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Articles Related to immune

A Randomized Double-Blind Placebo Controlled Clinical Trial Evaluating the Effects of an Investigational Study Product on Exercise Induced Muscle Soreness, Markers of Inflammation, Muscle Damage and Exercise Performance in Healthy Males

Gherkin, a pure botanical extract from cucumber is a phytonutrient rich vegetable which may have been shown to have anti-inflammatory and pain relieving properties. The purpose of this randomized double-blind placebo study was to determine the effects of Gherkin (Cuvitus™, Actido®)on exercise performance, markers of inflammation and acute muscle soreness in healthy males.
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Former Effective Immunotherapy without Adverse Events of Inoperable Epithelial Ovarian Cancers and a Prospect for the Immune Prophylaxis

Current cancer treatments by immune checkpoint blockades are limited due to severe adverse events caused by alteration of the immune system required for homeostasis of normal tissues. Common cancer chemotherapy alters the quality of patients’ lives. Platinum-based treatment can lead to severe neurotoxicity with chronic debilitation. Additionally, survival of patients with epithelial ovarian cancers (EOCs) has remained poor despite extensive cytoreductive surgery, high dose chemotherapy, checkpoint blockades and immunotherapies effective in some other types of cancer. The pathobiology of EOC cancer stem cells (CSCs) is not well understood. Observations demonstrate that EOCs exhibit in vivo two distinct CSC types - perivascular diploid CSCs dividing asymmetrically with the help of the host suicidal CD8+ T cells, and haploid CSCs at the cancer abdominal surface originating from meiosis I cytokinesis of bulk surface cancer cells. The perivascular CSCs contribute to the cancer cell bulk and, via left ovary venous blood, can cause EOC liver metastases. Haploid CSCs released from the bulk cancer surface cause the common pelvic and abdominal EOC spread. Former elimination of the host antibodies blocking T cell effectors by intermittent doses of cyclophosphamide exhibiting significant immunomodulatory anticancer effects, facilitation of the immune system reactivity against alloantigens of cancer cells by blood transfusions, and augmentation of anticancer immunity by bacterial toxins, resulted during the subsequent treatment-free period into rejection of inoperable EOCs without any adverse events during the treatnment. To help prevent cancer relapses, patients treated for advanced primary epithelial cancers should be considered as candidates for continuously stimulating immune anticancer activity by treatments such as daily metformin and weekly lentinan consumptions.
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A Study of Immune Response in Nile Tilapia (Oreochromis niloticus) Fed Levamisole Incorporated Diet

This study was undertaken to evaluate the influence of levamisole on the immune enhancement of Nile tilapia (Oreochromis niloticus) against potential bacterial pathogens, Fish with weight of 98±5 g were randomly distributed into seven groups each at a rate of 20 fish per 300-L aquarium and fed on a diet containing 0.0, 250, 500, 750, 1000, 1250 or 1500 mg levamisole/kg diet for eight weeks.
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Immune Checkpoint and Ovarian Cancer

Many scientists and biotechnology companies had given up on the idea of cancer immunotherapy in 1990s. Almost a decade after first detection of T cell suppression effect of CTLA4 the identity of its antibody was established. While they are found effective in many cancers including melanoma, lung cancer etc. immune checkpoint inhibitors have lent an important measure to manage recurrent and refractory ovarian cancer. This subject needs constant updating specially for students of ovarian cancer who are looking at this avenue of cure with much hope.
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Sjögren’s Syndrome - Oral Changes, Advanced Diagnosis, and Management - A Case Report

Sjögren syndrome (SS) is chronic, systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands. It is an elaborate involvement of the lacrimal and salivary glands, which eventually lead to keratoconjunctivitis sicca and xerostomia.
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An Introduction to the Approaches of Novel Drug Delivery Systems for Acquired Immune Deficiency Syndrome (AIDS)

The currently available anti HIV agents have several drawbacks such as short half life, low bioavailability, poor CNS penetration and retention, hepatic first pass metabolism, undesirable side effects and frequent dosing regimen.
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Mesenchymal Stem Cells from Different Tissues: Immune Status and Activity

Mesenchymal stem cells (MSCs) have been found in almost all tissues and due to their regenerative properties represent promising tools in cell-based therapy. Role of MSCs in tissue repair is strongly governed by their interplay with immune cells and regulating factors.
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The Extracorporeal Bio-Xeno Perfusion (myelo-timo-spleen) in Multi-organ Supportive Therapy (MOST) as a Modulator of Energy, for Immuno Correction Compensatory Anti-Inflammatory Response Syndromes, and Persistent Inflammation, Immuno suppression, Catabolism, and Multi-organ Dysfunction

The use of bio-perfusion as active method of energo-modulation and suspension of PICS expansion, which depends on the elimination of hypo(an)ergic mitochondria performed through a lysosomal clearance (mitophagy) so as to maintain the eu-ergic mitochondria which are able to contribute to the formation of cell energy, and ultimately, to the whole body as macroergic system.
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Immunosenescence in Humans: Changes to the Aged T Lymphocyte Population in Response to Persistent Cytomegalovirus Infection

Immunosenescence describes the decrease in immune function with advancing age, a phenomenon that is associated with changes in the B and T lymphocyte populations. CD8+ T cells display the most dramatic phenotypical and functional changes within the T cell compartment whereby the cohorts of effector and memory T cells expand while the total population and diversity of naive T cells both decline.
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Anti-Inflammatory Effects of β-Glucan in Cancer Related Fatigue

Immune-mediated inflammatory diseases are among the exhausting diseases which are often difficult to diagnose. Fatigue is the most common syndrome accompanying cancer diseases and treatment. In cancer patients, fatigue is not only a manifestation of treatment, but also reflects biological effects of the tumor.
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AIDS Puzzle was Solved

Author discovered the main law of nature - the Law of World Harmony. Applying this law to the problem of AIDS, the author has solved the problem. AIDS, according to the author, is not infectious disease, but it is a disease of the “chain reaction” type.
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Immunodeficiency and Microbial Infections

Immunodeficiency refers to failure of immune system to encounter infections by different microbial pathogens such as fungi, bacteria, viruses and protozoan. This is called acquired or secondary immunodeficiency syndrome (SIS).
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AIDS: Signs to Management of the Disease

Acquired Immune Deficiency Syndrome (AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV). They get it after being infected with the HIV virus. HIV (human immunodeficiency virus) is a retrovirus that primarily infects components of the immune system.
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Guillain-Barr´E Syndrome with Bilateral Extensor Plantar Reflexes

Guillain-Barr´e syndrome (GBS) usually presents with lower motor neuron (LMN) symmetrical weakness, areflexia, and hypotonia. GBS has rarely been reported with up going plantars’ response. We report a case of GBS with up going plantars during the course of the disease.
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m6a RNA Methylation: The Implications for Health and Disease

The recent resurgence of interest in m6A has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification. The m6A modification is a highly reactive and fluid modification which can respond rapidly to a broad variety of stimuli, and translate these signals into cellular activity. The little information that has been established on its functional capacity has opened up many new avenues of research and has tremendous implications for several fields of study.
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Editorial Board Members Related to immune

Yinghao Wu

Assistant Professor
Department of Systems & Computational Biology
Yeshiva University
United States

Suresh G. Joshi

Associate Professor
Department of Microbiology and Immunology
Drexel University
United States

PAULA M. CHILTON

Assistant Professor
Department of Microbiology & Immunology
University of Louisville
United States

UDAI P. SINGH

Associate Professor
Department of Pathology, Microbiology and Immunology
University of South Carolina
United States

Shen Hu

Associate Professor
School of Dentistry
University of California at Los Angeles
United States

Noah Isakov

Professor
Department of Microbiology and Immunology and the Cancer Research Center
Ben Gurion University of the Negev
Israel

Jeffrey Michael Venstrom

Assistant Professor
Department of Medicine
University of California, San Francisco
United States

Azad Kumar Kaushik

Associate Professor
Department of Immunology
University of Guelph
Canada

KRZYSZTOF KOSTRO

Professor
Department of Epizootiology and Clinic of Infectious Diseases
Lublin University
Poland

Walter Royal

Professor
Department of Neurology
University of Maryland
United States
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