Articles Related to pharmaceutical

In literature are reported various use of activated charcoal AC and derivates in biopharmaceutical purifications.Aim of this work is to verify impurity proficle when using this technology.Various commercial products are reported here but it is not the scope of this work put in relation with any toxicological reaction: only to describe the technique used in this field.Because various drugs and bioproduct need purification steps it is if of interest to see some material science peculiarity

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The purpose of this review is to highlight environmentally sound disposal methods of veterinary pharmaceutcals wastes and the risks associated with its improper disposal, with a systematic review. Pharmaceuticals are produced and used in large volumes increasingly every year throughout the world. Medicinal waste products are medicinal products which are not fit for sale or supply. Waste produced in veterinary practice in common with other medical disciplines can be broken down into general waste similar to household waste, clinical waste and hazardous waste. Disposal of pharmaceutical compounds is becoming a complex environmental issue. The safety and health of the environment is directly affected by the disposal methods. Improper medical waste disposal and management causes all types of pollution (air, soil, and water). Proper waste management have to be undertaken to ensure that it does not affect the environment and not cause health hazards to the people living there. Different types of medical waste require different disposal techniques. The appropriate safe disposal method recommended will depend principally on the pharmaceutical dosage form of the drugs. One of the best advisable veterinary waste disposal practices is to store the waste properly before collection and transportation. Some general medical waste can be disposed of in landfill, others require specialist treatment such as a medical incinerator. Appropriate safety precautions, which minimize the risk to the health and safety of pharmacy staff, should be taken when handling medicinal waste products. Extra precautions should be taken by staff in high-risk groups as they may be at increased risk if they come into contact with particular substances. The cost of pharmaceuticals waste disposal comprises of direct costs of supplies and materials used for collection, transport, storage, treatment, disposal, decontamination and cleaning, the cost of labor and material for training and maintenance, and will vary depending on the treatment method chosen, the capacity of the treatment facility and according to the waste quantity and quality.

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The present research deals with the development of a stability indicating reverse phase HPLC with PDA detector method for the determination of Armodafinil Agilent XDB-C18, 150×4.6mm, 5µm or Equivalent column. The present research deals with the development of a stability indicating reverse phase HPLC with PDA detector method for the determination of Armodafinil Agilent XDB-C18,

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The Indian mulberry or Noni (Morinda citrifolia L.) is one of the emerging sources of natural antioxidants for herbal and pharmaceutical industry. The genus Morinda has more than 150 species in which M. citrifolia is identified as most important for health and economic point of view. Present study revealed significant (p < 0.05) diversity in 33 genotypes of M. citrifolia from Andaman and Nicobar Islands (India) for phyto-constituents. The promising genotypes viz. FRG-14, JGH-5, TRA-1, TRA-2 and HD-6 were identified for commercial uses. Correlation analysis in M. citrifolia germplasm showed strong correlation between carotenoids and ascorbic acid (r2 =0.973; p<0.05), tannin (r2 =0.598; p<0.05), flavonoids (r2 =0.691; p<0.05) and phenol (r2 =0.598; p<0.05). The genotypes showed wide range for antioxidant capacity which showed positive correlation with carotenoids (r2 =0.335; p<0.05), flavonoids (r2 =0.249; p<0.05) and Cu (r2 =0.953; p<0.05), Mn (r2 =0.953; p<0.05) and Mg (r2 =0.582; p<0.05). The diversity analysis is useful for designing breeding strategies for phyto-nutrient rich genotypes for better recovery in health products.

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This article summarizes the advantages of orally disintegrating tablets (ODTs) as well as critical issues during evaluation of ODTs such as bioequivalence and challenges and limitations of ODTs and finally present and the future of ODTs. ODTs have received everincreasing demand and the field has become a rapidly growing area in the pharmaceutical industry.

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The metabolism, pharmacokinetics, excretion and distribution of a sodium-glucose co-transporter (SGLT 2) inhibitor, empagliflozin, were studied in mice, rats and beagle dogs following a single oral or intravenous administration of [14C]-empagliflozin. Empagliflozin was well absorbed in all species after oral administration.

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Recently, transdermal drug delivery system (TDDS) has become a more and more important approach to administering drugs. Based on its advantages, which are not achievable by other modes of administration, many researchers are dedicated to the study of it, and have made great progress. Although the skin offers a painless interface for systemic drug delivery, it also presents limitations which are mainly caused by the stratum corneum.

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The objective of this study was to evaluate the encapsulation performance of Croscarmellose sodium, a superdisintegrant in a low-dose, poor-solubility drug formulation and the in-vitro dissolution performance of the Piroxicam capsules. Preparation, characterization and evaluation of the effects of the different concentrations of carmellose sodium and the amount of dried starch on in-vitro dissolution of Piroxicam capsules. Piroxicam was chosen for its very low solubility in biological fluids, which result in poor systemic bioavailability after oral administration. Piroxicam can be categorized as Class II drugs according to the Biopharmaceutics Classification System.

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Seventeen alpha hydroxyprogesterone caproate (17-OHPC) is the only FDA-approved drug labeled for prevention of preterm delivery. This drug is also available as a compounded product from licensed compounding pharmacies. This article reviews the FDA approval history and pharmacy compounding quality control data of 17-OHPC, as well as briefly discusses possible future pharmaceutical development strategies for 17-OHPC.

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The aim of this manuscript is to study cyclodextrins (CDs) as a potential excipient to suppress bitterness and enhance palatability of pediatric liquid preparations for Cetirizine, an extremely bitter drug. Natural α, β and γ CDs; and β CD derivatives such as hydroxyl propyl (HP), randomly methylated (RM) and sulfobutyl ether (SBE) β-CDs were screened in different molar ratios of 1:1, 1:2 and 1:3 for their inhibition of the extremely bitter taste of Cetirizine using the human gustatory sensation test.

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The present investigation was undertaken to evaluate the therapeutic efficacy and safety of Crominex 3+ (a complex of trivalent chromium, Phyllanthus emblica (Amla) extract and purified Shilajit) in moderately arthritic dogs.

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The objective of this investigation was to evaluate the efficacy and safety of purified Shilajit in moderately arthritic dogs. Ten client-owned dogs in a randomized double-blinded study received either a placebo or Shilajit (500 mg) twice daily for a period of five months. Dogs were evaluated each month for physical condition (body weight, body temperature, heart rate, and respiration rate) and pain associated with arthritis (overall pain, pain from limb manipulation, and pain after physical exertion).

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Researchers have been inventing new drugs since time immemorial. Of late it is established that the development of new drugs alone is not sufficient to ensure progress in drug therapy. The missing link is a potential strategy.It involves the apt selection of drug carrier systems.

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Capsaicin, an active ingredient of Capsicum fruit, is currently undergoing “revival” in the clinical management of pain. However, the choice of its formulation is rather limited to the use of “old-fashioned” tinctures and recently the patches. In an attempt to improve the therapeutic outcome and develop its skin-friendly formulation, we prepared the vesicle-based drug delivery system with capsaicin.

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Atopic dermatitis, also known as eczema, affects about 10-20% of children in the UK and about 1-3% of adults [1]. The incidence of atopic dermatitis has increased as much as 3 fold in the past 40 years

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