Articles Related to hereditary
A Rare Case of Albrights Hereditary Osteodystrophy presenting as Recurrent Hypocalcemic Tetany
An internist with an eagle’s eye can diagnose many hidden diseases through careful examination. One such hereditary
metabolic disorder is Albright’s Hereditary Osteodystrophy (AHO). Characteristic presentations in an individual affected
by AHO were short stature, obesity, mild mental retardation and brachydactyly especially of 4th and 5th digits, which
are the phenotypic features of genetic mutation. Pseudohypoparathyroidism (PHP) is characterized by inability of the
body to respond appropriately to parathormone, mainly characterized by hypocalcaemia, increased serum parathormone
concentration, insensitivity to the biological activity of parathormone and hyperphosphatemia. AHO when seen in
association with resistance to parathormone (PTH), it is called PHP. Here is a case report of 22-year-old female patient
with AHO with distinctive physical characteristics who presented to us with recurrent hypocalcaemic tetan
Hereditary Spontaneous Coronary Artery Dissection
SCAD with an estimated prevalence of 1.7% to 4% is an important cause of Myocardial infarction especially in middleaged women with no or minimal cardiovascular risk factors. Diagnosis requires a high degree of suspicion and better coronary imaging. The hereditary/ genetic component has been postulated to play a role, but there is insufficient data on familial SCAD. We present a case of SCAD with probable genetic and autoimmune association.
Hereditary Spherocytosis and Venous Thrombosis of Atypical Site: A Triple Hematologic Disease?
A 22 year-old male with an unspecified family history of hematologic diseases was admitted complaining of chest pain.
Congenital Dyserythropoietic Anemia Type III and Primary Hemochromatosis; Coexistence of Mutations in KIF23 and HFE
Congenital dyserythropoietic anemia type III (CDA III) can be caused by mutation in KIF23. CDA III differs from CDA I and II in the sense that secondary hemochromatosis has not been reported. However, we have observed elevated serum ferritin in a CDA III family.
Parry Romberg Syndrome: A Case Report
Parry-Romberg syndrome is a rare disorder characterized by slowly progressive deterioration of the skin and soft tissues of half of the face. The syndrome presents with characteristic skeletal, dental, and soft tissue changes in the affected half of the face, with or without neurological signs and symptoms.
Langerhans Cell Histiocytosis in a Patient with Lynch Syndrome (Hereditary Non Polyposis Colorectal Cancer)
A fifty three year old white female smoker with Lynch Syndrome was receiving adjuvant chemotherapy for node positive caecal adenocarcinoma. Interval investigations demonstrated a second primary gastric cancer with bilateral pulmonary nodules of indeterminate significance. Lung biopsy revealed Langerhans cell histiocytosis (LCH).
Molecular Mechanism Linking BRCA1 Dysfunction to High Grade Serous Epithelial Ovarian Cancers with Peritoneal Permeability and Ascites
Ovarian cancer constitutes the second most common gynecological cancer with a five-year survival rate of 40%. Among the various histotypes associated with hereditary ovarian cancer, high-grade serous epithelial ovarian carcinoma (HGSEOC) is the most predominant and women with inherited mutations in BRCA1 have a lifetime risk of 40-60%. HGSEOC is a challenge for clinical oncologists, due to late presentation of patient, diagnosis and high rate of relapse. Ovarian tumors have a wide range of clinical presentations including development of ascites as a result of deregulated endothelial function thereby causing increased vascular permeability of peritoneal vessels.
Molecular Mechanisms of Mismatch Repair Genes in Cancer – A Brief Review
The DNA mismatch repair (MMR) system is necessary for the maintenance of genomic stability. The MMR system promotes genomic
fidelity by repairing base-base mismatches, insertion-deletion loops (IDLs) and heterologies generated during DNA replication and recombination.
Editorial Board Members Related to hereditary
Efimia Papadopoulou-Alataki
Assistant professor
Aristotle University of Thessaloniki
Papageorgiou Hospital
Greece
Aristotle University of Thessaloniki
Papageorgiou Hospital
Greece
KELLI BULLARD DUNN
Professor
Department of Surgery
Roswell Park Cancer Institute
University of Louisville School of Medicine
United States
Department of Surgery
Roswell Park Cancer Institute
University of Louisville School of Medicine
United States
Chantal ME Tallaksen
Professor
Department of Neurology
University of Oslo
Norway
Department of Neurology
University of Oslo
Norway
SAN MING WANG
Associate Professor
Department of Genomics
University of Nebraska Medical Center
United States
Department of Genomics
University of Nebraska Medical Center
United States
SANTAMARIA RITA
Associate Professor
Department of Pharmacy
University of Naples Federico II
Italy
Department of Pharmacy
University of Naples Federico II
Italy