Articles Related to lymphocyte

There is a need to develop a universal vaccine that can boost immunity to coronaviruses if some modifications in their structure occur. This is what we are dealing with nowadays: a virus that can mutate its structure, while immunity is standing still in facing the virus. We report on preclinical trials of CRCx 3 and CRCx 2 vaccine candidates in inducing an elevated level of positive neutralizing antibodies as well as a cellular immune response in an animal model to provide protection against SARS-CoV-2. Highly efficient protection against SARS-CoV-2 was obtained with three-dose immunization using 0.25 ml of CRCx vaccine with a 25-mm needle at 7-day intervals between successive injections. In addition, CRCx vaccine candidates exhibit efficient productivity and good genetic stability for vaccine manufacture. These results support the further evaluation of CRCx in a clinical trial.

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Evaluation of peripheral blood morphology is an important screening tool for many diseases.

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Male Wistar rats were treated daily and intraperitoneally with CdS-Dextrin nanoparticles (100 μg/kg) during 30, 60, and 90 days. The effect of subacute and chronic administration of CdS-Dextrin nanoparticles on CD4/CD8 subpopulations of thymocytes, spleen-derived T cells, and peripheral blood CD4/CD8/CD3 T cells were analyzed by flow cytometer using a Rat T Lymphocyte Cocktail. An indirect ELISA kit analyzed cytokine Th1/Th2 levels. A DNA content and cell cycle analysis was carried out in bone marrow cells by flow cytometry. We also analyzed the presence of CdS-Dextrin nanoparticles in the thymus and spleen.

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Homocysteine is a parameter that plays an important role for diagnosing several diseases mainly cardiovascular diseases. In this study, the first time reference values for homocysteine levels detected in healthy Golden Retriever, Terrier, German Shepherd and Labrador Retriever breeds of dogs play an important role in the prognosis of many diseases.

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Immunosenescence describes the decrease in immune function with advancing age, a phenomenon that is associated with changes in the B and T lymphocyte populations. CD8+ T cells display the most dramatic phenotypical and functional changes within the T cell compartment whereby the cohorts of effector and memory T cells expand while the total population and diversity of naive T cells both decline.

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Immunodeficiency refers to failure of immune system to encounter infections by different microbial pathogens such as fungi, bacteria, viruses and protozoan. This is called acquired or secondary immunodeficiency syndrome (SIS).

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Ovarian cancer constitutes the second most common gynecological cancer with a five-year survival rate of 40%. Among the various histotypes associated with hereditary ovarian cancer, high-grade serous epithelial ovarian carcinoma (HGSEOC) is the most predominant and women with inherited mutations in BRCA1 have a lifetime risk of 40-60%. HGSEOC is a challenge for clinical oncologists, due to late presentation of patient, diagnosis and high rate of relapse. Ovarian tumors have a wide range of clinical presentations including development of ascites as a result of deregulated endothelial function thereby causing increased vascular permeability of peritoneal vessels.

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The recent resurgence of interest in m6A has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification. The m6A modification is a highly reactive and fluid modification which can respond rapidly to a broad variety of stimuli, and translate these signals into cellular activity. The little information that has been established on its functional capacity has opened up many new avenues of research and has tremendous implications for several fields of study.

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The amyloid precursor protein (APP) is mainly known for being the precursor of the ß-amyloid peptide, which accumulates in plaques found in the brain of Alzheimer’s disease patients. Expression in different tissues and the degree of sequence identity among mammals indicate an essential and non-tissue specific physiological function.

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Feline lower urinary tract disease (FLUTD) is a supposed to a life threatening condition in cats, especially in males (Toms), when obstructive. Early diagnosis and treatment is necessary otherwise it may lead to death. Condition appears with stranguria, pollakiuria, dysuria and sometime in severe conditions hematuria and anuria may be present. Similar five cases of age ranging from 3-6 years, with common history of commercial feed and indoor placement were examined during the course of 3 month. Firstly clinical evaluation including clinical parameters and physical manipulation was done followed by laboratory tests. Complete blood count (CBC) didn’t give any significant change but urinalysis results were quite doubtful with high values of specific gravity (SP), pH, erythrocyte, bacterial and leukocyte count.

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Mycophenolic Acid (MPA) is one of the most widely used immunosuppressive agents in kidney transplantation. This study was designed to compare the safety, tolerability and efficacy of two formulations of mycophenolic acid, Mycophenolate Mofetil (MMF) and Enteric-Coated Mycophenolate Sodium (EC-MPS), in renal transplant recipients.

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