Articles Related to excipient
Comparison of Physicochemical and Binding Properties of Novicel™ Microcrystalline Cellulose and Avicel® PH 101 in Direct Compression of Ascorbic Acid Tablets
Microcrystalline cellulose (MCC) is a key excipient in formulation and production of pharmaceutical solid dosage forms such
as tablets. In this study, the microcrystalline cellulose (Novicel™) obtained from sugarcane bagasse (a waste material from
sugarcane factories) was compared with Avicel PH 101 (a commercially available MCC) for its physicochemical characteristics
and potential as a dry binder in direct compression of ascorbic acid tablets.
Reduction of Bitterness and Enhancing Palatability of Cetirizine Oral Liquid Dosage Forms by Cyclodextrins
The aim of this manuscript is to study cyclodextrins (CDs) as a potential excipient to suppress bitterness and enhance palatability of pediatric liquid preparations for Cetirizine, an extremely bitter drug. Natural α, β and γ CDs; and β CD derivatives such as hydroxyl propyl (HP), randomly methylated (RM) and sulfobutyl ether (SBE) β-CDs were screened in different molar ratios of 1:1, 1:2 and 1:3 for their inhibition of the extremely bitter taste of Cetirizine using the human gustatory sensation test.