Articles Related to enzymes

Despite extensive research, the incidence of diabetes continues to increase, and the management of diabetes needs improvement, because in 2016, more than 100,000 patients had lower extremity amputated, suffered ischemic heart disease and stroke. Analysis of investigations indicates that increased oxidative stress and chronic inflammation enhance the risk, progression, diabetic–related complications, and reduce effectiveness of drug therapy. Therefore, simultaneously attenuation of these cellular abnormalities may help in reducing the risk of development, progression, and prolonging the effectiveness of drug therapy.

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Multiple myeloma is a malignant disease caused by monoclonal proliferation of multiple myeloma plasma cells [1]. In patients, high-dose melphalan chemotherapy and autologous stem cell transplantation are administered. Common side effects of high dose melphalan are oral mucositis, enteritis, and neutropenia [2].

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The term Myocardial infarction signifies sudden necrosis or death of a portion of cardiac muscle due to an inadequate blood supply. Myocardial infarction results from prolonged myocardial coronary thrombus at the site of a preexisting atherosclerotic stenosis. The major cause of acute myocardial infarction is atherosclerosis. It is three to four times more frequent among men than w]omen.

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This paper aims to review in literature the main mechanisms of oxidative stress, pointing out the major formed metabolites, the mechanisms of cell damage and major antioxidants. Oxygen is essential to human life. The formation of free radicals (FR) is closely related to oxygen consumption, a mechanism that occurs with an incomplete reduction of this molecule.

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The recent resurgence of interest in m6A has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification. The m6A modification is a highly reactive and fluid modification which can respond rapidly to a broad variety of stimuli, and translate these signals into cellular activity. The little information that has been established on its functional capacity has opened up many new avenues of research and has tremendous implications for several fields of study.

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The objective of this investigation was to evaluate the efficacy and safety of purified Shilajit in moderately arthritic dogs. Ten client-owned dogs in a randomized double-blinded study received either a placebo or Shilajit (500 mg) twice daily for a period of five months. Dogs were evaluated each month for physical condition (body weight, body temperature, heart rate, and respiration rate) and pain associated with arthritis (overall pain, pain from limb manipulation, and pain after physical exertion).

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Cancer is a highly heterogeneous disease characterised by continuous uncontrolled growth and expansion of abnormal cells. In general, in tumor cells the signalling pathways regulating cellular processes, as cell growth and division and cell to cellcommunication result strongly altered.

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Mitogen-Activated Protein Kinase (MAPK) pathway is a signal transduction pathway that functions in a wide range of physiological and pathophysiological cellular events including cell proliferation, differentiation, apoptosis, migration, inflammation, metabolic disorders and diseases.

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The discovery of a substance with antibacterial properties was expected to permanently diminish the occurrence of bacterial infections posing a threat to health and life. Since the discovery of penicillin many new groups of antibiotics have been introduced into treatment of disease in people and animals, but their excessive and frequently unjustified use, and most importantly, incorrect dosage, have led to numerous unanticipated problems in contemporary human and veterinary medicine.

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Mycophenolic Acid (MPA) is one of the most widely used immunosuppressive agents in kidney transplantation. This study was designed to compare the safety, tolerability and efficacy of two formulations of mycophenolic acid, Mycophenolate Mofetil (MMF) and Enteric-Coated Mycophenolate Sodium (EC-MPS), in renal transplant recipients.

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