Articles Related to neuroprotective
Investigation of Neuroprotective Effects of Ripasudil in Mechanic Optic Nerve Injury Model
Purpose: We aimed to create mechanic optic nerve injury model in rats and investigate the neuroprotective effects of
ripasudil on retinal ganglion cells.
Study Design: Experimental study
Methods: Mechanic optic nerve injury model was created in the right eyes of male Wistar rats (n=15). Rats were divided
into three groups: glaucoma model with sham treatment (group1) and 20 µM intravitreal ripasudil treatment (group 2)
and 50 µM intravitreal ripasudil treatment (group 3). Treatment was applied intravitreally and rats were sacrificed at the
end of 4 weeks. Glial fibrillary acidic protein (GFAP), Brn-3a antibody,anti- Iba1 was examined by immunohistochemistry.
Results: The number of Brn-3a positive RGC in the mechanical optic nerve injury model was 5.33 ± 2.08 (min: 3, max: 7)
in sham group, 10.25 ± 2.63 (min: 8, max: 14) in 20 µM group and 16.75 ± 5.43 (min:9, max: 21) in 50 µM group (p <0.05).
GFAP positive RGC counts were recorded as 24.33 ± 2.08 (min: 22, max: 26) in sham group, 16.75 ± 1.70 (min: 15, max:
19) in 20 µM group and 13.00 ± 4.08 (min:10 , max: 19) in 50 µM group (p <0.05). Ripasudil treatment also decreased Iba1
expression in the retina of mechanic optic nerve injury groups. In addition, ripasudil treatment prevented apoptotic cell
death by increasing Bcl-xL protein expression and preserved Tfam protein expression in the retina.
Conclusions: Our experimental study has shown that ripasudil is neuropreotective in mechanical optic nerve injury
model.
A Novel Neuroprotective and Antioxidative Efficacy of a Unique Combination of Standardized Huperzia serrata, Convolvulus pluricaulis and Celastrus paniculatus Extracts
Physical and environmental stress in conjunction with hectic lifestyle and unhealthy food habits are the major cause of diverse neurodegenerative disorders. Oxidative neuronal injury and acetylcholine deficiency have a major impact on learning and memory retention. Most of the treatment strategies are based on the improvement of cholinergic function in the brain and one of the emerging therapeutic targets is to enhance the acetylcholine level in the brain. Standardized botanical extracts including Huperzia serrata (1% Huperzine A, CogniUp), Convolvulus pluricaulis (SP) and Celastrus paniculatus (JY) have been demonstrated to attenuate brain function by serving as a natural acetylcholinesterase (AChE) inhibitor.
Case Studies of 17 Patients
This retrospective review of 17 patients suggests an increased risk of adverse events including premature death with opiate discontinuation long after withdrawal stage. The results are consistent with previously reported yet not fully understood – opiate associated neuro protective mechanism – against premature death for some vulnerable subgroups.
Editorial Board Members Related to neuroprotective
Yan Zhou
Associate Professor
Department of Pharmacology
Guangxi Medical University
China
Department of Pharmacology
Guangxi Medical University
China
SANTAMARIA RITA
Associate Professor
Department of Pharmacy
University of Naples Federico II
Italy
Department of Pharmacy
University of Naples Federico II
Italy
Guey-Jen Lee-Chen
Professor
Department of Life Science
National Taiwan Normal University
Taiwan
Department of Life Science
National Taiwan Normal University
Taiwan
MENG-YANG ZHU
Associate Professor
Department of Pharmacology
Quillen College of Medicine
East Tennessee State University
United States
Department of Pharmacology
Quillen College of Medicine
East Tennessee State University
United States
Alok Dabi
Assistant Professor
Department of Neurology and Neurosurgery
University of Texas Medical Branch (UTMB)
United States
Department of Neurology and Neurosurgery
University of Texas Medical Branch (UTMB)
United States