Articles Related to fibroblast
Superficial CD34-Positive Fibroblastic Tumor: First Case Report from Latin-America and Review of the Literature
Superficial CD34-positive fibroblastic tumor is an infrequent soft-tissue tumor characterized by a lesion located in the subcutaneous fascia without affecting the soft or deep muscle planes. Its incidence is unknown; therefore, it represents a diagnostic challenge for both the surgical oncologist and pathologist. Given its high risk of local recurrence, extensive surgical resection is the recommended treatment modality. This is the first report of this rare entity in Latin-America.
“Holoprosencephaly, Newly Born Baby Disorder”
This article tell about the recent advances in clinical management of HPE (Holoprosencephaly). HPE is a structural neurological disorder in which brain is unable to divide into their hemispheres and ventricles, basically it is caused due to chromosomal abnormality and a single gene mutation changing trisomy 13 to trisomy 18, on basis of genetics causes patient may suffer with different form of holoprosencephaly including simple to severe form.
Co-culture of Buccal Mucosal Epithelial Cells Downregulate CTGF Expression in Urethral Stricture Fibroblasts
Buccal mucosal urethroplasty has revolutionized the surgical management of urethral strictures but the success of the procedure has been variable in different series. We have attempted to understand the interplay between buccal mucosal epithelial cells (BME) and the fibroblasts at the molecular level using connective tissue growth factor (CTGF) as a marker so that translation of this information would help in better urethroplasty outcomes.
Materials and Methods: The morphological and functional characteristics of normal urethral fibroblasts (NUF) and urethral stricture fibroblasts (UStF) with and without co-culture with BMEs are compared. The intracellular and extracellular level of CTGF expression in the UStF co-cultured with BMEs was analyzed by using molecular biology methods.
Fibromatosis Colli, a Rare Cause of Neck Mass in Infants: A Case Report
Fibromatosis colli is a benign fibrous mass developed from the sternocleidomastoid muscle. The exact etiologies are unknown. It seems that it is due to birth trauma. Ultrasound is the diagnostic tool of choice. The treatment is based on physiotherapy.
Mitochondrial Actions for Fat Browning and Energy Expenditure in White Adipose Tissue
White adipose tissue (WAT) is an endocrine organ with crucial role in the development of obesity and related diseases. White adipocytes have less mitochondria than brown adipocytes; nevertheless, there is an increasing body of evidence showing that mitochondrial parameters play a relevant role in WAT physiology, such as proliferation, differentiation and triacylglycerol storage levels.
Mesenchymal Stem Cells from Different Tissues: Immune Status and Activity
Mesenchymal stem cells (MSCs) have been found in almost all tissues and due to their regenerative properties represent promising tools in cell-based therapy. Role of MSCs in tissue repair is strongly governed by their interplay with immune cells and regulating factors.
Inflammatory Myofibroblastic Tumor of Proximal Urethra in a Pregnant Female: A Unique Case Report
Inflammatory Myofibroblastic tumour (IMT) is a rare spindle tumour that mimics malignant processes. It can affect any part of the body, but rarely occurs in the genitourinary tract. We report a case of urethral IMT in a 31-year-old pregnant female of 18 weeks gestational age.
Molecular Mechanism Linking BRCA1 Dysfunction to High Grade Serous Epithelial Ovarian Cancers with Peritoneal Permeability and Ascites
Ovarian cancer constitutes the second most common gynecological cancer with a five-year survival rate of 40%. Among the various histotypes associated with hereditary ovarian cancer, high-grade serous epithelial ovarian carcinoma (HGSEOC) is the most predominant and women with inherited mutations in BRCA1 have a lifetime risk of 40-60%. HGSEOC is a challenge for clinical oncologists, due to late presentation of patient, diagnosis and high rate of relapse. Ovarian tumors have a wide range of clinical presentations including development of ascites as a result of deregulated endothelial function thereby causing increased vascular permeability of peritoneal vessels.
A Highly Efficient Culture Technique for Derivation of Motor Neurons from Human Umbilical Cord Derived Mesenchymal Stem Cells
Motor Neuron Diseases (MND) are a group of progressive neurological disorders that destroy motor neurons, cells that control essential muscle activity. Despite the advances in treatment modalities, the overall survival rate has not changed for decades. This is mainly due to the lack of effective methods.
m6a RNA Methylation: The Implications for Health and Disease
The recent resurgence of interest in m6A has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification. The m6A modification is a highly reactive and fluid modification which can respond rapidly to a broad variety of stimuli, and translate these signals into cellular activity. The little information that has been established on its functional capacity has opened up many new avenues of research and has tremendous implications for several fields of study.
Juvenile Ossifying Fibroma - WHO Type
Juvenile ossifying fibroma is an uncommon clinical entity, its aggressive local behaviour and high recurrence rate mean that it is important
to make an early diagnosis, apply the appropriate treatment and, especially, follow the patient up over the long term. In the
current article we report a case of juvenile ossifying fibroma-WHO type in 12yr old patient which was clinical and histopathologically
challenging as it was asymptomatic and at an unusual location.
Editorial Board Members Related to fibroblast
Rashmi Bansal
Professor
Department of Neuroscience
University of Connecticut Health Center
United States
Department of Neuroscience
University of Connecticut Health Center
United States