Articles Related to hemoglobin
Oxygen Balance Homeostasis and Tissue Metabolic Score (TMS) of Patients in Emergency and Critical Care Medicine
Patients admitted to the emergency room or intensive care units (ICUs) need real-time monitoring of body oxygen balance. As of today, the availability of monitoring devices that provide real-time data on tissue level of oxygen homeostasis is very limited. The involvement of mitochondrial dysfunction in many pathological states such as stroke, sepsis or heart failure is calling for a real-time evaluation of this intracellular organelle. In order to avoid the deterioration of the most vital organs in the body (brain and heart), we are proposing to monitor a less vital organ, such as the urethral wall, that serves as an early warning signal for the deterioration of body oxygen balance.
Sickle cell disease is a prevalent and severe monogenic disorder resulting from a homozygous missense mutation in the β-globin gene that leads to polymerization of hemoglobin S. Clinical manifestations of the disease can be critical with considerable morbidity and mortality. One treatment option for the disease is bone marrow transplantation. However this method is restricted to the patients with an appropriately matched donor. Gene therapy by either gene insertion or gene editing, utilizing patient’s own cell is a primary therapeutic option to cure sickle cell disease. However, very less clinical trials have been performed with genetic therapy for treating Sickle cell disease (SCD). Since a couple of decades significant progress has been made in the area of gene therapy for treating monogenic hemoglobin disorders. Numerous therapies are currently in clinical trial stages or in preclinical stages. The safety and efficacy of gene therapy has been greatly improved with the initial use of γ-retrovirus vectors, followed by next-generation lentivirus vectors, and latest gene editing techniques. Although the clinical interpretation of gene therapy has been successful, it involves some limitations including complex cellular abnormalities, inadequate transgene expression, and challenges in achieving effective and persistent inhibition of polymerization of hemoglobin S. This review intends to discuss gene therapy strategies specific to Sickle cell disease, present state of the field, and current status of the gene therapy clinical trials.
Homocysteine is a parameter that plays an important role for diagnosing several diseases mainly cardiovascular diseases. In this study, the first time reference values for homocysteine levels detected in healthy Golden Retriever, Terrier, German Shepherd and Labrador Retriever breeds of dogs play an important role in the prognosis of many diseases.
Clinical Utility of Triglyceride: HDL-Cholesterol Ratio as a Surrogate Marker of Inflammation in Pediatric Obesity
The prognostic utility of the triglyceride: HDL-cholesterol (TG:HDL-C) ratio, a marker for insulin resistance, is unknown among high-risk children and adolescents. We examined the clinical utility of TG:HDL-C ratio as a marker of insulin resistance and chronic inflammation in obese youth.
Thalassemia is one of the most common genetic disorders worldwide and presents a major public health problem and social challenge in parts where the frequency is high. The symptoms of the disorder are modulated by various environmental, racial and genetic factors. Therefore, dental specialists are obligated to have knowledge towards the nature of the disorder and its effect on dental health. Cooperation with a hematologist is recommended in every dental treatment.
A 60 year-old male presented with fever, malaise, and myalgias. The patient was admitted 3 weeks prior for acute coronary syndrome, underwent coronary stent placement, and was started on clopidogrel.
Hemoglobin A2 (Hb A2) is a minor component of the hemoglobin present in normal adult red blood cells, accounting for 1.5-3.5% of the total hemoglobin in healthy individuals.
A One-Year Hospital Based Prospective Study of Sickle Cell Disease from One Capital Area of Kuwait by HPLC
Haemoglobinopathies are inherited disorders of haemoglobin synthesis that are responsible for significant morbidity and mortality all over the world.
How Should we Screen Overweight and Obese Adolescents for Risk of Type 2 Diabetes in Large Public Health Initiatives?
To develop a valid method to identify insulin resistance (IR) in overweight and obese adolescents without requiring a fasting blood sample.
Congenital Dyserythropoietic Anemia Type III and Primary Hemochromatosis; Coexistence of Mutations in KIF23 and HFE
Congenital dyserythropoietic anemia type III (CDA III) can be caused by mutation in KIF23. CDA III differs from CDA I and II in the sense that secondary hemochromatosis has not been reported. However, we have observed elevated serum ferritin in a CDA III family.
Somatic, inactivating PIGA mutations in haematopoietic stem cells, followed by an unknown autoimmune selection process in favor of the mutated clone, are thought to be important events in the pathogenesis of paroxysmal nocturnal hemoglobinuria (PNH). Recently, a second clonal event involving the HMGA2 gene was reported in some PNH cases, and over expression of this gene was postulated to promote proliferation of the mutated clone.
Glucose Testing and Lifestyle Counseling of Obese and Overweight Patients: A Survey of Primary Care Physicians in the United States
In the United States (U.S.), the costs for health care and lost productivity due to diagnosed diabetes has increased from $174 billion in 2007 to $245 billion in 2012, making it one of the fastest growing public health burdens. Nearly 26 million adults have diabetes, and another 79 million have prediabetes, a condition that increases the risk for developing type 2 diabetes. Clearly to reduce the costs and improve health, preventing diabetes must be a priority.
Coccidioidomycosis involving the larynx is a rare occurrence which seems to present with non-specific upper airway symptoms. The diagnosis is made by tissue biopsy and the treatment is usually fluconazole for 6-12 months depending on the clinical presentation. In unusual presentations of laryngeal problems clinicians should consider Coccidioidomycosis, especially in endemic regions.
Here in a systematic, accurate and reliable method, Head-Space Gas Chromatography-Mass Spectrometry (HS-GC/MS) was developed to determine blood carboxyhemoglobin (COHb%), in order to investigate deaths related to CO exposure especially involving blood and hepatic tissues.
Drug Tolerability and Outcomes in Kidney Transplant Recipients Treated with Two Formulations of Mycophenolic Acid
Mycophenolic Acid (MPA) is one of the most widely used immunosuppressive agents in kidney transplantation. This study was designed to compare the safety, tolerability and efficacy of two formulations of mycophenolic acid, Mycophenolate Mofetil (MMF) and Enteric-Coated Mycophenolate Sodium (EC-MPS), in renal transplant recipients.
Editorial Board Members Related to hemoglobin
Division of Hematology/Medical Oncology University of Missouri
Division of Hematology/Medical Oncology University of Missouri