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Articles Related to leukemia

Degree of Malignancy of T-Cell Acute Lymphocytic Leukemia Related to Autofluorescence in an EL4-Based Model

T cell acute lymphocytic leukemia (T-ALL) is an aggressive hematologic malignancy in terms of its pathology and populations. It is important to understand the phenomenon of autofluorescence in living cells because normal and cancer cells can be distinguished by this feature. However, the autofluorescence link to T-ALL is poorly understood.
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How to select Tyrosine Kinase Inhibitor for the patients with newly diagnosed Chronic Myeloid Leukemia?

The clinical outcomes of chronic myeloid leukemia (CML) have been improved by tyrosine kinase inhibitors (TKIs). However, there is no established consensus for TKI selection in de novo CML. We investigated TKI treatment patterns in a real-world setting. Among 95 chronic-phase CML patients, 44% were initiated treatment with imatinib, 26% with dasatinib, and 30% with nilotinib. Our data suggest that imatinib remains applicable and that dasatinib has a favorable therapeutic effect, although pleural effusion can arise. Nilotinib was the most prevalent TKI as the treatment-associated adverse events were deemed more manageable than those associated with imatinib and dasatinib.
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Tomotherapy Treatment of Chronic Lymphocytic Leukemia and Ocular Lymphoma

A sixty-five-years-old male patient with history of non-Hodgkin’s lymphoma of the right orbit and a fifty-years-old female patient with chronic lymphocytic leukemia with peripheral lymphocytosis were treated on TomoTherapy. In the first case, a 1 cm beam was used for planning a delivery of 30.6 Gy in 17 fractions with a sequential boost of 9 Gy in 5 fractions. Tumor involvement of the ipsilateral lens and lacrimal gland in the planning target volume necessitated a compromise between preserving patient’s vision and delivery of tumoricidal dose to the target. In the second case, 30 Gy in 20 fractions delivery was planned with a 2.5 cm beam. The tumor extended anteriorly and this technique allowed sparing more orbital tissue and required a high modulation factor.
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Prevalence of the different FAB sub type of Acute Myeloid Leukemia related to hematological parameters in Sudanese

Acute myeloid leukemia (AML) is a heterogeneous disease. Therefore, various parameters are needed to classify this disease into subtypes. The commonly used method for diagnosis and classification is based on FAB criteria using morphology and cytochemical stains. For some of the categories, immunopheno typing is necessary. The aim of present study is to determine the frequency of various sub-types in acute myeloid leukemia using FAB criteria in our Sudanese population. This will aid in the correct diagnosis of acute leukemia and hence proper management of the patients.
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Acute Myeloid Leukemia Mimicking as Acute Megakaryoblastic Leukemia

Down syndrome or constitutional trisomy 21 was linked to leukemia for the first time in a case report published in 1930 since then, down syndrome has been recognized as one of the most important leukemia – predisposing syndromes and patients with down syndrome and leukemia have unique clinical features and significant differences in treatment response toxicity profiles compared to patients without down syndrome.
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Responses and Survival under Pegylated Interferon α2a Treatment for Patients with Post-MPN Acute Myeloid Leukemia and Acute Panmyelosis with Myelofibrosis

We report here for the first time the efficacy of pegylated interferon α2a (Peg-Ifn) as a therapy for patients with myelofibrosis and high blast counts. We treated four patients who were in an accelerated phase of myeloproliferative neoplasms or acute panmyelosis with myelofibrosis using only this drug.
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Observations on Aeromonas Infection in 7 Patients with Acute Leukemia

Aeromonas infections in humans are becoming increasingly frequent. They have the potential to infect humans and are associated with a variety of illnesses, such as enterocolitis, septicemia, skin and soft tissue infectious and peritonitis.
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Microwave and Magnetic (M2 ) Proteomics of Childhood B-ALL

We hypothesized that quantitative tandem mass spectrometry-based proteomics, incorporating rapid microwave and magnetic sample preparation (M2 proteomics), might enable relative protein expression to be correlated to childhood B-precursor acute lymphoblastic leukemia (B-ALL) cytogenetic subtypes, corresponding to low-risk (ETV6-RUNX1) and high-risk (MLL-R) subtypes.
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Vasculitis Associated with Chronic Lymphocytic Leukemia

A patient is present who has chronic lymphocytic leukemia (CLL) and developed a vasculitis involving the skin and large vessels along with immune complex mediated glomerulosclerosis. Both vasculitis and immune complex nephritis are rare manifestations of CLL.
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Development of the Analytical Model for the Assessment of the Efficiencies of Different Therapeutic Modalities in Leukemia

Different therapeutic regimes like chemotherapy, cytokine based immunotherapy and/or stem cell transplantation are generally be the suggested options for treatment of leukemia. However, the selection of the best therapeutic strategy for an individual patient remains uncertain till now
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The Emergence of Multiple Myeloma in a Patient with Essential Thrombocythemia: A Case Report

Multiple myeloma is a neoplastic disease characterized by neoplastic proliferation of plasma cells and monoclonal protein expression and related tissue damage.In the presence of overt clinical signs, the disease can easily be diagnosed, however in order to diagnose atypical cases, further investigation is needed with high clinical suspicion.
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m6a RNA Methylation: The Implications for Health and Disease

The recent resurgence of interest in m6A has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification. The m6A modification is a highly reactive and fluid modification which can respond rapidly to a broad variety of stimuli, and translate these signals into cellular activity. The little information that has been established on its functional capacity has opened up many new avenues of research and has tremendous implications for several fields of study.
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Molecular Mechanisms of Mismatch Repair Genes in Cancer – A Brief Review

The DNA mismatch repair (MMR) system is necessary for the maintenance of genomic stability. The MMR system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops (IDLs) and heterologies generated during DNA replication and recombination.
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Unusual Presentation of CML in Pregnancy

Leukemia during pregnancy is rare, posing a complex series of questions, including appropriate therapy and maternalcounseling. Management of chronic myelocytic leukemia (CML) during pregnancy is limited.
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Unexplained severe lactic acidosis in emergency medicine

Case report A 49-year-old previously healthy man was admitted to the ICU after cardiac arrest following a short history with headache, blurred speech and reduced consciousness. After cardiopulmonary resuscitation perfusion rythm was regained, but the patient didn`t regain consciousness.
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Editorial Board Members Related to leukemia

Yun Dai

Associate Professor
Department of Medicine
Virginia Commonwealth University
United States

Elena Kolomietz

Assistant Professor
Department of Pathology and Lab Medicine
University of Toronto
Canada

Dan Douer

Leukemia Service
Memorial Sloan Kettering Cancer Center
New York
United States

Martin Falk

Head and Professor
Institute of Biophysics of ASCR
Czech Republic

Francesco Passamonti

Professor of Hematology
University Hospital Ospedale di Circolo
Fondazione Macchi, Varese
Italy

PREET M. CHAUDHARY

Professor
Department of Medicine
University of Southern California
United States

SAN MING WANG

Associate Professor
Department of Genomics
University of Nebraska Medical Center
United States

Jeffrey Michael Venstrom

Assistant Professor
Department of Medicine
University of California, San Francisco
United States

David J. MacEwan

Professor
Department of Molecular & Clinical Pharmacology
Institute of Translational Medicine
University of Liverpool
United Kingdom

Rammurti T. Kamble

Professor of Medicine
Baylor College of Medicine
United States
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