clinical trial was carried out. In the present study, efficacy of Vipadikahara grita taila was assessed against Vipadika skin disease.
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Efficacy of Purified Glutathione -S- Transferee in Providing Protection against Haemonchus Contortus Infection in Sheep

The efficacy of purified glutathione-s-transferase (GST) to protect sheep against haemonchosis was assessed. Fifteen lambs, 3.5-5month-old, were bisected into five groups (n=3). Two groups were vaccinated with 250μg of each prepared antigen (crude adult antigen (CAA), purified GST) in combination with mineral oil adjuvant at zero, 14th days of the experiment. The other three groups were kept as control groups; non-immunized infected, non-immunized non-infected and adjuvant control. One week after the last booster dose, the lambs in all groups except control negative were challenged with 400 L3/kg live weight orally. Protein characterization of each antigen was done by SDS-PAGE and immunoblting. The vaccine efficacy was estimated by the fecal egg count, where the vaccinated groups showed 58.90% and 79.38% reduction in eggs in CAA and GST respectively. Moreover, 31.45% and 92.10% reduction in abomasal worm count was reported in CAA and GST vaccinated lambs, respectively. The protection was found corresponsive to the sera antibody levels in the immunized groups. It was concluded that the GST had protective efficacy against H. contortus infection in lambs.
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Artisanal Cannabis in Young and Adults Patients with Treatment Resistant Epilepsy: Prospective, Observational, Open-Label Study in Argentina

Background: A third of patients with epilepsy have a drug-resistant form. We aimed to observed whether addition of artisanal cannabis to existing anti-epileptic treatment would be safe, and efficacious in young and adults with drug-resistant epilepsy. Methods: Patients (aged 12-51 years) with severe, intractable epilepsy, who were receiving stable doses of antiepileptic drugs before study entry, were enrolled in an expanded-access programme at our epilepsy centre.
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Efficacy of Chitosan as Vaccine Adjuvant Against Paracoccidioidomycosis in Mice

Paracoccidioidomycosis (PCM) is a systemic disease caused by thermo- dimorphic fungi of Paracoccidioides genus that is endemic in several Latin American countries. The treatment for this disease can be performed with different drugs. In general, it is a long duration treatment that aims the control of the clinical manifestations. Even after treatment, the patient usually shows relapse and incapacitating sequelae, such as fibrosis and pulmonary emphysema.
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Efficacy and Safety of Moxifloxacin-Enhanced versus Standard Sequential Eradication Therapy for Treating Helicobacter pylori Infection among Tobacco Smokers

The therapeutic failure rate of eradication therapy for Helicobacter pylori (Hp) is increasing due to bacterial resistance; tobacco smoking can increase such a rate even more. We explored the role of adding moxifloxacin to the standard sequential eradication therapy for Hp in decreasing the therapeutic failure rate among the tobacco smokers.
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Detecting and Reporting Four Types of Elder Abuse: How Official Adult Protective Services Reports Obscure Older Adults’ Self-Efficacy

It is widely held that older adults are unlikely to self-report their abusive situation to officials such as adult protective services (APS). The purpose of this study was to determine the extent to which older adults self-report or alternatively, disclose to informal sources of support who in turn place official reports. Interviews were conducted with 71 APS caseworkers, 55 of their older clients, and 32 non-abusive persons familiar with the situation. The same person who detected also reported the abuse in only 69% of the cases. While 39.5% of the older victims detected their abuse, only 18.3% also reported the abuse. The remaining older victims disclosed to someone who in turn placed a report. By listening to victim’s voices, it was revealed that at least some older adults exercise considerably more self-efficacy in their abusive situation than official reporting statistics indicate. Implications for research and policy are discussed.
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The Efficacy and Safety of Prophylactic Fluconazole Prevent Invasive Fungal Infection in Preterm Very Low Birth Weight Infants: An Update Meta-analysis

We identified 8 eligible trials that enrolled 1392 infants. There was significant effect of prophylactic fluconazole on fungal colonization (RR, 0.31, 95%C1:-0.24 to 0.41; P<0.00001). Effect of prophylactic fluconazole on IFI in VLBW infants: RR: 0.42(95%CI 0.23 to 0.76; P=0.004.). However, prophylactic fluconazole did not reduce mortality in VLBW infants (RR 0.76, 95% CI 0.58 to 1.01; P = 0.06). Studies did not report significant adverse reactions.
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Comparative Study for Efficacy and Safety of Biosimilar Infliximab in Patients with Active Rheumatoid Arthritis on a stable Dose of Methotrexate

The present study evaluated the efficacy and safety of biosimilar infliximab in patients with active rheumatoid arthritis on a stable dose of methotrexate. Subjects were assigned randomly to either study infliximab or reference infliximab product in an approved dose of 3 mg/kg as an intravenous infusion at week 0, followed by similar doses at Weeks 2, 6 and 14. Primary efficacy endpoint was the proportion of subjects achieving ACR20 criteria at week 16 and secondary efficacy assessment included proportion of subjects achieving ACR20, ACR50 and ACR70 at week 16. In the open-label phase, all responders were followed till week 54. The non-responders entered a follow-up phase for immunogenicity and safety for an additional 3 months.
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Assessment of the Efficacy, Safety and Cost-Effectiveness of Micafungin Compared to Caspofungin and Low Dose Liposomal Amphotericin B for the Treatment of Candidaemia and Clinically Diagnosed Invasive Candidiasis: A Retrospective Audit

Despite several studies having highlighted that candidaemia and invasive fungal disease (IFD) are associated with high mortality and increased costs, there are currently few published studies which provide an insight into real-life practice of invasive candidal diseases. In a medium-sized district general hospital in the UK we sought to compare the efficacy, safety and treatment cost of micafungin versus caspofungin and low dose of liposomal amphotericin B (L-AmB) 1mg/kg/day for the treatment of confirmed candidaemia or clinically diagnosed invasive fungal disease (CDIFD). In the present retrospective audit, a total of 126 patients with candidaemia or CDIFD were reviewed from hospital records and 94 were included in our audit.
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Editorial Board Members Related to efficacy

Richard W. Bianco

Associate Professor
Department of Surgery
University of Minnesota
United States

Jacque Nyenhuis

Assistant Professor
Nutrition and Exercise Sciences
St. Catherine University
United States

CARMEN CASTANEDA SCEPPA

Associate Professor
Department of Health Sciences
Bouvé College of Health Sciences
Northeastern University
United States

Yanyan Li

Assistant Professor
Department of Health and Nutrition Sciences
Montclair State University
United States

Avinash Shankar

Chairman
National Institute of Health & Research
Warisaliganj (Nawada), Bihar
India

VANA SPOULOU

Associate Professor
Department of Paediatrics
University of Athens Medical School
Greece

Tao Liu

Children's Cancer Institute
University of New South Wales
Australia

Alex Kojo Anderson

Associate Professor
Department of Foods and Nutrition
University of Georgia
United States
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