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Articles Related to inflammation

Review of the Diagnostic Value of Ultrasound Imaging in Giant Cell Arteritis

Giant cell arteritis (GCA) requires prompt diagnosis as clinical indicators of GCA are non-specific. Temporal artery biopsy (TAB) can be inconclusive and difficult to arrange timely. MR imaging is accurate for showing vessel thickening. However, the availability of MRI remains an issue in many radiology departments.
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Periodontal Maintenance Therapy and Generalized Aggressive Periodontitis: Brief Review of the Literature and Case Report

This case report presents an unusual variant of generalized aggressive periodontitis that was managed by nonsurgical therapy which included the use of a novel tooth gel. Also, a brief review of the literature is offered as context for this unusual clinical case. The patient, a 40-year old Caucasian female, presented with advanced bone loss involving all teeth, intense inflammation of the attached gingiva and little obvious supra- or subgingival biofilm and dental calculus. Presence of systemic disease, high levels of periodontal microbial pathogens and IL-1α and IL-1β polymorphisms were evaluated and all determined to be negative. Gingival biopsy resulted in a diagnosis of nonspecific inflammation. Treatment consisted of 2- and 3-month intervals for periodontal maintenance appointments and eventually the introduction of an activated edathamil-based tooth gel. Over the subsequent 4-years the patient’s periodontal status stabilized as manifested by no further loss of tooth supporting bone, a reduction in the percentage of periodontal pockets of 4-6 mm depth and a reduction in the percentage of sites exhibiting bleeding upon periodontal probing. The significance of this case report is to emphasize that, even in cases of severe generalized aggressive periodontitis, nonsurgical periodontal therapy can be effective. In addition, it appears that a novel tooth gel containing activated edathamil is effective at reducing gingival inflammation with a concomitant reduction in percent of sites that bleed on periodontal probing.
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The ACAI (Euterpe oleracea Mart.) Pulp Consumption Improves Blood Pressure Levels in Women with Higher Concentrations of Interferon-Gamma

Interferon-gamma (IFN-γ) is associated with the inflammatory responses modulation, which could culminate in chronic metabolic diseases. In this context, the aim of the present study was to evaluate the effect of the acai (Euterpe oleracea Mart. mart.) pulp consumption on the anthropometric, clinical and biochemical parameters in women clinically healthy, with IFN-γ, respectively, smaller and higher than 5 pg/mL. Twenty four women in G1 (with IFN-γ concentrations smaller than 5 pg/mL) and sixteen in G2 (with IFN-γ concentrations greater than 5 pg / mL), consumed 200g per day of acai pulp during four weeks. Anthropometric and body composition measurements, biochemical and clinical data were evaluated before and after the intervention
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Compartmentalization Modules of Inflammatory Response are Centered on the Epithelial-Mesenchymal Transition of Transforming Cells in Carcinogenesis

The epithelial-mesenchymal transition (EMT) event in carcinogenesis is dependent on multiple operant pathways of master transcription as proposed for NF-kappaB and in terms of the initiated progression of malignant transformation. Inflammation is a primarily compartmentalized series of distinct and overlapping systems that induce and enhance multifocal operabilities within both the nucleus and cytoplasm by systems of enhancer/inhibitory modes of modulation of multi-gene transcription.
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A Randomized Double-Blind Placebo Controlled Clinical Trial Evaluating the Effects of an Investigational Study Product on Exercise Induced Muscle Soreness, Markers of Inflammation, Muscle Damage and Exercise Performance in Healthy Males

Gherkin, a pure botanical extract from cucumber is a phytonutrient rich vegetable which may have been shown to have anti-inflammatory and pain relieving properties. The purpose of this randomized double-blind placebo study was to determine the effects of Gherkin (Cuvitus™, Actido®)on exercise performance, markers of inflammation and acute muscle soreness in healthy males.
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Changes in Several Disease Parameters Including Abzymes and Hematopoietic Progenitor Colony Formation in Brain Inflammation and Demyelination

Demyelination induced by cuprizone-is a widely used experimental model to analyze processes of re- and demyelination in the central nervous system (CNS). Here we used C57BL/6 mice; a model of experimental autoimmune encephalomyelitis (EAE) mimicking important aspects of human multiple sclerosis, to evaluate effects of cuprizone-dependent demyelination on different parameters associated with autoimmune inflammation. The treatment of mice with cuprizone leads to a significant decrease of several indexes characterizing spontaneous and myelin oligodendrocyte glycoprotein (MOG35-55)
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Jugular versus Mammary Vein Acid-Base Balance, Blood Gases, Hematobiochemical Profiles and Inflammation Biomarkers in Goats with Acute Mastitis

The objectives of this study was to investigate the acid-base balance, blood gases, hematobiochemical profiles and the inflammation biomarkers fibrinogen, serum amyloid A (SAA) and haptoglobin (Hp) in the mammary and jugular veins of goats with mastitis. Blood samples were collected from the jugular and mammary veins from 26 goats with mastitis and from 10 healthy lactating goats. In diseased goats, the affected quarter had a remarkable degree of swelling, hard and sore to touch; the milk was bloody. In the jugular vein of diseased goats, the values of PCO2, PO2, base excess (BE), HCO3 and TCO2 were significantly lower than in the jugular vein of controls.
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Clinical Utility of Triglyceride: HDL-Cholesterol Ratio as a Surrogate Marker of Inflammation in Pediatric Obesity

The prognostic utility of the triglyceride: HDL-cholesterol (TG:HDL-C) ratio, a marker for insulin resistance, is unknown among high-risk children and adolescents. We examined the clinical utility of TG:HDL-C ratio as a marker of insulin resistance and chronic inflammation in obese youth.
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Inguinal Lymph Node Squamous Cell Carcinoma of Unknown Primary Site: A Case Report

Carcinoma of unknown primary site (CUP) is a heterogeneous group of malignancies associated with dismal prognosis. Although majority of the patients present with disseminated disease, some of them do present with disease limited to the lymph nodes.
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Association between Delay in Surgical Treatment and Perforation in Acute Appendicitis

Acute appendicitis is a prevalent emergency surgical pathology and without prompt intervention may lead to gangrene, perforation and death. Increased mortality and morbidity will increase the hospital stay and the costs. We aimed to see the association between surgical treatment and perforation.
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The Extracorporeal Bio-Xeno Perfusion (myelo-timo-spleen) in Multi-organ Supportive Therapy (MOST) as a Modulator of Energy, for Immuno Correction Compensatory Anti-Inflammatory Response Syndromes, and Persistent Inflammation, Immuno suppression, Catabolism, and Multi-organ Dysfunction

The use of bio-perfusion as active method of energo-modulation and suspension of PICS expansion, which depends on the elimination of hypo(an)ergic mitochondria performed through a lysosomal clearance (mitophagy) so as to maintain the eu-ergic mitochondria which are able to contribute to the formation of cell energy, and ultimately, to the whole body as macroergic system.
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Randomized Study of the Effects of Statin on Inflammatory and Prothrombotic States in Obese Adolescents

Obesity is a major public health concern in many countries. In Europe 4.1% of the girls and 5.4% of the boys aged 10-12 years are obese according to the International Obesity Task Force criteria.
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Anti-Inflammatory Effects of β-Glucan in Cancer Related Fatigue

Immune-mediated inflammatory diseases are among the exhausting diseases which are often difficult to diagnose. Fatigue is the most common syndrome accompanying cancer diseases and treatment. In cancer patients, fatigue is not only a manifestation of treatment, but also reflects biological effects of the tumor.
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m6a RNA Methylation: The Implications for Health and Disease

The recent resurgence of interest in m6A has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification. The m6A modification is a highly reactive and fluid modification which can respond rapidly to a broad variety of stimuli, and translate these signals into cellular activity. The little information that has been established on its functional capacity has opened up many new avenues of research and has tremendous implications for several fields of study.
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Sarcoidosis - A Case of “Resistant Tuberculosis”

Sarcoidosis is a multisystem granulomatous disease of unknown aetiology. It usually has a benign course, but those cases with multi system involvement have poorer prognosis. Sarcoidosis is an under diagnosed disease in India, probably due to the close resemblance to tuberculosis and the lack of awareness. But this disease is not so rare in India, as previously thought.
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Editorial Board Members Related to inflammation

Rajiv Saini

Associate Professor
Department of Periodontology & Oral Implantology
Pravara Institute of Medical Sciences – Loni
India

Yi-Wen Liu

Professor
Department of M icrobiology, Immunology and Biopharmaceuticals
National Chiayi University
Taiwan

Parameswaran Ramakrishnan

Assistant Professor
Experimental Pathology
Case Western Reserve University
United States

Luis Ulloa

Associate Professor
Department of Surgery
Rutgers New Jersey Medical School
United States

UDAI P. SINGH

Associate Professor
Department of Pathology, Microbiology and Immunology
University of South Carolina
United States

Henrique Serezani

Assistant Professor
Department of Microbiology and Immunology
Indiana University
United States

Matthias Clauss

Associate Professor
Department of Medicine
Indiana University
United States

STEFAN KOSTADINOV

Assistant Professor
Alpert Medical School
Brown University
United States

Gang Chen

Professor
Jiangsu Key Laboratory of Neuroregeneration
Nantong University
China

Janet Liversidge

Professor
School of Medicine and Dentistry
University of Aberdeen Institute of Medical Sciences
United Kingdom
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