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Articles Related to mL

Consistent Confidence Limits, P Values, and Power of the Non-Conservative, Size – α Modified Fisher exact Test

The classical Fisher exact test [1], which is unconditionally the uniformly most powerful unbiased (UMPU) test, requires randomization at the critical value(s) to be of size α. Obviously, one needs a non-randomized version of this. Rejecting the null only if the test-statistic’s outcome is more extreme than the critical values, reduces the actual size considerably. The modified Fisher exact test introduced in [2] additionally rejects the null when the test attains the critical value c(t) and the randomization probability γ(t) (that depend on the total number of successes T) exceeds a threshold γ0, which is determined such that, for all values of the nuisance parameter, the size of the unconditional modified test is smaller, but as close as possible to α. This greatly improves the size and power of the test as compared to, for example, the conservative nonrandomized Fisher exact test, while controlling the Type 1 error rate.
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Auditory Evoked Potentials as Yardstick for Tinnitus

: Aiming to evaluate the recent theoretical postulates on tinnitus underscoring the role of thalamocortical neural tracts, the present study 1) explores Middle Latency Response (MLR) as a possible physiological measure of tinnitus: thus investigates the predicted exaggeration of Pa-Na, Na-Pb interpeak amplitudes in tinnitus patients and 2) explores MLR as a prognostic indicator of Tinnitus Retraining Therapy: thus evaluates possible decrease in Pa-Na & Na-Pb amplitude after 2weeks exposure to Tinnitus Retraining Therapy.
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Primary Adenoid Cystic Carcinoma of the Mandibular Bone, an Extremly Rare Case Report

Adenoid cystic carcinoma (ACC) is a rare epithelial neoplasm, that may affect the salivary glands. It comprises 30% of epithelial minor salivary gland tumors. We present the case of a 56-year-old non-smoking woman with no significant medical history. The MRI finds a lesional process involving the right hemi mandible, the right buccal floor, which extends towards the region of the masticators and infiltrates the submandibular gland. A bone biopsy of the mandible under general anesthesia was performed, showing an adenoid cystic carcinoma. After announcing the diagnosis to the patient, she refused any treatment
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Relative Efficiency of Different Sire Procedures in Crossbred Cattle

The records of 1198 crossbred cattle sired by 68 bulls were analyzed to estimate breeding values of sires using animal model Restricted Maximum Likelihood (REML), best linear unbiased prediction (BLUP), least squares methods (LSM) and simple daughter average ( D ) sire evaluation methods. The error variance of breeding values of sires were estimated and used in computing the relative efficiency of different sire evaluation methods. In the present study the least squares methods (LSM) have the lower error variance for Age at First Calving (AFC), First lactation milk yield (FLMY) and Lifetime lactation length (LTLL), while (BLUP) methods have the lower error variance for First lactation period (FLP), First dry period (FDP), First calving interval (FCI), First service period (FSP) and Lifetime milk yield (TLMY) as compared to other methods and accordingly, it was adjudged the most efficient sire evaluation method. In the present study, the higher value of coefficient of variation showing, there was very large variation in the herd for most of the traits under study. It indicated that the BLUP method is the best over the other three methods because estimated value of relative efficiency by BLUP method had smaller values than that of the other three methods. On the basis of the error variances of breeding values of sires the BLUP method was found most efficient sire evaluation method.
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Benign Pulmonary Metastasizing Leiomyoma

Benign metastasizing leiomyoma (BML) is a rare event that occurs in middle aged women with a history of uterine myomas. It is characterized by multiple leiomyomatous lesions in many tissues and organs, especially in the lungs. We report the case of 56 years old woman presenting chronic cough, hemoptysis and having a history of myomectomy for a uterine leiomyoma 6 years ago. Chest CT showed a right pulmonary process. The histological diagnosis was defined by bronchoscopy and biopsies. The surgery was not an option because of the bronchovascular extension of the tumor, so hormonal therapy was administrated to the patient. One year later, Chest CT showed that the tumor doesn’t increase.
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Prevalence of the different FAB sub type of Acute Myeloid Leukemia related to hematological parameters in Sudanese

Acute myeloid leukemia (AML) is a heterogeneous disease. Therefore, various parameters are needed to classify this disease into subtypes. The commonly used method for diagnosis and classification is based on FAB criteria using morphology and cytochemical stains. For some of the categories, immunopheno typing is necessary. The aim of present study is to determine the frequency of various sub-types in acute myeloid leukemia using FAB criteria in our Sudanese population. This will aid in the correct diagnosis of acute leukemia and hence proper management of the patients.
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Gross and Histopathological Alterations in Experimental Trypanosoma Evansi Infection in Donkeys and the Effect of Isometamidium Chloride Treatment

Trypanosoma evansi (T. evansi) infection causes wasting and fatal animal trypanosomosis. This study was aimed at determining the gross and histopathological alterations in donkeys experimentally infected with T. evansi and the effect of isometamidium chloride treatment. Apparently healthy donkeys (N=18) of mixed sexes were randomly assigned to 3 groups; A1 (Infected-untreated), A2 (Infected, isometamidium-treated) and B (Uninfected, control) of six animals each. Each animal in infected groups had about 2.0x106 T. evansi injected through the jugular vein. Parasitaemia levels were evaluated using HCT and Mice Inoculation Test (support test). Gross and histopathological examinations were also conducted post-infection and post-treatment.
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Acute Myeloid Leukemia Mimicking as Acute Megakaryoblastic Leukemia

Down syndrome or constitutional trisomy 21 was linked to leukemia for the first time in a case report published in 1930 since then, down syndrome has been recognized as one of the most important leukemia – predisposing syndromes and patients with down syndrome and leukemia have unique clinical features and significant differences in treatment response toxicity profiles compared to patients without down syndrome.
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Responses and Survival under Pegylated Interferon α2a Treatment for Patients with Post-MPN Acute Myeloid Leukemia and Acute Panmyelosis with Myelofibrosis

We report here for the first time the efficacy of pegylated interferon α2a (Peg-Ifn) as a therapy for patients with myelofibrosis and high blast counts. We treated four patients who were in an accelerated phase of myeloproliferative neoplasms or acute panmyelosis with myelofibrosis using only this drug.
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Costimulatory Molecules CD80 and CD86 Colocalized in Neutrophil Extracellular Traps (NETs)

Neutrophil extracellular traps (NETs) have been proposed as vehicles for the sensitization of T cells by decreasing their activation threshold.
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Molecular Mechanisms of Mismatch Repair Genes in Cancer – A Brief Review

The DNA mismatch repair (MMR) system is necessary for the maintenance of genomic stability. The MMR system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops (IDLs) and heterologies generated during DNA replication and recombination.
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Cholesterol Homeostasis Imbalance and Brain Functioning: Neurological Disorders and Behavioral Consequences

Cholesterol is an amphipathic sterol compound that exerts both structural and physiological tasks in the plasma membrane of all eukaryotic cells. The planar and rigid structure of this molecule regulates the fluidity of the phospholipid bilayer and its permeability to solutes and ions.
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Unusual Presentation of CML in Pregnancy

Leukemia during pregnancy is rare, posing a complex series of questions, including appropriate therapy and maternalcounseling. Management of chronic myelocytic leukemia (CML) during pregnancy is limited.
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Does Physical Activity and Sport Practice Lead to a Healthier Lifestyle and Eating Habits in Male Adolescents?

The prevalence of childhood obesity has been increasing rapidly and there is general consensus that good nutritional practices and physical activity should be encouraged as early as possible in life. The aim of this study was to describe and to compare the current lifestyle and dietary pattern of normal weight (NW) and overweight + obese (OW+OB) male adolescents who are physically active.
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Reduction of Bitterness and Enhancing Palatability of Cetirizine Oral Liquid Dosage Forms by Cyclodextrins

The aim of this manuscript is to study cyclodextrins (CDs) as a potential excipient to suppress bitterness and enhance palatability of pediatric liquid preparations for Cetirizine, an extremely bitter drug. Natural α, β and γ CDs; and β CD derivatives such as hydroxyl propyl (HP), randomly methylated (RM) and sulfobutyl ether (SBE) β-CDs were screened in different molar ratios of 1:1, 1:2 and 1:3 for their inhibition of the extremely bitter taste of Cetirizine using the human gustatory sensation test.
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Editorial Board Members Related to mL

Zeliha Selamoglu

Department of Medical Biology
Faculty of Medicine
Nigde Ömer Halisdemir University
Turkey

Zeliha Selamoglu

Professor
Department of Medical Biology
Faculty of Medicine
Nigde Ömer Halisdemir University Campus
Turkey

Ana Rita Ramalho Figueiras

Faculty of Pharmacy
University of Coimbra
Portugal

Daniel Lacorazza

Associate Professor
Departments of Pathology and Immunology
Baylor College of Medicine
United States

Hasan Sarptaş

Assistant Professor
Ege University Solar Energy Institute
Turkey

Josep Bassaganya-Riera

Professor
Virginia Bioinformatics Institute
United States

Markus Müschen

Professor
Department of Laboratory Medicine
University of California, San Francisco
United States

Eva Mischak-Weissinger

Professor
Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation
Hannover Medical School
Germany

Elmar J Prenner

Assistant Professor
Department of Biological Sciences
University of Calgary
Canada

Hülya Akgün

Professor
Faculty of Pharmacy
Department of Pharmaceutical Chemistry
Yeditepe University
Turkey
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