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Articles Related to homeostasis

Former Effective Immunotherapy without Adverse Events of Inoperable Epithelial Ovarian Cancers and a Prospect for the Immune Prophylaxis

Current cancer treatments by immune checkpoint blockades are limited due to severe adverse events caused by alteration of the immune system required for homeostasis of normal tissues. Common cancer chemotherapy alters the quality of patients’ lives. Platinum-based treatment can lead to severe neurotoxicity with chronic debilitation. Additionally, survival of patients with epithelial ovarian cancers (EOCs) has remained poor despite extensive cytoreductive surgery, high dose chemotherapy, checkpoint blockades and immunotherapies effective in some other types of cancer. The pathobiology of EOC cancer stem cells (CSCs) is not well understood. Observations demonstrate that EOCs exhibit in vivo two distinct CSC types - perivascular diploid CSCs dividing asymmetrically with the help of the host suicidal CD8+ T cells, and haploid CSCs at the cancer abdominal surface originating from meiosis I cytokinesis of bulk surface cancer cells. The perivascular CSCs contribute to the cancer cell bulk and, via left ovary venous blood, can cause EOC liver metastases. Haploid CSCs released from the bulk cancer surface cause the common pelvic and abdominal EOC spread. Former elimination of the host antibodies blocking T cell effectors by intermittent doses of cyclophosphamide exhibiting significant immunomodulatory anticancer effects, facilitation of the immune system reactivity against alloantigens of cancer cells by blood transfusions, and augmentation of anticancer immunity by bacterial toxins, resulted during the subsequent treatment-free period into rejection of inoperable EOCs without any adverse events during the treatnment. To help prevent cancer relapses, patients treated for advanced primary epithelial cancers should be considered as candidates for continuously stimulating immune anticancer activity by treatments such as daily metformin and weekly lentinan consumptions.
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Gingival Stimulation: An Important Metabolic Regulator?

This study aimed to determine whether a relationship exists between gingival stimulation and the levels of leptin, ghrelin, insulin and glucose, which are important regulators of energy homeostasis. Blood samples for ghrelin, leptin, glucose and insulin were taken from 15 male volunteers (mean age 25.5±2.3 years; mean body mass index 24.4±2.79 kg/m2), who did not brush their teeth for one day, after a 12 h-long overnight fasting and before standard breakfast (0 min) and thereafter at 30, 60, 120 and 180 min after breakfast. After toothbrushing after dinner and after a 12 h-long overnight fasting, blood samples were taken again before standard breakfast (0 min) and then after at the same time points following tooth brushing.A significant reduction was found in the leptin levels measured at 0, 30, 60, 120 and 180 min after tooth brushing (p < 0.005). The ghrelin levels also declined at these time points but were significant at 0, 30 and 120 min (p < 0.05). Despite the reduced insulin levels at 120 and 180 min after tooth brushing (p < 0.05), no significant change was observed in the glucose levels.
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Nuts and Body Weight - An Overview

Since obesity and overweight became health issues, tree nuts became considered as unhealthy, due to their high fat content. Their high energy density has been pointed as a major factor in body weight gain.
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The Effect of Interleukin-6-Type Cytokines and Adiponectin on MAPK Activation in the Immortalized Human Chondrocyte C28/I2 Line and Normal Human Chondrocytes

The C28/I2 line of immortalized juvenile human chondrocytes was employed to determine the extent to which recombinant human (rh) interleukin-6 (rhIL-6), the interleukin-6-like cytokine, rh-oncostatin M, and the adipokine, rh-adiponectin, activated extracellularsignal regulated kinase (ERK1/2), p38α mitogen-activated protein kinase (p38α MAPK) and c-Jun-amino-terminal kinase (JNK).
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Toxic Effect of Titanium (Tio2) on Wistar Rat (Rattus Norvegicus) Injected by Intravenously

Titanium dioxide (TiO2) (<100 nm) has been widely used in the production of paints, paper, and plastics, as well as in food additives and colorants .It has been classified as biologically inert in both humans and animals. Here we studied the toxicity of TiO2 on Wister rat. Main exposure area of NPs is caudal vein of Wistar rat.
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Cholesterol Homeostasis Imbalance and Brain Functioning: Neurological Disorders and Behavioral Consequences

Cholesterol is an amphipathic sterol compound that exerts both structural and physiological tasks in the plasma membrane of all eukaryotic cells. The planar and rigid structure of this molecule regulates the fluidity of the phospholipid bilayer and its permeability to solutes and ions.
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New Adipocytokines

They are cytokines secreted by adipose tissue considered to be immunomodulating agents, however they can be more accurately put into the larger, growing list of adipose-derived hormones.
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Thoroughbred Race Horses Management: A Key Role of the Veterinarian

The veterinarian must confront many situations when working with thoroughbred horses in which he must solve and make decisions that lead to balance between the animal and trainer / owner of the horse, the above should be resolved in an ethical and professional manner.
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Editorial Board Members Related to homeostasis

Kam C. Yeung

Associate Professor
Department of Biochemistry & Cancer Biology
University of Toledo College of Medicine
United States

Jana Barlic-Dicen

Assistant Professor
Department of Cell Biology
University of Oklahoma Health Sciences Center
United States

Lan Zhou

Assistant Professor
Department of Pathology
Case Western Reserve University
United States

Tibor Harkany

Department of Medical Biochemistry & Biophysics
Karolinska Institute


Associate Professor
Department of Pharmacy
University of Naples Federico II


School of Life Science
University of Science and Technology

Andreu Palou

Laboratory of Molecular Biology, Nutrition and Biotechnology
University of the Balearic Islands
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