Top Links

Articles Related to tumor

Therapy-related Myeloid Neoplasms after Pediatric Solid Cancer in a Single Reference Cancer Center in Brazil

Pediatric cancer overall survival has increased due to improvements in treatment. However, long-term adverse effects are a challenge for this population. Secondary myeloid neoplasm (MN) is one of the complications of solid tumor treatment. Therapy-related myeloid neoplasms (t-MN), therapy-related acute myeloid leukemia (t-AML), and therapy-related myelodysplastic syndrome (t-MDS) are the most common events. The aim of this study was to report a large pediatric sample and the relevance of t-MN after pediatric solid tumor therapy. We conducted a retrospective study between 2000-2016 in a cohort of pediatric patients treated for solid tumors who developed a secondary MN by medical records review and analysis. Seven from 2178 pediatric patients who were previously treated for solid tumors, were diagnosed with t-MN in a reference cancer center in Brazil. The median age at primary tumor diagnosis was 12.8 years old. Osteosarcoma, atypical primitive neuroectodermal tumor (PNET), Ewing sarcoma, and retinoblastoma were the most frequent solid tumors associated with t-MN. Three patients had a story of familiar cancer, and one patient with osteosarcoma had Li-Fraumeni syndrome confirmed. The median latency period to secondary MN was ten months and the prevalence rate was 0.32%. Two patients developed t-MDS and five, t-AML. All these patients received cytotoxic agents’ high doses that may have been associated with t-MN development. t-MN initial control, as well as unfavorable cytogenetic abnormalities, may have contributed to the poor outcome. We described the rarity of t-MN related to previous solid tumor therapy in a large pediatric sample in a Brazilian Cancer Center and their poor prognosis.
View complete article: PDF  |  Full-text

A Case Report of Peripheral Giant Cell Granuloma

Peripheral giant cell granuloma (PGCG) is a rarely seen benign lesion at soft oral tissue. In this report, the patient had a history of central giant cell granuloma at the left mandibular posterior region. The lesion was excised two years ago. Patient was consulted to our hospital for soft tissue growth at right maxillary anterior region. Excisional biopsy was planned and the lesion was examined histopathologically. Giant cell reparative granuloma was described and routine examination was advised to the patient
View complete article: PDF  |  Full-text

A Case Report of Diffuse Ischemic Injury from Leptomeningeal Midline Glioma Metastases

Diffuse midline gliomas with the histone 3-lysine-27-methionine (H3K27M) mutation should be considered in the differential diagnosis of recurrent hemiparesis and headache in patients with midline brainstem lesions, even with the absence of contrast-enhancement. Early diagnosis is essential for prognostication and engagement in trials evaluating novel therapeutics such as ONC-201.
View complete article: PDF  |  Full-text

Buschke-Lowenstein Tumor of the Vulva: A Case Report

Buschke-Lowenstein tumor or giant condyloma acuminata is a rare disorder of the external genitalia, belonging to the group of verrucous carcinomas, and usually affects immunocompromised men. Human Papillomavirus (HPV) 6 and 11 are potentially involved in the pathophysiology. A detailed questioning, a rigorous clinical examination and complementary imaging are important to establish an accurate lesion assessment and an adapted management. Wide surgical excision is the treatment of choice.
View complete article: PDF  |  Full-text

CNS Gliosis not Neoplasia in Kabuki Syndrome: A Case Report of a Brain ‘Tumor

An eight-year-old boy with Kabuki Syndrome (KS) and an enlarging CNS mass is presented. The ‘tumor’ was discovered incidentally during MR imaging for a behavioral disorder and was located within the left globus pallidus. Retrospective review of previous MRIs showed no abnormality in the basal ganglia seven years earlier but a small region (a few pixels) of increased in T2 signal intensity three years earlier.
View complete article: PDF  |  Full-text

Cranial Vault Tumor Revealing Metastatic Thyroid Carcinoma

Distant metastases from follicular thyroid carcinoma are not uncommon, but bone localization in the cranial vault is extremely rare. Although these metastases have a poor prognosis, early diagnosis and appropriate treatment can improve quality of life. We report a case of follicular thyroid carcinoma revealed by a metastasis of the cranial vault initially diagnosed as meningioma.
View complete article: PDF  |  Full-text

Synchronous Contralateral Benign and Malignant Parotid Gland Tumors: Case Report

Multiple primary parotid gland tumors are rare, accounting for 1.7-5% of all parotid neoplasms, and the occurrence of bilateral parotid gland tumors is even lower (1.3-3.5%). These tumors can be synchronous or metachronous and the most common histologic type of bilateral parotid gland tumors is Warthin tumor (79.2-90%). Combined benign and malignant lesions and bilateral neoplasms of different histologic types are even less frequently found.
View complete article: PDF  |  Full-text

After Brain Tumor Surgery: Catheter-Related Bacteremia of Chryseobacterium indologenes Development in Central Nervous System of An Infancy. A Case Report

40-day male infant has admitted to the hospital by family. He has a complaint including lack of suction, vomiting, decreased of movements and continuous sleep about a week of ongoing. Brain computed tomography recognized a mass (with hyperdense hemorrhage) in the posterior fossa and right cerebellar hemisphere.
View complete article: PDF  |  Full-text

Cost-Effectiveness and Budget Impact Analysis of Recombinant Tumor Necrosis Factor-Thymosin Alpha 1 in a Complex Treatment of Metastatic Breast Cancer

Recombinant tumor necrosis factor -thymosin alpha 1 (TNF-T) has been used in Russian oncological practice for a number of years.
View complete article: PDF  |  Full-text

Intracranial Inflammatory Pseudotumor: A Case Report and Review of the Literature

Inflammatory pseudotumors are lesions characterized by inflammatory cell infiltration and fibrosis. Central nervous system (CNS) inflammatory pseudotumors are much rarer, and generally manifest in the sellar and parasellar regions. We report a patient with an inflammatory pseudotumor in the temporal and occipital lobes treated in our department in 2017, and present a literature review. We discuss the etiology, imaging, pathology, and treatment of intracranial inflammatory pseudotumors.
View complete article: PDF  |  Full-text

A Clinical Case Study of Paratesticular Rhabdomyosarcoma of Young Adult

Para-testicular rhabdomyosarcoma (RPT) is a rare tumor of children and adolescents. The diagnosis is made by the anatomopathological study. The treatment must be multimodal and involves surgery, chemotherapy and radiotherapy. We report the case of a 19-year-old adolescent in our department for an embryonic-type para-testicular rhabdomyosarcoma. Our aim is to expose a rare and unknown case that may be life-threatening. We would like to emphasize on the fact that paratesticular rhabdomyosarcoma need to be brought up in front of a tissular process expanding in the scrotum with normal testicules.
View complete article: PDF  |  Full-text

Granular Cell Tumor of the Tongue: 2 Cases Report and Review of the Literature

Granular cell tumor, also known as Abrikossoff tumor, is a rare lesion that arises from the nervous system. Most of these tumors are benign and only 1-2% are malignant. Although they can be found in any part of the human body, 45-65% appears in the head and neck region, mainly in the oral cavity. Here, we report 2 cases of granular cell tumor of the tongue, diagnosed by excisional biopsy. Until the present moment, both patients remain with no recurrence.
View complete article: PDF  |  Full-text

Importance of Complete Clinical History in the Management of Parakeratinized Odontogenic Keratocyst: Case Report

The Odontogenic Keratocyst considered potentially aggressive and of high recurrence located between 30 and 60%, with clinical and radiographic characteristics not clearly defined. It occurs at any stage of life. The 70 to 80% of the cases are located in the jaw, commonly in the area of the lower third molar and mandibular angle from where they progress towards the branch and the body. The lesions are long latent, often asymptomatic and can reach remarkable dimensions without significant deformation of the jaw bones. They are often found during the routine radiographic examination.
View complete article: PDF  |  Full-text

Monoclonal Antibodies for the CIGB-552 Antitumor Synthetic Peptide Quantification

The CIGB-552 peptide is a synthetic peptide that exerts cytotoxic effect on tumor cells. Thus, CIGB-552 peptide quantification in patient samples is crucial for assessing the treatment efficacy. Therefore, this study describes the generation and characterization of monoclonal antibodies (mAb) directed against the CIGB-552 peptide to be used in a quantification assay in further pharmacokinetic studies in humans. In this sense, the CIGB.552-H294 mAb specificity was evidenced only against the CIGB-552 peptide and a metabolite of 17 amino acids resulting from the CIGB-552 peptide degradation detected in mouse sera.
View complete article: PDF  |  Full-text

Profile of Tumor-Associated Cytokines among Breast Cancer Patients: A Preliminary Study

The link between disease and the oral cavity represent clinically important factors that have given rise to the interest in using saliva as a diagnostic fluid for systemic diseases. The objective of this study was to detect and quantify cancer related cytokines in the saliva of women with breast cancer and compare their concentrations to a healthy cohort.
View complete article: PDF  |  Full-text


Editorial Board Members Related to tumor

Douglas M. Coldwell

Professor
Radiology and Bioengineering
University of Louisville
United States

Marcelo L. Rodriguez-Puebla

Associate Professor
Department of Molecular Biomedical Sciences
North Carolina State University
United States

SONAL GUPTA

Assistant Professor
Department of Pathology
University of Texas MD Anderson Cancer Center
United States

Jason W. Locasale

Assistant Professor
Division of Nutritional Sciences
Cornell University
United States

Norhafiza Mat Lazim

Department of Otorhinolaryngology-Head & Neck Surgeon
School of Medical Sciences
Universiti Sains
Malaysia

Arif Gulzar

Department of Material Science and Chemical Engineering
Harbin Engineering University
China

CHRISTOPHER THOMAS WHITLOW

Associate Professor of Division of Radiologic Sciences
Department of Radiology
Wake Forest School of Medicine
United States

Suling Liu

Professor
School of Life Sciences
University of Science & Technology
China

Lina H K LIM

Associate Professor
Department of Physiology
National University of Singapore
Singapore

Marwa Hamdy El-Wakil

Faculty of Pharmacy
Pharmaceutical Chemistry Department
Alexandria University
Egypt
Submit Manuscript


Open Access Journals

View All Journals