Articles Related to serotypes
Distribution of Dengue Virus Serotypes during the COVID 19 Pandemic in Sri Lanka
Background: Dengue virus (DENV) infection is highly endemic in Sri Lanka with frequent epidemics. Knowledge on DENV serotype distribution will provide important information on impending epidemics. Understanding the disease burden of DENV infection during COVID-19 pandemic is highly important.
Objective: To analyze the incidence of DENV infection and serotype distribution among clinically suspected patients with DENV infection during COVID-19 pandemic in Sri Lanka.
Study Design: This retrospective study analyzed 1796 plasma samples from patients with clinically suspected DENV infection received at Medical Research Institute (MRI), for testing of DENV RNA, from May 2019 to April 2021. Detection of viraemia and serotypes was performed using a commercially-validated serotyping real-time Reverse Transcriptase Polymerase Chain Reaction (RT-PCR). Demographic and clinical details were recruited from accompanying request forms. Results were analyzed using descriptive statistics and chi square testing.
Results: Of the samples 69.2% (n=1243) became positive for DENV RNA with 55.34% (n=688) belonging to patients under 16 years and 20.99%(n=261) to patients with severe infection. The vireamic rate ranged from 31.9% to 80.12% during different quarters of the study period. DENV-2 was detected in 40.2% (n=500) followed by DENV-3(37.97%,n=472) and DENV-1(15.44%,n=192) while co-infection with two different serotypes was observed in 5.79%(n=72). DENV3(47.5%,n=124) and DENV-2(39.46%, n=103) exhibited high percentage of positivity among patients with severe infection.
Conclusions: Incidence of Dengue virus infection in Sri Lanka showed a noticeable decrease during study period. DENV2 and DENV-3 exhibited dominance with re-emergence of DENV-1 and co-infection with multiple serotypes. DENV-2 and DENV-3 were detected with severe infection predominantly.
Non-Polio Enterovirus Meningitis in Children-Clinical Spectrum, Viral Serotypes and Outcome: Unusual Community Outbreak Experience at a Tertiary Care Centre from Oman
Enterovirus meningitis is one of the commonest viruses causing meningitis in children which is underdiagnosed. The
epidemiology of EV infections is not well studied in the Middle East and Arab Gulf Region. No Study was conducted in Oman to explore
more about viral meningitis. This study will help to review enterovirus meningitis in order to guide management and patient care in
Oman and will help to decrease the cost of treatment by avoiding unnecessary investigations.
Case Series of Pneumococcal Meningitis in the Post 13-valent Pneumococcal Conjugate Vaccine Era
Streptococcus pneumoniae is a leading cause of meningitis. Although rates of bacterial meningitis have decreased after pneumococcal
conjugate vaccine introduction, pneumococcal meningitis has not been eliminated. In this case series, we describe the presentation,
serotypes, and outcomes of 11 children with pneumococcal meningitis at a tertiary children’s hospital after the 13-valent pneumococcal
conjugate vaccine (PCV13) was introduced, from 2011-2013. The median age of children with meningitis was 7 years. The majority
of the isolates (82%) were susceptible to penicillin. Most isolates (73%) were serotyped and there was no evidence of disease caused
by serotypes contained in PCV7