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Articles Related to sclerosis

Selection of Disease Modifying Treatment (DMT) Relates to Patient’s DecisionMaking Competence in MS

Background: In Multiple Sclerosis, more efficient disease modifying treatment (DMT) are often accompanied by higher risks and side effects. Selecting the optimal DMT demands from patients and doctors therefore a complex decision-making process weighing risks and benefits. Patients and doctors often prefer to share responsibility when making these treatment decisions, but this shared decision-making model requests decision-making competence on both sides. The aim of our online study was to investigate whether patients’ decision-making competence relates to DMT selection. Method: 197 patients participated in the online survey, advertised by two patient organizations. Patients reported their DMT and who decided for or against a DMT: their neurologist, themselves, or both. We measured decision-making competence with two tasks from the Adult Decision-Making Competence Battery (A-DMC), the ability to follow decision rules and the consistency of risk perception. Perceived impairment of the disease was measured with Patient Determined Disease Steps (PDDS). Results: The ability to follow decision rules varied with the potency of the DMT. Patients receiving basic DMT were better able to follow decision rules compared to patients receiving medium DMT. Patients who did not take any DMT stated more frequently that this decision was their own choice and independent of their doctor’s advice. Conclusions: If patients without DMT decided against this treatment on their own behalf, doctors and caregivers potentially have to strengthen their effort to reach out to the patient and to ensure the decision is well taken.
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Clinical Stabilization of a Patient with Amyotrophic Lateral Sclerosis Due to Comprehensive Management

Amyotrophic lateral sclerosis (ALS) is a progressive nervous system disease that affects nerve cells in the brain and spinal cord, resulting in paralysis, inevitably, death. We herein report a case of a 67-year-old woman diagnosed with Amyotrophic Lateral Sclerosis (ALS) for one year presented with type II respiratory failure who has been under comprehensive management and kept using Non-Invasive Ventilator (NIV) for more than four months in a stable condition. In this report, we try to discuss the multidisciplinary approach to optimize the functioning of the patients and to care the patients with ALS in order to improve their quality of life (QOL).
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Functional Outcomes of Stapes Surgery with Titanium and Teflon Prosthesis: Randomized Controlled Trial

Prosthesis material and design is thought to have a role in effective sound transmission, rate of complications and success of stapes surgery. Titanium has been shown to be a promising material in this regard. We compared the intra-operative events, complication rate and the hearing outcomes results of stapes surgery using titanium versus fluoroplastic piston prosthesis.
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Multiple Sclerosis Disease Modifying Therapy and Cancer risks

Multiple sclerosis (MS) is a chronic inflammatory condition not commonly associated with cancer. Although since 1993 with the introduction of disease modifying therapies (DMTs), changing the natural history of the disease, cancer risk appears associated with some of these new therapies. We present the most common risks associated with each DMTs.
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Hyperkinetic Manifestation in a Patient with Hippocampal Atrophy

Describes a case of a patient that presents with hippocampal atrophy leading to hyperkinetic crises of parietal-occipital origin
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DNA Polymerase as Therapeutic Intervention for Treating Patients with Multiple Sclerosis

In recent years, increasing evidence has pointed to the potential role of fibrinolysis in the pathogenesis of MS. Based on hypotheses describing the aggressive autoimmune responses observed in MS patients, a result of impaired between (t-PA and PA1-1) which are a key molecules in both fibrinolysis and extracellular proteolysis. The present study was done to investigate the therapeutic potential of polymerase enzyme in modulating the changes occurred between levels of Tissue- type plasminogen activator (t-PA) and its inhibitor (PAI-1) in patients with multiple sclerosis. A pilot study was carried out on a total of twenty-one patients (17 females, 4 males; aged 22-46 years) with demyelination suggestive of MS and clinically silent T2 brain lesions on magnetic resonance imaging (MRI).
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A Case of Bulbar Amyotrophic Lateral Sclerosis with Mild Cognitive Impairment

It is still contentious whether amyotrophic lateral sclerosis (ALS)-Alzheimer’s disease (AD) cases comprise a combined disease or represent a coincidental association. We describe the case of a 78-year-old white male with a 12-month history of bulbar muscle weakness and mild cognitive impairment. Hallmarks of AD pathology were present and associated with diffuse congophilic angiopathy. The motor cortex did not show a loss of motoneurons. The anterior horns of the medulla oblongata and hypoglossal nuclei showed skein-like cytoplasmic inclusions and ubiquitin and TDP43 phosphate positive staining. No signs of FTLD were detected. The pathological results suggest that, in this case, ALS and AD pathology appeared to be independent.
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Sjögren’s Syndrome - Oral Changes, Advanced Diagnosis, and Management - A Case Report

Sjögren syndrome (SS) is chronic, systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands. It is an elaborate involvement of the lacrimal and salivary glands, which eventually lead to keratoconjunctivitis sicca and xerostomia.
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Bilateral Malleus Ankylosis: a Case Report

Malleus ankylosis known as House syndrome is very rare. It represents 38.1% of congenital malformation of the middle ear [1] if stapes ankylosis is associated.
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Vasculitis Associated with Chronic Lymphocytic Leukemia

A patient is present who has chronic lymphocytic leukemia (CLL) and developed a vasculitis involving the skin and large vessels along with immune complex mediated glomerulosclerosis. Both vasculitis and immune complex nephritis are rare manifestations of CLL.
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A Highly Efficient Culture Technique for Derivation of Motor Neurons from Human Umbilical Cord Derived Mesenchymal Stem Cells

Motor Neuron Diseases (MND) are a group of progressive neurological disorders that destroy motor neurons, cells that control essential muscle activity. Despite the advances in treatment modalities, the overall survival rate has not changed for decades. This is mainly due to the lack of effective methods.
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Networks: Elucidating Experimental Data by Differential Protein-Protein Interactions

Recently, the pathogenesis of coronary atherosclerosis - a primary cause of cardiovascular disease – studied in a swine model has been investigated by considering in particular the effects of a high cholesterol diet lasting 8 or 16 weeks.
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Acculturation and Subclinical Atherosclerosis among U.S. South Asians: Findings from the MASALA study

Longer duration of residence among immigrants to the United States, a proxy measure of acculturation, has been associated with higher subclinical atherosclerosis. South Asian immigrants are the second fastest growing immigrant group in the U.S. but little is known about the effects of acculturation with atherosclerosis in this high cardiovascular risk population.
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Anti-Arthritic Efficacy And Safety Of Crominex 3+ (Trivalent Chromium, Phyllanthus emblica Extract, And Shilajit) In Moderately Arthritic Dogs

The present investigation was undertaken to evaluate the therapeutic efficacy and safety of Crominex 3+ (a complex of trivalent chromium, Phyllanthus emblica (Amla) extract and purified Shilajit) in moderately arthritic dogs.
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Resolution of Complete Atrioventricular Block in a Patient with Severe Hypothyroidism

Causes for syncope are multifaceted. Hormonal etiology, specifically hypothyroidism, is associated with cardiac arrhythmias. Sinus bradycardia, low voltage, nonspecific T-wave changes and dissociative atrioventricular (AV) abnormalities are some of descriptive electrocardiographic features.
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Editorial Board Members Related to sclerosis

Lizhong Wang

Associate Professor
Department of Genetics
University of Alabama
USA

Rashmi Bansal

Professor
Department of Neuroscience
University of Connecticut Health Center
United States

Liqing Yu

Associate Professor
Departments of Animal and Avian Sciences
University of Maryland
United States

Eric Fung

Professor of Pharmacology
Department of Oral Biology
University of Nebraska Medical Center College of Dentistry
United States

Michael P. Namaka

Associate Professor
Faculty of Pharmacy and Medicine
University of Manitoba
Canada

Zhonghua Sun

Associate Professor
Department of Imaging and Applied Physics
Curtin University
Australia

Sohail Mushtaq

Senior Lecturer
Department of Clinical Sciences
University of Chester
United Kingdom

Yu Huang

Professor
School of Biomedical Sciences
Chinese University of Hong Kong
Hong Kong

Ock K. Chun

Assistant Professor
Department of Nutritional Sciences
University of Connecticut
United States

Tatjana Rundek

Professor
Miller School of Medicine
University of Miami
United States
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