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Articles Related to efficacy

Artisanal Cannabis in Young and Adults Patients with Treatment Resistant Epilepsy: Prospective, Observational, Open-Label Study in Argentina

Background: A third of patients with epilepsy have a drug-resistant form. We aimed to observed whether addition of artisanal cannabis to existing anti-epileptic treatment would be safe, and efficacious in young and adults with drug-resistant epilepsy. Methods: Patients (aged 12-51 years) with severe, intractable epilepsy, who were receiving stable doses of antiepileptic drugs before study entry, were enrolled in an expanded-access programme at our epilepsy centre.
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Efficacy of Chitosan as Vaccine Adjuvant Against Paracoccidioidomycosis in Mice

Paracoccidioidomycosis (PCM) is a systemic disease caused by thermo- dimorphic fungi of Paracoccidioides genus that is endemic in several Latin American countries. The treatment for this disease can be performed with different drugs. In general, it is a long duration treatment that aims the control of the clinical manifestations. Even after treatment, the patient usually shows relapse and incapacitating sequelae, such as fibrosis and pulmonary emphysema.
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Efficacy and Safety of Moxifloxacin-Enhanced versus Standard Sequential Eradication Therapy for Treating Helicobacter pylori Infection among Tobacco Smokers

The therapeutic failure rate of eradication therapy for Helicobacter pylori (Hp) is increasing due to bacterial resistance; tobacco smoking can increase such a rate even more. We explored the role of adding moxifloxacin to the standard sequential eradication therapy for Hp in decreasing the therapeutic failure rate among the tobacco smokers.
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Detecting and Reporting Four Types of Elder Abuse: How Official Adult Protective Services Reports Obscure Older Adults’ Self-Efficacy

It is widely held that older adults are unlikely to self-report their abusive situation to officials such as adult protective services (APS). The purpose of this study was to determine the extent to which older adults self-report or alternatively, disclose to informal sources of support who in turn place official reports. Interviews were conducted with 71 APS caseworkers, 55 of their older clients, and 32 non-abusive persons familiar with the situation. The same person who detected also reported the abuse in only 69% of the cases. While 39.5% of the older victims detected their abuse, only 18.3% also reported the abuse. The remaining older victims disclosed to someone who in turn placed a report. By listening to victim’s voices, it was revealed that at least some older adults exercise considerably more self-efficacy in their abusive situation than official reporting statistics indicate. Implications for research and policy are discussed.
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The Efficacy and Safety of Prophylactic Fluconazole Prevent Invasive Fungal Infection in Preterm Very Low Birth Weight Infants: An Update Meta-analysis

We identified 8 eligible trials that enrolled 1392 infants. There was significant effect of prophylactic fluconazole on fungal colonization (RR, 0.31, 95%C1:-0.24 to 0.41; P<0.00001). Effect of prophylactic fluconazole on IFI in VLBW infants: RR: 0.42(95%CI 0.23 to 0.76; P=0.004.). However, prophylactic fluconazole did not reduce mortality in VLBW infants (RR 0.76, 95% CI 0.58 to 1.01; P = 0.06). Studies did not report significant adverse reactions.
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Comparative Study for Efficacy and Safety of Biosimilar Infliximab in Patients with Active Rheumatoid Arthritis on a stable Dose of Methotrexate

The present study evaluated the efficacy and safety of biosimilar infliximab in patients with active rheumatoid arthritis on a stable dose of methotrexate. Subjects were assigned randomly to either study infliximab or reference infliximab product in an approved dose of 3 mg/kg as an intravenous infusion at week 0, followed by similar doses at Weeks 2, 6 and 14. Primary efficacy endpoint was the proportion of subjects achieving ACR20 criteria at week 16 and secondary efficacy assessment included proportion of subjects achieving ACR20, ACR50 and ACR70 at week 16. In the open-label phase, all responders were followed till week 54. The non-responders entered a follow-up phase for immunogenicity and safety for an additional 3 months.
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Assessment of the Efficacy, Safety and Cost-Effectiveness of Micafungin Compared to Caspofungin and Low Dose Liposomal Amphotericin B for the Treatment of Candidaemia and Clinically Diagnosed Invasive Candidiasis: A Retrospective Audit

Despite several studies having highlighted that candidaemia and invasive fungal disease (IFD) are associated with high mortality and increased costs, there are currently few published studies which provide an insight into real-life practice of invasive candidal diseases. In a medium-sized district general hospital in the UK we sought to compare the efficacy, safety and treatment cost of micafungin versus caspofungin and low dose of liposomal amphotericin B (L-AmB) 1mg/kg/day for the treatment of confirmed candidaemia or clinically diagnosed invasive fungal disease (CDIFD). In the present retrospective audit, a total of 126 patients with candidaemia or CDIFD were reviewed from hospital records and 94 were included in our audit.
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Investigation on Silver Ion Release from Wound Dressings In Vitro and In Vivo

Introduction: In recent years, silver ion based dressings have been widely developed and approved in the market. Meanwhile, methods for selecting appropriate standard models to investigate the silver ion release in vitro and in vivo remains unknown with regard to the safety assessment.Methods and Results: In this study, we have identified that silver ion release in eagle minimum essential mediums(MEM) with 10% fetal calf serum had shown better release kinetics in comparison to other vehicles including simulated body fluid (SBF), 0.9% physiological saline, and 5% glucose.
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An Observational Study on the Clinical Efficacy of Neramexane in Subjective Tinnitus in a Phase 2 Clinical Trial in a Hispanic Cohort in Laredo, Texas

An observational study was conducted on the efficacy of Neramexane in a small cohort of Hispanic subjects who were diagnosed with moderate to severe subjective tinnitus. Patients were screened using the inclusion and exclusion criteria as outlined by the study sponsor. The study protocol involved daily intake of Neramexane 50 mg/day (for weigh<90 kg) or 75 mg/day (weight>90 kg) for 29 weeks with primary efficacy assessed through audiogram study and 3 electronic self-reporting questionnaires: Tinnitus Handicap Inventory-12 (TBF/THI-12) Scale, Tinnitus Rating Scale (TRS) and Hospital Anxiety and Depression Scale (HADS).
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Efficacy of Vitamin C Vaginal Suppository in Treatment of Bacterial Vaginosis a Randomized Controlled Trial

The aim of the current study was to compare the efficacy and side effects of vaginal vitamin C suppository and vaginal metronidazole in treatment of bacterial vaginosis. Double-blind randomized controlled trial. The study included women who presented to the outpatient gynecological clinic with a diagnosis of bacterial vaginosis by amsels criteria. The included eligible women were randomly allocated in one of two groups: group I, including women who received vitamin C vaginal suppository once daily at bed time for 6 days; and group II, including women who received metronidazole 500 mg vaginal suppository once daily at bed time for 6 days. All included women were reviewed in 8-14 days after completion of treatment for reevaluation.
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Efficacy of Fingerprint to Determine Gender and Blood Group

Fingerprint (dermatoglyphic) evidence is undoubtedly the most reliable and acceptable evidence till date in the court of law. Due to the immense potential of fingerprint as an effective method of identification an attempt has been made in the present work to analyze their correlation with gender and blood group of an individual.
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A New Bi-Functional Derivative of Polyethylene Glycol as Molecular Carrier for Eugenol and Ibuprofen

Eugenol (EU) and ibuprofene (IBU) were covalently bound to a bi-functionalized PEG, used as molecular carrier of drugs and the release kinetics of the two bioactive molecules was studied in vitro in buffer solution at pH 7.4, in simulated gastric fluid and in mouse plasma.
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Does Physical Activity and Sport Practice Lead to a Healthier Lifestyle and Eating Habits in Male Adolescents?

The prevalence of childhood obesity has been increasing rapidly and there is general consensus that good nutritional practices and physical activity should be encouraged as early as possible in life. The aim of this study was to describe and to compare the current lifestyle and dietary pattern of normal weight (NW) and overweight + obese (OW+OB) male adolescents who are physically active.
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Anti-Arthritic Efficacy And Safety Of Crominex 3+ (Trivalent Chromium, Phyllanthus emblica Extract, And Shilajit) In Moderately Arthritic Dogs

The present investigation was undertaken to evaluate the therapeutic efficacy and safety of Crominex 3+ (a complex of trivalent chromium, Phyllanthus emblica (Amla) extract and purified Shilajit) in moderately arthritic dogs.
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Anti-Inflammatory and Anti-Arthritic Efficacy and Safety of Purified Shilajit in Moderately Arthritic Dogs

The objective of this investigation was to evaluate the efficacy and safety of purified Shilajit in moderately arthritic dogs. Ten client-owned dogs in a randomized double-blinded study received either a placebo or Shilajit (500 mg) twice daily for a period of five months. Dogs were evaluated each month for physical condition (body weight, body temperature, heart rate, and respiration rate) and pain associated with arthritis (overall pain, pain from limb manipulation, and pain after physical exertion).
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Editorial Board Members Related to efficacy

Richard W. Bianco

Associate Professor
Department of Surgery
University of Minnesota
United States

CARMEN CASTANEDA SCEPPA

Associate Professor
Department of Health Sciences
Bouvé College of Health Sciences
Northeastern University
United States

Yanyan Li

Assistant Professor
Department of Health and Nutrition Sciences
Montclair State University
United States

Tao Liu

Children's Cancer Institute
University of New South Wales
Australia

Jacque Nyenhuis

Assistant Professor
Nutrition and Exercise Sciences
St. Catherine University
United States

VANA SPOULOU

Associate Professor
Department of Paediatrics
University of Athens Medical School
Greece

Alex Kojo Anderson

Associate Professor
Department of Foods and Nutrition
University of Georgia
United States
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