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Gliomatosis Cerebri: A Case Report

Background: Gliomatosis cerebri is a rare primary brain tumor that can have extensive infiltration into the brain parenchyma. It can affect any age group and often has poor clinical outcomes. Given its unique pathology, presentation and treatment can be challenging to recognize and efficaciously treat
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A Case Report: Delayed Onset Urinary Tract Injury after Laparoscopic Hysterectomy

Lower urinary tract injury in hysterectomy is rare, but once it occurs, the consequence can be deteriorating. We experienced late onset urinary tract injury that developed as late as 15 days after laparoscopic hysterectomy. The objective of this case report is to alert all gynecological laparoscopists that such late onset complication may happen to any of patients.
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Solitary Adrenal Metastasis: A Case Report of Aberrant Behavior of Prostate Cancer

A Caucasian male with prostate cancer under androgen deprivation therapy after radiotherapy for a locally advanced lesion. Positron emission tomography/Computed Tomography revealed an adrenal lesion. The mass was removed, and histopathological examination showed adenocarcinoma of prostatic origin. Prostate-specific antigen decreased dramatically after adrenalectomy
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A Case Report of Peripheral Giant Cell Granuloma

Peripheral giant cell granuloma (PGCG) is a rarely seen benign lesion at soft oral tissue. In this report, the patient had a history of central giant cell granuloma at the left mandibular posterior region. The lesion was excised two years ago. Patient was consulted to our hospital for soft tissue growth at right maxillary anterior region. Excisional biopsy was planned and the lesion was examined histopathologically. Giant cell reparative granuloma was described and routine examination was advised to the patient
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A Novel Coenzyme Q8A Mutation in a Case with Juvenile-Onset Coenzyme Q10D4: Case Report and Literature Review

Primary coenzyme Q10 deficiency-4 (CoQ10D4) is an autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Molecular pathology responsible for clinical findings is mitochondrial respiratory chain dysfunction. The main clinical manifestation involves early-onset exercise intolerance, progressive cerebellar ataxia and movement disorders. Some affected individuals develop seizures and have mild mental impairment, indicating variable severity.
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Treatment of Erdheim-Chester Disease with High Dose Pegylated IFN-α: a Case Report and Literature Review

Erdhein-chester disease is a rare non-Langerhans histocytes that can involve multiple systems, with bone involvement as the most common. We reports a 39-year-old female who visited the hospital due to pain in both lower limbs, combined with clinical manifestations, imaging, and laboratory tests, Erdhein-Chester disease was prelimi narily diagnosed. The diagnosis was confirmed by the presence of BRAF V600E mutation and tissue cells on biopsy of the right tibia. We discussed the disease based on literature review, aiming to improve the understanding of clinicians.
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Disseminated Blastomycosis: A Case Report

Blastomycosis is known for its propensity to mimic other illnesses, which often leads to incorrect or delayed treatment. Here we present a case report of a patient working in Wisconsin who was misdiagnosed as Tuberculosis since he was an Indian. The patient was not evaluated on endemic grounds for Blastomyces where he was working for couple of years. After he developed skin lesions along with increased shortness of breath, lesions were evaluated which showed large yeast cells resembling Blastomyces. The treating pulmonologist evaluated his occupational history and was revealed with endemicity for Blastomyces.
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A Case Report of Diffuse Ischemic Injury from Leptomeningeal Midline Glioma Metastases

Diffuse midline gliomas with the histone 3-lysine-27-methionine (H3K27M) mutation should be considered in the differential diagnosis of recurrent hemiparesis and headache in patients with midline brainstem lesions, even with the absence of contrast-enhancement. Early diagnosis is essential for prognostication and engagement in trials evaluating novel therapeutics such as ONC-201.
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Late Benign Gastrobronchial Fistula after Esophagectomy for Esophageal Cancer: A Case Report

Benign gastrobronchial fistula (GBF) is extremely rare but highly fatal complication of esophagectomy for upper gastrointestinal system cancers. We present a benign GBF after three years esophagectomy for esophageal cancer with presenting recurrent pneumonia. We choose wedge bronchoplasty without lobectomy and primary repair of gastric conduit as an approach.
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Fulminant Emphysematous Pyelonephritis: Case Report and Revision of the Literature

A 56-year-old woman with type 2 diabetes mellitus and multiple sclerosis presented to our emergency department with right flank pain, fever (38.6°) and dysuria. A computed tomography (CT) scan showed the right kidney hydronephrosis secondary to ureteral stone, therefore a percutaneous nephrostomy was placed. The next day the patient’s condition deteriorated rapidly; a new CT showed the presence of gas in the right kidney suspicious for emphysematous pyelonephritis (EPB) that needed an emergency nephrectomy. Thirtyfive days later the patient was discharged in good general condition.
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Buschke-Lowenstein Tumor of the Vulva: A Case Report

Buschke-Lowenstein tumor or giant condyloma acuminata is a rare disorder of the external genitalia, belonging to the group of verrucous carcinomas, and usually affects immunocompromised men. Human Papillomavirus (HPV) 6 and 11 are potentially involved in the pathophysiology. A detailed questioning, a rigorous clinical examination and complementary imaging are important to establish an accurate lesion assessment and an adapted management. Wide surgical excision is the treatment of choice.
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Idiopathic Pulmonary Hemosiderosis in a Middle-Aged Woman: a Case Report

Idiopathic pulmonary hemosiderosis (IPH) extremely rarely occurrs in adults according to current literature.We report one case of IPH in a middle-aged woman presenting with extensive central-predominant ground glass opacities and consolidation in the lungs. Since these imaging findings are not specific and can be similar to other diffuse pulmonary diseases, it is essential to have an deep understanding of this disorder. Imaging findings must be combined with clinical laboratory examination to make a diagnosis of IPH. Transbronchial lung biopsy (TBLB) is the gold standard for evaluation of suspected patients. We review the current literature and provide a recommendation based on discussion.
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Iatrogenic Laryngotracheal Stenosis in Children: a Case Report

Laryngotracheal stenosis is one of the important causes of pediatric airway obstruction, and the etiology can be classified as congenital and acquired. With the widespread use of tracheal intubation and tracheotomy in pediatric emergency, iatrogenic laryngotracheal stenosis is gradually replacing trauma and infection as the major cause of acquired laryngotracheal stenosis [1]. Nowadays, open surgery is the first choice for severe laryngotracheal stenosis cases [1,2]. Here, we describe a case of childhood iatrogenic severe laryngotracheal stenosis, and the reflection on the current treatment methods of children with laryngotracheal stenosis.
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Case Reports: Hepatic Sclerosing Hemangioma: A Diagnostic Dilemma!

Haemangiomas are the most common benign incidentally detected hepatic lesions with a prevalence of ~20%. Most of them have typical imaging features and are easily diagnosed on triple phase studies. These are capillary, flash and giant hemangioma. Another subset of haemangiomas are Sclerosing hemangiomas or atypical haemangioma; these are sclerosed, thrombosed and/or hyalinised due to which these are heterogenous and show varied appearance making them difficult to diagnose.
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Case Report: Severe Sequelae of Sleep Disorders

We report 2 cases of severe injuries in patients with sleep disorders. The first patient sustained multiple orthopedic traumas as sequelae of REM sleep behavior disorders (RBD). The second patient sustained a severe TBI as a result of restless legs syndrome (RLS). To our knowledge, there are only 2 reported cases of severe orthopedic traumas (cervical spine fractures) as a result of RBD and no reported cases of severe TBI from RLS.
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Editorial Board Members Related to report

Ashraf Naeem

Associate professor
Department of Anatomy & Embryology
Zagazig University
Egypt

Vikram Khanna

Orthopedic Surgeon
Ranjana Hospital
Allahabad

Kaveh Ostad-Ali-Askari

Department of Civil Engineering
Islamic Azad University
Iran

HARRY E. RUDA

Professor
Department of Materials Science and Engineering
University of Toronto
Canada

Norio Yasui-Furukori

Associate Professor
Department of Neuropsychiatry
Hirosaki University School of Medicine
Japan

Sanjay D. Deshmukh

Professor
Department of Pathology
Smt. Kashibai Navale Medical College and General Hospital
India

Tingzhong Yang

Professor and Director of Social Medicine
Zhejiang University
China

Marc G. Sturgill

Associate Professor and Chair
Department of Pharmacy Practice & Administration
Ernest Mario School of Pharmacy
Rutgers University
United States

NATASHA TASEVSKA

Assistant Professor
School of Nutrition and Health Promotion
Arizona State University
United States

Sheila Crewther

Professor
School of Psychological Science
Univerity of La Trobe
Australia
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