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Articles Related to solid lipid nanoparticles

An Introduction to the Approaches of Novel Drug Delivery Systems for Acquired Immune Deficiency Syndrome (AIDS)

The currently available anti HIV agents have several drawbacks such as short half life, low bioavailability, poor CNS penetration and retention, hepatic first pass metabolism, undesirable side effects and frequent dosing regimen.
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SLNs Based on Co-Processed Lipids for Topical Delivery of Terbinafine Hydrochloride

Terbinafine hydrochloride (TH) is first line drug against treatment of onychomycosis; which is the commonest fungal infection of nail plate. However, strong barrier property of nail plate restricts the effective topical treatment of onychomycosis. In this study, TH loaded solid lipid nanoparticles (SLNs) were prepared and subsequently incorporated into a gel system. SLNs were prepared by high pressure homogenization (HPH) technique using glyceryl monosterate (GMS), compritol 888ATO and a co-processed lipid. They were evaluated for particle size, polydispersity index, zeta potential, % entrapment efficiency (%EE), % drug loading (%DL), drug content and in-vitro drug release. Optimized SLNs were incorporated into chitosan gel and further evaluated for in-vitro drug release and ex-vivo antifungal study.
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Editorial Board Members Related to solid lipid nanoparticles

R. SURESHKUMAR

Assistant professor
Department of Pharmaceutics
JSS College of Pharmacy
India

ALAA EL-DEEN BAKRY YASSIN

Associate Professor
Department of Pharmaceutical Sciences
King Saud bin Abdulaziz University for Health Sciences
Saudi Arabia
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