Articles Related to psoriasis
Erythodermic Psoriasis Succesfully Treated with Guselkumab
Erythrodermic psoriasis (EP) is severe and potentially life-threating variant of psoriasis.1 EP is defined as psoriasis involving more than 80% body surface area (BSA). In recent years the treatment options for EP have expanded; however international guidelines are lacking and the evidence-based treatment choices like conventional therapies and biologics are mainly from small case series or case report.2-3Guselkumab is a fully human monoclonal antibody designed to bind to the p19 subunit of interleukin-23 (IL-23), that inhibits the inflammatory cascade in psoriatic skin. IL-23 plays a central role in T-helper (Th)17 cell stabilization and survival as well as production of IL-17A, a pro-inflammatory cytokine involved in the pathogenesis of psoriasis.
Infantile Acute Generalized Pustular Psoriasis: A Case Report
Generalized pustular psoriasis (GPP) is an acute and uncommon form of psoriasis, representing about 3% of all psoriasis cases. Triggers may include streptococcical infections, emotional stress, vaccinations and exposure to medications such as penicillin. Systemic therapy is often necessary for GPP, since it may rapidly evolve, leading to significant and potentially fatal complications. Here, we describe the case of a 5-year-old male presenting with diffuse erythema, confluent scaly plaques and painful pustules localized on the trunk and limbs. Systemic manifestations such as fever, general lymphadenopathy and arthritis were also observed. To date, no standardized treatment guideline exists for infantile acute generalized pustular psoriasis. Our patient responded successfully to cyclosporine treatment within 4 weeks without any side effects. Thus, cyclosporine could be considered a useful agent in cases of pediatric GPP, keeping in mind its side effect profile in child population.
MRI of the Psoas Major Muscle: Origin, Attachment, Anatomical Variants and Correlation with the Lumbar Disc Extrusion
To verify the psoas major muscle (PMM) anatomical origin and variants, to evaluate the PMM attachment to the lumbar disc and variants, and to search for correlation between the anatomic variants of PMM attachment to the disc and disc extrusion.
Topical Delivery System for Phytochemicals: Capsaicin and Capsicum Tincture
Capsaicin, an active ingredient of Capsicum fruit, is currently undergoing “revival” in the clinical management of pain. However, the choice of its formulation is rather limited to the use of “old-fashioned” tinctures and recently the patches. In an attempt to improve the therapeutic outcome and develop its skin-friendly formulation, we prepared the vesicle-based drug delivery system with capsaicin.
Editorial Board Members Related to psoriasis
Nicola Balato
Associate Professor
Department of Dermatology
School of Medicine
University of Naples Federico II
Italy
Department of Dermatology
School of Medicine
University of Naples Federico II
Italy
T Theivasanthi
Assistant Professor
Kalasalingam University
Krishnankoil
India
Kalasalingam University
Krishnankoil
India
Adam Reich
Professor
Department of Dermatology
University of Rzeszow
Poland