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Articles Related to genetic

Genetic Characterization and Sequence Variations in 12S rRNA of Mitochondrial Gene in Three Indian Civets (Viverridae) Species: Implication in Wildlife Forensics

Comparative genomics of 12S and 16S rRNAs, cytochrome b (Cyt b) and the control region (CR) of mtDNA genome are commonly used in phylogenetics and wildlife forensics. We document the genetic characteristics and sequence variations of 12S rRNA (384 bp) in Indian civets, viz., the common palm civet (Paradoxurus hermaphroditus) (n=9), small Indian civet (Viverricula indica) (n=7) and Himalayan palm civet (Paguma larvata) (n=5). The nucleotide compositions vary from 17.6% to 36.3%, and found one to two haplotypes in all three civet species. Observed sequence divergence was 0.001 to 0.002 and 0.057 to 0.110 within and between species respectively. The nucleotide diversity was 0.00102 to 0.00184. Tajima’s D value was negative (-0.097256 to -1.36240) but statistically non-significant in all three species. Based on genetic characteristics, we discuss the use of observed forensically informative nucleotide sequencing (FINS) and topology in species identification for forensic purposes among these three civet species.
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Responses and Survival under Pegylated Interferon α2a Treatment for Patients with Post-MPN Acute Myeloid Leukemia and Acute Panmyelosis with Myelofibrosis

We report here for the first time the efficacy of pegylated interferon α2a (Peg-Ifn) as a therapy for patients with myelofibrosis and high blast counts. We treated four patients who were in an accelerated phase of myeloproliferative neoplasms or acute panmyelosis with myelofibrosis using only this drug.
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Parry Romberg Syndrome: A Case Report

Parry-Romberg syndrome is a rare disorder characterized by slowly progressive deterioration of the skin and soft tissues of half of the face. The syndrome presents with characteristic skeletal, dental, and soft tissue changes in the affected half of the face, with or without neurological signs and symptoms.
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DNA Methylation Status of the Methylenetetrahydrofolate Reductase Gene is associated with Depressive Symptoms in Japanese Workers: A Cross-Sectional Study

Polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene, that is considered to be the most important genetic determinant of blood homocysteine concentration, are associated with various diseases, including psychiatric disorders. However, the epigenetic factors influencing on the transcription and expression of this gene are unclear.
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Genetic Algorithm and Ensemble Systems for Multi-biometric Cancellable Recognition

Biometrics usually provides several advantages over traditional forms of identity authentication. However, there are some concerns about the security of personal biometric data, while these systems need to ensure their integrity and public acceptance.
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Epigenetic Changes Caused by Occupational Stress in Humans Revealed through Noninvasive Assessment of DNA Methylation of the Tyrosine Hydroxylase Gene

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of L-dihydroxyphenylalanine (L-DOPA), a precursor of dopamine, and is considered to be involved in many aspects of mental health. On the other hand, the epigenetic mechanisms have been recognized as mediators of stable changes in brain function.
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Mthfr c677t, Homocysteine and Risk of Splanchnic Vein Thrombosis: A Pooled Analysis of Published Epidemiological Studies

This meta-analysis aimed to comprehensively assess the literature examining a possible link between the methylenetetrahydrofolate reductase (MTHFR) C677T gene mutation and homocysteine and the risk of splanchnic vein thrombosis (SVT).
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A Highly Efficient Culture Technique for Derivation of Motor Neurons from Human Umbilical Cord Derived Mesenchymal Stem Cells

Motor Neuron Diseases (MND) are a group of progressive neurological disorders that destroy motor neurons, cells that control essential muscle activity. Despite the advances in treatment modalities, the overall survival rate has not changed for decades. This is mainly due to the lack of effective methods.
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Functional Protein Domains Evolve Very Specifically Over Mutations

Mutation in a single nucleotide of a gene has the potential to change the structure and/or function of its protein. Albeit simply saying, it is not observed to be a general phenomenon. The effect of mutation is primarily determined by the stereochemical nature of the amino acid which has replaced the previous amino acid, resulting in the residue location being affected. Here we show that despite a change in the frequency of occurrence of a particular amino acid in a particular protein in different types of organisms, the overall function of the protein can still remain unaffected, even when the resultant protein conformation is relatively altered.
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Modeling of Gene Regulatory Networks: A Literature Review

In the last years numerous methods have been developed and applied to reconstruct the structure and dynamic rules of gene-regulatory networks from different high-throughput data sources such as gene expression data.
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Folic Acid Supplementation Reduced Depression Score in Young Japanese Women with Depression-susceptible Genetic Polymorphisms

Background: Observational studies have shown that low folate status induces depression. Here we studied the effects of folic acid supplementation on depression scores of Japanese women with depression-susceptible gene polymorphisms: methylenetetrahydrofolate reductase (MTHFR), serotonin transporter (5-HTT), and dopamine D4 receptor (DRD4).
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Molecular Mechanisms of Mismatch Repair Genes in Cancer – A Brief Review

The DNA mismatch repair (MMR) system is necessary for the maintenance of genomic stability. The MMR system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops (IDLs) and heterologies generated during DNA replication and recombination.
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Effects of Transfer Point Glucan #300 Supplementation on Children exposed to Passive Smoking - Placebo-driven Double-blind Clinical Trials

In this study, we focused on the effect of β-glucan supplementation of children with chronic respiratory problems. We measured the levels of cortisol, salivary IgE and cotinine in 56 children and evaluated the effect of 30 day supplementation with 100 mg/day oral dose of yeast-derived β-glucan. Our results showed strong decrease of cotinine and cortisol levels in saliva of β-glucan-supplemented children.
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Unusual Presentation of CML in Pregnancy

Leukemia during pregnancy is rare, posing a complex series of questions, including appropriate therapy and maternalcounseling. Management of chronic myelocytic leukemia (CML) during pregnancy is limited.
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Anti-Arthritic Efficacy And Safety Of Crominex 3+ (Trivalent Chromium, Phyllanthus emblica Extract, And Shilajit) In Moderately Arthritic Dogs

The present investigation was undertaken to evaluate the therapeutic efficacy and safety of Crominex 3+ (a complex of trivalent chromium, Phyllanthus emblica (Amla) extract and purified Shilajit) in moderately arthritic dogs.
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Editorial Board Members Related to genetic

Guo-Zhang Zhu

Professor
Department of Biological Sciences
Marshall University
United States

Guoshun Wang

Associate Professor
Departments of Microbiology and Immunology, Genetics, and Medicine
Louisiana State University Health Sciences Center
United States

Angel Simeonov Galabov

Professor
Department of Virology
The Stephan Angeloff Institute of Microbiology
Bulgaria

Yuehua Cui

Associate Professor
Department of Statistics and Probability
Michigan State University
United States

Valery Soyfer

Professor
Department of Molecular & Microbiology
George Mason University
United States

AMY H. TANG

Associate Professor
Department of Microbiology and Molecular Cell Biology
Eastern Virginia Medical School
United States

VOJTECH HAINER

Associate Professor
Institute of Endocrinology
Obesity Management Center
Prague
Czech Republic

Stefan Mundlos

Professor
Department of Molecular Genetics
Max Planck Institute
Germany

Bin Zhou

Scientist
J. Craig Venter Institute
United States

Guey-Jen Lee-Chen

Professor
Department of Life Science
National Taiwan Normal University
Taiwan
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