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Articles Related to necrosis

Osteo-Articular Complications in a Pediatric Sickle Cell Disease Population - Imaging Value

Sickle cell disease (SCD) is the most frequent of a group of conditions known as haemoglobinopathies. The disease is an autosomal recessive genetic disorder, characterized by abnormal haemoglobin (Hemoglobin S) that under certain conditions polymerizes resulting in microvascular occlusions. This pictorial review illustrates the osteo-articular manifestations associated with sickle-cell disease encountered in children in our institution with at least one Haematology appointment in 2013/2014. Osteo-articular manifestations with imaging findings were reported in 28 out of 97 patients. The most frequent complications and those that required hospital care were painful vaso-occlusive crisis and femoral head osteomyelitis.
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Acute Necrotizing Pancreatitis with Gastric Necrosis in a Female with Cerebral Palsy

The coexistence of drug -induced pancreatitis and gastric necrosis is very rare. Many drugs have been associated with pancreatitis and among the antiepileptic drugs; valproic acid has been commonly implicated.
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Effects of Age and Sex on Sickle Cell Disease Avascular Necrosis

Sickle cell disease (SCD) is a hemoglobinopathy. Based on genotypes, it is classified into sickle cell thalassemia (SCTh) and sickle cell anemia (SCA).
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Anterior Mediastinal Pseudo-Tumor Tuberculosis: Should We Settle for This Diagnosis?

Mr M.Y., 32 years old, presented since 5 months Dyspnea associated with a productive cough, in a context of night sweats and encrypted weight loss 5 kg in 3 months and who has consulted in a different formation other than ours.
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Canakinumab in the Treatment of Erosive Hand Osteoarthritis: A Case Series

Erosive hand Osteoarthritis (EOA) is a common and debilitating form of hand OA for which there are no proven or efficacious therapies. Interleukin-1 beta (IL-1β) plays a prominent role in OA joint inflammation. Canakinumab is a selective IL-1β inhibitor.
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Immunosenescence in Humans: Changes to the Aged T Lymphocyte Population in Response to Persistent Cytomegalovirus Infection

Immunosenescence describes the decrease in immune function with advancing age, a phenomenon that is associated with changes in the B and T lymphocyte populations. CD8+ T cells display the most dramatic phenotypical and functional changes within the T cell compartment whereby the cohorts of effector and memory T cells expand while the total population and diversity of naive T cells both decline.
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Retained Mesoappendix Fat Nodule Mimicking Appendicitis

Appendicectomy is one of the commonest emergency surgery performed across the globe. Long term complication post appendicectomy are rare. Chronic pain post operatively can be a debilitating problem, often without identifiable underlying cause.
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Sacrococcygeal Teratoma in a Developing Community

An epidemiologic data pool was formed from cases of SCT submitted as surgical specimens to a Reference Pathology Laboratory serving the Igbo Ethnic Group in South-Eastern Nigeria.
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The Effect of Interleukin-6-Type Cytokines and Adiponectin on MAPK Activation in the Immortalized Human Chondrocyte C28/I2 Line and Normal Human Chondrocytes

The C28/I2 line of immortalized juvenile human chondrocytes was employed to determine the extent to which recombinant human (rh) interleukin-6 (rhIL-6), the interleukin-6-like cytokine, rh-oncostatin M, and the adipokine, rh-adiponectin, activated extracellularsignal regulated kinase (ERK1/2), p38α mitogen-activated protein kinase (p38α MAPK) and c-Jun-amino-terminal kinase (JNK).
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Warfarin-Induced Tissue Necrosis (WITN): Case Report and Literature Review, A Proposed Name Change

Warfarin is the most frequently prescribed oral anticoagulant in the United States. Its indications range from treatment of deep venous thrombosis and pulmonary emboli to the prophylaxis and treatment of thromboembolic conditions associated with atrial fibrillation and cardiac valve replacement. While bleeding is the most commonly encountered complication warfarin induced skin necrosis (WISN) can be a rare complication. Extensive skin and deeper tissue necrosis may be encountered requiring multiple surgical debridement and reconstructive procedures along with the medical management.
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Beta (1-3)(1-6)-D-glucan with strong effects on immune status in chicken: potential importance for efficiency of commercial farming

In face of the challenge of the emergent new diseases and the current efforts of the governments to ban growth-promoting antibiotics and to improve conditions and overall health of the farmed animals, new opportunities are created for natural, highly effective, cost affordable immunomodulators.
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Non-Functioning Adrenocortical Carcinoma (incidentaloma) - A Case Report and Review of Literature

Adrenocortical carcinoma is a rare endocrine tumour with poor prognosis. Herein we report a case of adrenocortical carcinoma which was non-functioning, and non-metastasizing. A female patient presented with vague abdominal pain and palpable lump on examination. A large sized adrenal mass on Ultrasonography (USG) and computed tomography was revealed. USG guided fine needle aspiration cytology was performed, the smears were highly suspicious of malignancy.
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Complex Traumatic Facial Degloving Injury

By definition, degloving is detachment of skin and subcutaneous tissue, most often affecting the limbs and extremities and occasionally the scalp. Degloving generally occurs from high-energy trauma. This paper describes an extreme case of traumatic facial degloving injury. This is an extremely rare condition, as the patient survived despite the risk of imminent death. This case report addresses the decisions made regarding the emergency management, prevention of necrosis and infection by surgical debridement and timely repair of the vital soft tissue structures that guided the management.
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Pharmacy Compounding Quality Control and Pharmaceutical Development Strategies for Seventeen alpha Hydroxyprogesterone Caproate in Prevention of Preterm Delivery

Seventeen alpha hydroxyprogesterone caproate (17-OHPC) is the only FDA-approved drug labeled for prevention of preterm delivery. This drug is also available as a compounded product from licensed compounding pharmacies. This article reviews the FDA approval history and pharmacy compounding quality control data of 17-OHPC, as well as briefly discusses possible future pharmaceutical development strategies for 17-OHPC.
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The Flesh Fly Sarcophaga (Liopygia) crassipalpis Macquart 1839 as an Invader of a Corpse in Calabria (Southern Italy)

We present an indoor forensic case that occurred in spring 2013 in Cosenza (southern Italy). The entomological evidence collected at the scene consisted of Calliphoridae (Calliphora vicina, Lucilia sericata), Sarcophagidae (Sarcophaga crassipalpis), Fanniidae (Fannia scalaris) and Muscidae (Hydrotaea ignava).
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