Articles Related to matrix

The transdermal drug delivery system is technique that provides drug through the intact skin. Skin penetration enhancement techniques have been developed to increase the bioavailability of drug substance. These review describes various transdermal patches available in market, types of patches, basic components, polymer used in formulation. The novel drug delivery method do well and complete with those already on the market the main problem that requires consideration include device design and safety, efficacy, ease of handling and economical. Transdermal drug delivery system represent the most attractive method among these because of its low rejection rate, magnificent, ease of administration and better convenience and compliance with patient. This review article provide an overview of transdermal drug delivery system contains various innovative dosage forms. In comparison transdermal patch are effective due to its easy to apply and non-invasive.

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Here we present a case of a 36–year–old woman who suffered from severe (118°) flexion deformity of the right wrist joint because of heavily burn scar contracture of the right hand wrist. After scar excision, the wrist external fixator was applied and adjusted regularly to extent the wrist and to obtain normal range of motion of the wrist joint. Skin reconstruction was performed with a dermal regeneration matrix and eventually with a split-thickness skin graf

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Pilomatrixoma is a rare benign skin tumor originating from the matrix of hair follicle cells. Pilomatrixoma is also known as, Malharbe’s calcific epithelium or pilotircoma [1]. Pilomatrixoma generally has benign characteristic properties.

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In today’s crime investigation world determination of ABO blood grouping is still a very vital and effective precess in the field of forensic crime scenes. This investigation involves the identification of blood group, on the clothes (Accuse, Victim, injured, Complainer) collected from the scene of crime, and its cross comparision with the blood sample send by medical officer. Hence for this purpose total of 200 cases were included in the study having the samples of blood of accuse, victim, injured, complainer consisting of male and female... The determination of ABO/Rh factor was performed by conventional tube method and matrix gel card. The comparison of both techniques shows a very comparative result. As the red blood cells are sensitized with antibody will get agglutinate in the presence of anti human reagent in the matrix gel card and this will be trapped in the gel column this helps for easy analysis of blood group. However spin tube method is an operator-dependent assay, and is more susceptible to handling errors, the results are not more objective. The matrix gel card method requires Small sample volumes, and gives standardized performance with technical ease, and is with ready automation, and increased biosafety; all these factors have made this technology advantageous. In both techniques the reaction strength for ABO grouping and Rh factor is mainly govern by agglutination reaction intensity between red blood cells and anti-human reagent.

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Application of matrix-metalloproteinases (MMP) inhibitors such as chlorhexidine (CHX) is capable of reducing bond strength loss over time by preventing collagen fibrils degradation.

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In the analysis of competing risks data, it is common that the exact cause of failure for certain study subjects is missing. This problem of missing failure type may be due to inadequacy in the diagnostic mechanism or reluctance to report the exact cause of failure.

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Fish oils are the most common source of omega-3 polyunsaturated fatty acids (n-3 PUFAs), mainly eicosapentaenoic acid (EPA). It has been pointed out protective effects and beneficial effects of EPA on body weight reduction, heart health, blood lipid profile, cardiovascular diseases and other diseases. Based on its biological activities, EPA may be developed to a complementary and alternative medicine through further research. In this paper, the pharmacological effects of EPA were summarized by reviewing the recent related literatures.

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In China, the scorpion Buthus martensii Karsch is used as functional food and medicinal materials. The scorpion, scorpion venoms and their extracts are effective in treating a variety of nervous system diseases such as epilepsy, apoplexy pains and facial paralysis.

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The present investigation was undertaken to evaluate the therapeutic efficacy and safety of Crominex 3+ (a complex of trivalent chromium, Phyllanthus emblica (Amla) extract and purified Shilajit) in moderately arthritic dogs.

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The objective of this investigation was to evaluate the efficacy and safety of purified Shilajit in moderately arthritic dogs. Ten client-owned dogs in a randomized double-blinded study received either a placebo or Shilajit (500 mg) twice daily for a period of five months. Dogs were evaluated each month for physical condition (body weight, body temperature, heart rate, and respiration rate) and pain associated with arthritis (overall pain, pain from limb manipulation, and pain after physical exertion).

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Researchers have been inventing new drugs since time immemorial. Of late it is established that the development of new drugs alone is not sufficient to ensure progress in drug therapy. The missing link is a potential strategy.It involves the apt selection of drug carrier systems.

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An Ultra-High Pressure Liquid Chromatography Time-of-Flight Mass Spectrometry (UHPLC-TOF-MS) method for quantitative analysis of 30 drugs in whole blood was developed and validated. The method was used for screening and quantification of common drugs and drugs of abuse in whole blood received from autopsy cases and living persons.

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A reliable, fast, sensitive and selective Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) method has been developed and validated for the determination of fenofibrate in marketed product (Lipanthyl) and human plasma. The chromatographic separation was performed on a reversed-phase Acquity®BEH C18 column (1.7 μm particle size, 50 mm x 2.1 mm ID) with an isocratic elution profile and mobile phase consisting of methanol and water (80:20, %, v/v). To achieve optimum chromatographic condition the influence of mobile phase composition and flow rate was investigated. The total chromatographic analysis time was as short as 2 min.

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