Articles Related to liver

The transdermal drug delivery system is technique that provides drug through the intact skin. Skin penetration enhancement techniques have been developed to increase the bioavailability of drug substance. These review describes various transdermal patches available in market, types of patches, basic components, polymer used in formulation. The novel drug delivery method do well and complete with those already on the market the main problem that requires consideration include device design and safety, efficacy, ease of handling and economical. Transdermal drug delivery system represent the most attractive method among these because of its low rejection rate, magnificent, ease of administration and better convenience and compliance with patient. This review article provide an overview of transdermal drug delivery system contains various innovative dosage forms. In comparison transdermal patch are effective due to its easy to apply and non-invasive.

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Background: Manifold emulsions are used to increase the bioavailability of active medicinal ingredients and to provide a longer drug delivery mechanism. Hydrophobic and hydrophilic combinational surfactants are frequently used to stabilize the manifold emulsions.

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The term mucoadhesion can be defined as a phenomenon of interfacial molecular attractive forces in the layer of surface of a biological membrane and the natural or synthetic polymer, which allows the polymer to the adhere the surface of that membrane for an extended as well prolonged period of time. Since the last four decades, the conception of mucoadhesion has achieved a important precious interest in the various fields of pharmaceutics

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E-cigarettes (ECs) can affect several organs in the body. On the liver, it causes toxic and immunological effects associated with many inflammatory processes and oxidative stress. E-cigarettes may cause hepatic fibrosis, steatosis, cell dysfunction, injury with the elevation of liver enzymes, and cancer. On the other hand, it also causes hepatic DNA damage and mitochondrial dysfunction. Nicotine affects both cellular and humoral immune responses.

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Forty patients with CHDs who received liver biopsy to stage fibrosis and 12 normal subjects performed also shear wave elastography (SWE) and ELF-test. We chose two different outcomes for histological fibrosis (F0-F1 vs F2-F4) and (F0-F2 vs F3-F4). ELF-test and SWE were independent predictors, categorized using ROC analysis. Two scores called SCORE1 and SCORE2 were devised.

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To adapt the perfusion-CT (PCT) examination-protocol in patients with liver cirrhosis and suspected hepatocellular carcinoma (HCC) while keeping diagnostic accuracy and qualitative assessment of tumor enhancement patterns (wash-in/wash-out) at comparable radiation dose.

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: Colporrhexis is separation of vaginal fornix from cervix and is a rare but serious cause of major obstetric haemorrhage in women during labor. Immediate clinical diagnosis is difficult but must be anticipated if haemorrhage continues despite contracted uterus following delivery. Rapid resuscitation and decision of laparotomy with either repair or hysterectomy is key in preventing maternal mortality.

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The delivery of the drug at a predetermined controlled rate and its systemic effect is utmost important. Topically administered medicaments in the form of patches is being popular for its effectiveness. The main objective of this research was to formulate matrix-moderated transdermal patch of diclofenac potassium and to evaluate them concerning various in-vitro parameters.

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The aim of the present work was formulation and evaluation of in-situ gelling system of Ciprofloxacin Hydrochloride. The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solution due to rapid precorneal elimination of the drug may be overcomed by the use of in-situ gel forming system that are installed as drop into the eye and undergo sol to gel transition in the cul-de-sac.

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Various complementary approaches have been used against multiple organ dysfunction syndrome (MODS), which is the major contributor in high mortality among the healthcare centers.

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Vitamin A has multitude of function and liver plays pivotal role in its metabolism. Diseases of liver of various etiology and severity may affect vitamin A status.

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The rise in cesarean delivery has higher maternal risks for the current and subsequent pregnancies. It is associated with short and long term complication as any surgical procedure. As prevalence of Cesarean section increased beyond reminded range without concomitant decrease in maternal and neonatal mortality and morbidity rates significant concern that C/S is over used once women has had one birth by Ceserean section.

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Dermatopathic lymphadenitis (DL) is considered a benign disease, the symptoms of which can be relieved with only anti–histamine. It can be confused with lymphoma. Here, we report a case of DL, which resulted in hemophagocytic lymphohistiocytosis (HLH). After adequate treatment, remission was obtained at first; however, recurrence with liver failure occurred six months later, which quickly resulted in death. This particular case has not been reported elsewhere. It reminds us that even benign dermatological problems can cause life–threatening syndromes, such as, in this case, HLH. The risk needs to be taken seriously in patients presenting with fever, skin problems, and lymphadenopathy.

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Ectopic liver tissue is an uncommon finding and may be found in multiple abdominal sites, most commonly on the gall bladder. It is usually asymptomatic and is discovered incidentally during cholecystectomy, but there are potential complications. We present a case of an ectopic liver seen on the gallbladder serosa during laparoscopic cholecystectomy being performed for symptomatic cholelithiasis, and briefly review the literature.

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