Articles Related to retrospective analysis
Anti-Infectives do not Impact Treatment Response to Immune Checkpoint Inhibitors: a Single Center Retrospective Analysis
Immune-checkpoint inhibitors (ICI) have provided groundbreaking advancements for a
variety of malignancies. It has been of recent interest to identify predictive indicators of response to improve cancer
management using immunotherapy. The intestinal microbiome has been recognized as a potential predictor of ICI anti-
tumor activity. Antibiotics reduce diversity the overall composition of the gut microbiota, with effects seen as quickly as in
a single day. Post-antibiotic dysbiosis recovery varies depending on type and duration of exposure. Preclinical studies in
mice with advanced cancer treated with broad spectrum antibiotics have been associated with resistance to ICI treatment.
Malignant Scalp Tumors: Retrospective Analysis of 1000 Patients.
Background: Limited data on large cohort of patients with malignant tumors of the scalp are available in the literature. The
aim of this study was to review a large cohort of patients with malignant scalp tumors to determine epidemilogy, tumor
characteristics of this region and treatment.
Materials and Method: A retrospective review of patients with malignant scalp tumors diagnosed histopathologically
between 2005 and 2021 was performed. Demographic features and tumor characteristics were analyzed.
Results: A total of 1080 patients (M: F 3,5:1) were treated and followed up for a mean period of 42 months (12-120
months). Age at diagnosis ranged from 12 to 98 years. Most malignant scalp tumors (95,1%) occurred in those 50 years
or older and in bald patients (87%). Basal cell carcinomas (59,2%), squamous cell carcinomas (32,2%) and melanomas
were the most common histologic types. Incidence was highest on the frontal of temporal region (66,1%). Recurrence was
frequently in squamous and basal cell carcinomas but uncommon in melanoma.
Conclusions: Tumors of the scalp accounted about 8,01 % of all skin cancers. Tend to be basal and squamous cell carcinomas, many of which occur in the temporal and frontal region of bald men. The outlook for patients with scalp tumor is
positive, although we suggest excision margins of at least 3-4 mm and continued clinical vigilance is warranted given their
higher recurrence rates.
Predictive Value of ERCC1 Expression on Treatment Response to Cisplatin-Based Regimens in Small Cell Lung Cancer: A Retrospective Analysis
We aimed to determine whether the excision repair cross-complementation group 1 (ERCC1) expression predicts response to cisplatin-based chemotherapy in patients with small cell lung cancer (SCLC). This was a retrospective study, in which hospital files of 31 patients (29 males, 2 females; mean age, 62.26±7.71 years) were reviewed. All patients were treated with etoposide+cisplatin. The lung biopsy and mediastinal lymph node samples were applied anti-human monoclonal antibodies against ERCC1: immunohistochemical staining was considered positive if 25-100% of the cells showed nuclear staining, and negative if less than 25% of the cells showed negative or slight staining. Response to treatment was evaluated as regression (complete or partial response), progressive disease, or stable disease. Of the patients, 18 (58.1%) had limited-stage, and 13 (41.9%) had extensive-stage SCLC. Median follow-up duration was 15 months (range: 1-60 months). ERCC1 staining was positive in 9 of 31 patients (29.0%). In 12 patients (38.7%), tumor regression (complete or partial response) was obtained after chemotherapy. Tumor regression rate was higher in ERCC1 positive patients than those with negative ERCC1 expression (66.7% vs. 27.3%, p=0.036). In conclusion, high expression of ERCC1 was associated with higher response rate to cisplatin-based regimens in patients with SCLC.
The Role of Nursing in Scientific Investigation in Africa: A Retrospective Analysis
We think that there is a generalized opinion that nursing professionals have to possess a strong vocation for their profession, which can be compared with the priesthood. In Europe, during the Middle Ages, they were supported by the Catholic Church. It is believed that the first recorded aspects of nursing place the inception of the profession during the height of the Roman Empire, around 300 A.D. It was during this time that the Empire sought to place a hospital within every town under its rule.
Retrospective Analysis of 185 Occurrences of Clinical Neurological Signs in 181 South American Camelids
Medical records of each occurrence of neurologic signs in 181 South American Camelids admitted on 185 occasions (90 alpacas and 95 llamas) were evaluated. Age ranged from 0 days to 20 years, but 70.5% of cases were ≥ 1 year old. Specific clinical diagnosis was achieved by cerebrospinal fluid analysis (CSF), radiographs, computed tomography, laboratory testing, or necropsy in 74% of cases. 54% of cases survived; 46% of cases died or were euthanized. The most common diagnosis (31%) was parasitic myelopathy/encephalopathy (PME). CSF eosinophilia ≥10% was found in 85% of parasitic spinal migrations but only in 55% of intracranial migrations, and 73% had increased protein in CSF. There was a seasonal bias for PME with 79% of cases occurring between October and March. Survival of PME cases was 77% for spinal migration but only 7% when intracranial migration occurred. The most common diagnoses, excluding PME, were infectious disease (15%) and trauma (12%). Most trauma cases involved the cervical spine of which 50% survived.
Candidate Selection, Determinant Factor for a Good Result in Cardiac Retransplantation: our Experience
Cardiac retransplantation is the standard treatment for patients with advanced graft vasculopathy. It remains controversial due to the scarcity of donors and poor results when compared with the novo transplant.
Epidemiological Characteristics of Infections Associated with Culture Isolated Fusobacterium Nucleatum: A Retrospective Analysis
The pathogenic potential of Fusobacterium nucleatum and its significance in infections has gained new interest. This retrospective study assessed the epidemiology of patients with infections and culture isolated F. nucleatum at two county hospitals in Houston, Texas. Clinical, epidemiological and microbiological data were obtained from the electronic medical record for both Ben Taub General Hospital and Lyndon B. Johnson Hospital from January 1, 2002 to December 31, 2011.