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Articles Related to stem cells

Introduction of Stem Cells in Ophthalmology

Stem cells are relatively undifferentiated, with unlimited proliferative ability; self-renewal capability and also they can differentiate into specialized cells. Somatic stem cells in adult organisms are responsible for regenerating and self-renewing tissue. Many different stem cell types reside in the eye.
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Former Effective Immunotherapy without Adverse Events of Inoperable Epithelial Ovarian Cancers and a Prospect for the Immune Prophylaxis

Current cancer treatments by immune checkpoint blockades are limited due to severe adverse events caused by alteration of the immune system required for homeostasis of normal tissues. Common cancer chemotherapy alters the quality of patients’ lives. Platinum-based treatment can lead to severe neurotoxicity with chronic debilitation. Additionally, survival of patients with epithelial ovarian cancers (EOCs) has remained poor despite extensive cytoreductive surgery, high dose chemotherapy, checkpoint blockades and immunotherapies effective in some other types of cancer. The pathobiology of EOC cancer stem cells (CSCs) is not well understood. Observations demonstrate that EOCs exhibit in vivo two distinct CSC types - perivascular diploid CSCs dividing asymmetrically with the help of the host suicidal CD8+ T cells, and haploid CSCs at the cancer abdominal surface originating from meiosis I cytokinesis of bulk surface cancer cells. The perivascular CSCs contribute to the cancer cell bulk and, via left ovary venous blood, can cause EOC liver metastases. Haploid CSCs released from the bulk cancer surface cause the common pelvic and abdominal EOC spread. Former elimination of the host antibodies blocking T cell effectors by intermittent doses of cyclophosphamide exhibiting significant immunomodulatory anticancer effects, facilitation of the immune system reactivity against alloantigens of cancer cells by blood transfusions, and augmentation of anticancer immunity by bacterial toxins, resulted during the subsequent treatment-free period into rejection of inoperable EOCs without any adverse events during the treatnment. To help prevent cancer relapses, patients treated for advanced primary epithelial cancers should be considered as candidates for continuously stimulating immune anticancer activity by treatments such as daily metformin and weekly lentinan consumptions.
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Derivation of Induced Pluripotent Stem (iPS)-like Cells from Microminipig Somatic Cells by Sendai Viral Transduction of 4 HumanG, OCT4, SOX2, KLF4, and c-MYC

Research on the stem cell biology of the minipig is rapidly developing. Although research on mouse and human stem cells currently predominates over that in other species, data from these species have provided a good foundation for current and future porcine stem cell research. In addition, the increasing popularity of alternate-species models in the study of human diseases and disease mechanisms has spurred porcine stem cell research. As a source of pluripotent embryonic stem cells, the pig presents several challenges as compared with mice and humans.
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Mesenchymal Stem Cells from Different Tissues: Immune Status and Activity

Mesenchymal stem cells (MSCs) have been found in almost all tissues and due to their regenerative properties represent promising tools in cell-based therapy. Role of MSCs in tissue repair is strongly governed by their interplay with immune cells and regulating factors.
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Human Induced Pluripotent Stem Cells Derived from A Patient with Sporadic Alzheimer’s Disease Exhibit Altered Neuronal Proliferative Capacity

We generated two hiPSC clones from a patient with sporadic late-onset Alzheimer’s disease (AD-iPSCs), which expressed typical undifferentiated markers and passed standard pluripotency assays. Genome-wide microarray analysis revealed that AD-iPSCs were highly similar to control hiPSCs and hESCs, albeit with some noticeable differences in few genes, viz.: DNAJC15, GRPR, NAIP and SNORD116-18
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Mesenchymal Stem Cells in the Treatment of Patients with Chronic Spinal Cord Injury (ASIA A) with Residual Electrophysiological Function

Bone-marrow derived mesenchymal stem cells (MSC) represent an experimental form of therapy in the treatment of chronic spinal cord injury (SCI), up to two years after trauma.
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Efficient Method of Deriving Functional Endothelial Progenitor Cells From Hematopoietic Stem Cells

EPCs (Endothelial progenitor cells) are the precursors of endothelial cells that form the inner lining of blood vessels and are involved in neovascularization and re-endothelializaton of injured tissues. These cells have the potential for treating a multitude of angiogenic disorders giving a new hope in the arena of vascular biology. In the present study, we have demonstrated that cord blood derived expanded CD34+ cells can be differentiated into functional EPCs in vitro.
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A Highly Efficient Culture Technique for Derivation of Motor Neurons from Human Umbilical Cord Derived Mesenchymal Stem Cells

Motor Neuron Diseases (MND) are a group of progressive neurological disorders that destroy motor neurons, cells that control essential muscle activity. Despite the advances in treatment modalities, the overall survival rate has not changed for decades. This is mainly due to the lack of effective methods.
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Adults Mammary Stem Cell in Cow’s Milk: New Perspectives and Future Challenge

The discovery of the presence of stem cells and precursors with high regenerative potential in the mammary gland, hypothetically maintained throughout the course of the productive life of the dairy cow sheds an interesting perspective in the research which is interested to clarify all physiological clues and possible solutions to increase or maintain longer the potential production of dairy cows during life span of lactation.
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Editorial Board Members Related to stem cells

Qingsong Ye

Associate Professor
Department of Orthodontics
James Cook University
Australia

Murugan Ramalingam

Professor
Department of Centre for Stem Cell Research
Adjunct Professor at Tohoku University, Japan
Christian Medical College
India

Jianxun Song

Associate Professor
Department of Microbiology and Immunology
Pennsylvania State University
United States

Arvind Chhabra

Assistant Professor
Department Of Medicine
University of Connecticut Health Center
United States

Jinlian Hua

Professor
Shaanxi Centre of Stem Cells Engineering & Technology
Key Lab for Animal Biotechnology of Agriculture Ministry
Northwest A&F University
China

Xiaoyan Jiang

Professor
Department of Medical Genetics
University of British Colombia
Canada

Seyed Mahmoud Hashemi

Assistant Professor
Deaprtment of Immunology
Shahid Beheshti University of Medical Sciences
Iran

Jae Hwa Kim

Professor
Department of Orthopedics
CHA Bundang Medical Center
CHA University
Korea

Matthias Clauss

Associate Professor
Department of Medicine
Indiana University
United States

Inbo Han

Associate professor
Department of Neurosurgery
CHA University
South Korea
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