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Articles Related to genetic

Variability of Morphological Markers of Cone and Seeds in Natural Populations and Artificial Plantations of the Scots Pine (Pinus sylvestris L.)

The variability of morphological markers of the reproductive organs in seven natural populations and nine artificial plantations of the Scots pine of Ukrainian Polissya (Volyn, Rivne and Kyiv regions) was studied. The colour of cones, seeds, winged seeds, and the apophysis of the cones of the trees were used as morphological markers.
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Veterinary Considerations for the Theoretical Resurrection of Extinct Species

The de-extinction of the dinosaur is a dubious possibility but its consideration brings forth some issues that are at least worthy of scientific discussion. In this review, we discuss two distinct issues that have implications for a de-extinct species such as a dinosaur: the ability, or lack thereof, to safely sedate a rare and potentially fractious animal capable of harming the veterinary staff tasked with its care; and, disease risks associated with a species that has been extinct for millions of years. To identify potential sedatives, comparative pharmacology will be needed to uncover the links between receptor pharmacology and the desired clinical outcomes of activating established alpha-2 adrenergic, opioid, and benzodiazepine receptors. Specific to disease control, it will be necessary to understand the unique susceptibility of the new species to current diseases as well as predicting their reservoir capacity for potential human and veterinary pandemic diseases. While the topics presented herein are not exhaustive, this review highlights some of the foremost research that should be conducted in order to serve the unique veterinary needs of a de-extinct species using the dinosaur as a paradigm. Addressing these issues should be considered if an intact dinosaur genome becomes available, regardless of the feasibility of dinosaur resurrection.
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Clinical Significance of microRNA Polymorphisms and Expression Profiles in Oral Cancer Development

MicroRNAs (miRNA) are potent regulators, controlling multiple biological processes, including cell growth, differentiation, cell death, development and immune responses. With emerging data supporting that miRNAs play a central role in gene dysregulation in human malignancies, unraveling the miRNA genetic variations in cancer is essential and critical if we want to develop better diagnostic and prognostic system for our patients.
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Analysis of antibody by Real-Valued Special Functions

Along with the rapid development of genetic engineering technology and antibody engineering technology, the humanized monoclonal antibody has been rapidly developed and gradually replaces the rat sourced monoclonal antibody. In this paper, we establish two new logarithmically completely monotonic functions involving the real-valued special functions according to two preferred interaction geometries, necessary and sufficient conditions are presented for one of them to be logarithmically completely monotonic. As a consequence, a sharp inequality involving the real-valued special functions is deduced to solve the problems of genetically engineered antibody.
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Genetic Polymorphisms Associated with Risk of Developing Age-Related Macular Degeneration in Patients with Chronic Aspirin Usage

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population. Aspirin usage has been reported to be associated with an increased risk of developing this disease. This study aims to determine whether the increased risk of AMD with chronic aspirin usage is related to genetic polymorphisms in the Vascular Endothelial Growth Factor A (VEGFA) and Catechol-O-Methyltransferase (COMT) genes.
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Computing intrinsic noise of the genetic regulation modeled by Hill functions

Intrinsic noise embedded in stochastic gene regulation due to low copy number of species has been studied using the approach of theoretical modeling and computational simulation, including the standard methods of stochastic simulation algorithm (SSA) and linear noise approximation (LNA). At average cell level, Hill functions are widely used as a compact format to represent gene regulation involving multi-transcription-factor binding and cooperativity. Heuristic SSA and LNA methods (hSSA and hLNA) have been applied to study stochastic models employing Hill functions. It is however unclear which modeling and simulation method is suitable to characterize intrinsic noise of Hill-type gene regulation with sufficient accuracy and computational efficiency. In this work, we perform noise analysis of two gene regulatory models represented by second-order activating and inhibitory Hill functions, seeking to evaluate the performance of five existing noise modeling methods.
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Envisioning Molecular Network of Obesity by Omics Stratification

To date, Obesity is considered prime concern of public health with multi-dimensional factors engaged in metabolic discrepancy that is rooted from multifactorial causes (i.e., environmental intoxication or genetic abnormality), and the unmet landscape of health care system seeks for therapeutic or preventive measures. Compelling evidence support Omics as strategic tool of systemic biology is benefit to define wiring of molecular circuit in metabolic malfunction and evaluation of metabolic modulator such as synthetic drugs, stem cell replacement, and natural secondary metabolites from various resources.
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Genetic Characterization and Sequence Variations in 12S rRNA of Mitochondrial Gene in Three Indian Civets (Viverridae) Species: Implication in Wildlife Forensics

Comparative genomics of 12S and 16S rRNAs, cytochrome b (Cyt b) and the control region (CR) of mtDNA genome are commonly used in phylogenetics and wildlife forensics. We document the genetic characteristics and sequence variations of 12S rRNA (384 bp) in Indian civets, viz., the common palm civet (Paradoxurus hermaphroditus) (n=9), small Indian civet (Viverricula indica) (n=7) and Himalayan palm civet (Paguma larvata) (n=5). The nucleotide compositions vary from 17.6% to 36.3%, and found one to two haplotypes in all three civet species. Observed sequence divergence was 0.001 to 0.002 and 0.057 to 0.110 within and between species respectively. The nucleotide diversity was 0.00102 to 0.00184. Tajima’s D value was negative (-0.097256 to -1.36240) but statistically non-significant in all three species. Based on genetic characteristics, we discuss the use of observed forensically informative nucleotide sequencing (FINS) and topology in species identification for forensic purposes among these three civet species.
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Responses and Survival under Pegylated Interferon α2a Treatment for Patients with Post-MPN Acute Myeloid Leukemia and Acute Panmyelosis with Myelofibrosis

We report here for the first time the efficacy of pegylated interferon α2a (Peg-Ifn) as a therapy for patients with myelofibrosis and high blast counts. We treated four patients who were in an accelerated phase of myeloproliferative neoplasms or acute panmyelosis with myelofibrosis using only this drug.
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Parry Romberg Syndrome: A Case Report

Parry-Romberg syndrome is a rare disorder characterized by slowly progressive deterioration of the skin and soft tissues of half of the face. The syndrome presents with characteristic skeletal, dental, and soft tissue changes in the affected half of the face, with or without neurological signs and symptoms.
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DNA Methylation Status of the Methylenetetrahydrofolate Reductase Gene is associated with Depressive Symptoms in Japanese Workers: A Cross-Sectional Study

Polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene, that is considered to be the most important genetic determinant of blood homocysteine concentration, are associated with various diseases, including psychiatric disorders. However, the epigenetic factors influencing on the transcription and expression of this gene are unclear.
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Genetic Algorithm and Ensemble Systems for Multi-biometric Cancellable Recognition

Biometrics usually provides several advantages over traditional forms of identity authentication. However, there are some concerns about the security of personal biometric data, while these systems need to ensure their integrity and public acceptance.
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Epigenetic Changes Caused by Occupational Stress in Humans Revealed through Noninvasive Assessment of DNA Methylation of the Tyrosine Hydroxylase Gene

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of L-dihydroxyphenylalanine (L-DOPA), a precursor of dopamine, and is considered to be involved in many aspects of mental health. On the other hand, the epigenetic mechanisms have been recognized as mediators of stable changes in brain function.
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Mthfr c677t, Homocysteine and Risk of Splanchnic Vein Thrombosis: A Pooled Analysis of Published Epidemiological Studies

This meta-analysis aimed to comprehensively assess the literature examining a possible link between the methylenetetrahydrofolate reductase (MTHFR) C677T gene mutation and homocysteine and the risk of splanchnic vein thrombosis (SVT).
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A Highly Efficient Culture Technique for Derivation of Motor Neurons from Human Umbilical Cord Derived Mesenchymal Stem Cells

Motor Neuron Diseases (MND) are a group of progressive neurological disorders that destroy motor neurons, cells that control essential muscle activity. Despite the advances in treatment modalities, the overall survival rate has not changed for decades. This is mainly due to the lack of effective methods.
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Editorial Board Members Related to genetic

Bin Zhou

Scientist
J. Craig Venter Institute
United States

Khue Vu Nguyen

Professor
Department of Medicine and Pediatrics
University of California, San Diego, School of Medicine, San Diego
California, USA

Mayavan Subramani

Postdoctoral Research Associate
Delaware State University
USA.

John V. Planz

Associate Professor
Department of Molecular and Medical Genetics
University of North Texas Health Science Center
United States

Shahzad Shaukat

Virology Department
National Institute of Health
Pakistan

Isik Yulug

Associate professor
Department of Molecular Biology and Genetics
Bilkent University
Turkey

Kaveh Ostad-Ali-Askari

Department of Civil Engineering
Islamic Azad University
Iran

Rodrigo Fernandez Valdivia

Assistant Professor
Department of Pathology
Wayne State University School of Medicine
United States

Chantal ME Tallaksen

Professor
Department of Neurology
University of Oslo
Norway

Bingshan Li

Assistant Professor
Center for Human Genetics Research
Vanderbilt University
United States
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