Articles Related to interleukins
Asthma is a common chronic airway disease affecting about 334 million people worldwide, and an estimated 7 million children globally. Approximately 10% of patients with asthma have severe refractory disease, which is uncontrolled despite using high doses of inhaled corticosteroids and other modifiers. Among these patients are patients with eosinophilic asthma. Eosinophilic asthma is a phenotype of asthma that is usually very severe and persistent, with frequent exacerbations. It is characterized by the presence of high levels of eosinophils, and CD+4 Th2 cells in the lungs and airways. Eosinophils play a pivotal role in the pathogenesis and severity of asthma. Most patients with eosinophilic asthma respond to the classic stepwise guided treatment. However, 50% of patients with eosinophilic asthma are refractory to corticosteroids and long-acting β2-agonists. Currently, there are targeted personalized biologics for these patients. These biotherapeutics include IgE, interleukin and interleukin receptor monoclonal antibodies,they have added advantageous steroid-sparing effects.
The veterinarian must confront many situations when working with thoroughbred horses in which he must solve and make decisions that lead to balance between the animal and trainer / owner of the horse, the above should be resolved in an ethical and professional manner.