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Articles Related to insulin resistance

The Effects of Vitamin D on Obesity, Insulin Resistance and Type 2 Diabetes

Vitamin D is a fat-soluble vitamin. It is also referred to as a steroid hormone with an active form that can bind to receptors. The main way to obtain vitamin D is its synthetization on the skin with the effect of ultraviolet light. It is activated in the body by two hydroxylation reactions in the liver and kidneys. Vitamin D is said to have other effects besides those on the bone metabolism. Vitamin D deficiency is a global social health problem. It is associated with cardiovascular diseases, obesity, metabolic syndrome, type 2 diabetes, various types of cancer, immune deficiencies and increased mortality. It is frequently observed in obese individuals. A possible molecular mechanism of the relationship between obesity and vitamin D deficiency may be associated with the metabolism in mature adipocytes, oxidative stress, inflammation and the gene expression regulation capacity of vitamin D which is related to the adipogenesis process. Vitamin D may lead to an increase in insulin secretion and a decrease in insulin resistance by regulating the immune system. Inflammatory cytokine production is thought to be one of the mechanisms of action of vitamin D on insulin resistance. Inflammatory cytokines appear to be associated with obesity and insulin resistance. Low levels of vitamin D may cause disruption of insulin secretion. Vitamin D may be involved in β-cell secretion activity and changes in tissue response to insulin. There is a relationship between inadequate 25(OH)D levels and β-cell dysfunction. Vitamin D may have beneficial effects on β-cell function by suppressing the renin-angiotensin system. Based on all this information, it may be concluded that vitamin D is associated with obesity, insulin resistance and diabetes, and vitamin D deficiency may form the basis for these conditions.
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Clinical Utility of Triglyceride: HDL-Cholesterol Ratio as a Surrogate Marker of Inflammation in Pediatric Obesity

The prognostic utility of the triglyceride: HDL-cholesterol (TG:HDL-C) ratio, a marker for insulin resistance, is unknown among high-risk children and adolescents. We examined the clinical utility of TG:HDL-C ratio as a marker of insulin resistance and chronic inflammation in obese youth.
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How Should we Screen Overweight and Obese Adolescents for Risk of Type 2 Diabetes in Large Public Health Initiatives?

To develop a valid method to identify insulin resistance (IR) in overweight and obese adolescents without requiring a fasting blood sample.
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Hemodynamic and Autonomic Reactivity to Mental and Physical Stress in Lean, Overweight and Obese Subjects

There could be progressive changes in hemodynamic and autonomic parameters causing cardiovascular damage from lean to morbid obesity. We aim to study resting and reactivity of hemodynamic and autonomic parameters to physical and mental stress in lean, overweight and obese subjects of the Oman Family Study (OFS).
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Dietary Omega-3 Intakes in Southern African American and Southern Caucasian Women

Given the greater incidence and severity of obesity in Southern African American (SAAW) than Southern Caucasian women (SCW), it is important to determine factors contributing to this metabolic, racial disparity. Traditional Southern foods contribute to dietary patterns high in fat.
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Editorial Board Members Related to insulin resistance

VICTORIA J VIEIRA-POTTER

Assistant Professor
Department of Nutrition and Exercise Physiology
University of Missouri
United States

Andrey Budanov

Assistant Professor
Department of Human and Molecular Genetics
Massey Cancer Center
United States

Solomon Ike Okosun

Associate Professor
Department of Population Health Sciences
School of Public Health
Georgia State University
USA

ASISH K. SAHA

Associate Professor
Department of Medicine
Boston University
United States

Liqing Yu

Associate Professor
Departments of Animal and Avian Sciences
University of Maryland
United States
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