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Articles Related to ESI

Effects of a Dietary Supplement Containing Salacia Extract, Citrus Bioflavono ids, and Trivalent Chromium on Markers of Glucose Control and Quality of Life: A Randomized, Placebo-Controlled, Double-Blind Study

The purpose of this investigation was to compare the efficacy of a combination of Salacia chinensis extract, citrus bioflavonoids, and trivalent chromium (SEC) on glucose and insulin control, psychobiological perceptions of hunger, and adverse events reported from 12 weeks of supplementation. Using a randomized, double-blind, placebo-controlled parallel group study design, subjects were randomized to consume SEC or a placebo (PLA). Participants completed two study visits (baseline and after 12 weeks of supplementation) where they were assessed for glucose and insulin changes after an oral su crose tolerance test (OSTT), perceptual indicators of hunger and appetite, waist circumference, and clinical biomarkers of metabolic and physiological function associated with glucose and insulin control. Twelve weeks of SEC supplementation sig nificantly reduced cravings for sweets, reduced insulin and glucose responses to an OSTT, and increased adiponectin levels. Improvements in BUN: creatinine ratio provides preliminary support for maintaining healthy kidney function. These re sults support the role of botanical supplements in improving outcomes associated with obesity, metabolic health and glu cose intolerance.
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Effects of a Dietary Supplement Containing Salacia Extract, Citrus Bioflavonoids, and Trivalent Chromium on Markers of Glucose Control and Quality of Life: A Randomized, Placebo-Controlled, Double-Blind Study

The purpose of this investigation was to compare the efficacy of a combination of Salacia chinensis extract, citrus bioflavonoids, and trivalent chromium (SEC) on glucose and insulin control, psychobiological perceptions of hunger, and adverse events reported from 12 weeks of supplementation. Using a randomized, double-blind, placebo-controlled parallel group study design, subjects were randomized to consume SEC or a placebo (PLA). Participants completed two study visits (baseline and after 12 weeks of supplementation) where they were assessed for glucose and insulin changes after an oral su crose tolerance test (OSTT), perceptual indicators of hunger and appetite, waist circumference, and clinical biomarkers of metabolic and physiological function associated with glucose and insulin control. Twelve weeks of SEC supplementation sig nificantly reduced cravings for sweets, reduced insulin and glucose responses to an OSTT, and increased adiponectin levels. Improvements in BUN: creatinine ratio provides preliminary support for maintaining healthy kidney function. These re sults support the role of botanical supplements in improving outcomes associated with obesity, metabolic health and glu cose intolerance
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A New Type of Anesthesia for Endovascular Abdominal Aortic Aneurysm Repair: 3 Cases Report

Choice of anesthetic approach for patients undergoing endovascular abdominal aortic aneurysm repair (EVAR) remains a challenge to the anesthetist, especially in emergency situations and for patients having multiple diseases. Although two main types of anesthetic techniques including general anesthetic (GA) and local anesthetic (LA) are used in EVAR, little is known about the effects of a combination method. Hence, we report a new combination anesthetic method used for 3 cases who are having multiple basic diseases (cardiovascular or lung) or with complex surgical procedure. The relevant anesthetic proce dure was firstly anesthesia induction with midazolam, sufentanil, etomidate, rocuronium and methylprednisolone. After in duction of GA and tracheal intubation, LA with 2% lidocaine combined with midazolam for sedation monitored anesthesia care (MAC) was maintained till to the end of the operation. Importantly, propofol and remifentanil were not injected with micropumps, muscle relaxants were not used, and anesthetics were not inhaled to maintain anesthesia. The depth of anesth esia was determined by Bis value and kept at the level of 40-60 during the operation. All patients cured and have completed one year follow-up. The benefits of using the method include: 1) increasing analgesic effect of LA mode and preventing pa tient body from moving and vasospasm occlusion caused by patient stress during LA procedure; 2) reducing the adverse re actions of GA drugs on cardiovascular and cerebrovascular systems therefore maintaining intraoperative hemodynamic sta bility. It is concluded that our method provides a new and valuable anesthetic consideration for emergency and complex en dovascular repair surgery
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A Study Discovered the Role of Carbon Dioxide in the Pathogenesis of Autoimmune Disorders

The incidence of autoimmune disorders has increased with the rise in carbon dioxide since last century. Objective: To determine whether CO2 is associated with autoimmune disorders. Design: Case-control study at local tertiary hospitals in Egypt. Method: A total of 150 patients with various autoimmune disorders, and 75 controls were aged 20 to 70 years. The exclu sion criteria were neuromuscular disorder, critical, respiratory illness, and exposure to CO2, guided by the criteria of the National Institute for Occupational Safety. Patients recruited from November 2023 to March 2024, matched by age, sex, and other demographic variables. All participants were tested for blood gases. Certain cases were further tested to confirm the autoimmune status. Pa CO2 analysis performed using two methods of statistical significance to validate data. Results: Pa CO2 (Mean ± SD) was (48.18 ± 12.10) in autoimmune cases, compared to (42.63 ± 11.06) in control (p= 0.001), number (%) of cases with ↑PaCO2= 97(64.7%) for cases, and 30(40%) for control (RR=1.6167). OR (95% CI) = 2.7453 (1.552 to 4.857), p=0.0005
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Prevalence of Overweight and Obesity and Associated Factors among School Aged Children in Bonga Town, Southwest Ethiopia, 2023

Background: Overweight and obesity is defined as the accumulation of excessive fat in the body of children. Even though childhood overweight and obesity are not yet supposed to be an emerging health issue in Ethiopia, their preva lence increases. The magnitude of overweight and obesity in the Southwest region, particularly in Bonga town is un known. Hence, the study aimed to assess the prevalence of overweight and obesity among school-aged children in Bonga town, Southwest Ethiopia
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Fertility Desire and Associated Factors among Women on Anti-Retroviral Therapy in the Lideta Sub-City Health Centers

This study examines fertility desires among women receiving antiretroviral therapy (ART) at Lideta Sub-City Health Centers in Addis Ababa, Ethiopia. A cross-sectional study was conducted with 397 women, achieving a response rate of 97.5%. Data was collected through structured interviews and analyzed using logistic regression to identify factors associated with fertility desire. The results showed that 76.6% of respondents desired fertility in the future, with relationship desire being associated with a lower likelihood of having fertility wishes. College-educated individuals over 55 (13.9%) were 10.24 times more likely to aspire to become parents than primary and uneducated individuals. Respondents preferred a time frame of three to four years. The average age of participants was 37.34 ± 7.20 years, with 43.1% aged 30–39 and 41.8% aged 40–49. Nearly half (49.4%) were married, and the majority (98.2%) lived in urban areas. Factors significantly associated with fertility desire included higher education, partner's desire for children, and preferred timing for live birth within 3-4 years. Married women were less likely to desire fertility. The findings suggest the need for targeted reproductive health counseling, partner involvement in family planning, and support tailored to women with higher educational backgrounds to effectively address their fertility aspirations. Interventions should focus on enhancing reproductive health counseling, involving partners in family planning,and providing targeted support to women with higher educational backgrounds.
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Unlocking Neurodegeneration: Scaffold-Derived Blockers of MAO-B and AChE Inspired by Bryophyllum pinnatum: A Structural Exploration

This study evaluates the potential of Bryophyllum pinnatum ligands as treatments for Alzheimer's disease (AD) and Parkinson's disease (PD) by targeting acetylcholinesterase (AChE) and monoamine oxidase B (MAO-B), enzymes linked to these neurodegenerative disorders. Utilizing Schrödinger Suite and Maestro 12.8 for computer-aided drug design, ligands from B. pinnatum and standard drugs were docked into the active sites of AChE and MAO-B. Further analysis included ADMET screening and MM/GBSA calculations, with pharmacophore modeling to align compounds with reference ligands. The study identified 4 and 6 promising compounds as MAO-B and AChE inhibitors, respectively. Pinoresinol was identified as the most promising candidate, exhibiting optimal binding, favorable blood-brain barrier permeability, and pharmacophoric features similar to those of the standard drug. These findings suggest the neuroprotective capabilities of B. pinnatum ligands, recommending further in vivo and in vitro testing to confirm their therapeutic efficacy
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Effect of Selected Fodder Intervention on Milk Yield in Friesian Dairy Cows in Selected Counties in Kenya

Over three decades, the mean daily milk production per cow in these regions has remained stagnant at a mere 6 kg/day with most smallholder farmers yielding a mere 3.67 litres of milk per cow daily, it's evident that their productivity falls well below par. In an effort to address this issue, a study conducted delves into the second objective, which revolves around assessing the effects of diverse dietary supplements on milk yield across the distinct geographical areas of Nyandarua, Bomet, and Nyeri. The study involved the utilization of a supplementary feed mixture which was 400 g/kg DM of dry matter content, comprising; lucerne, greenleaf desmodium, sweet potato vines, and chicory, which was chopped and mixed in a ratio of 1:2:3:1. Supplementation was done at the following inclusion levels; T1 (0%), T2 (10%), T3 (20%) and T4 (30%) of the estimated daily dry matter intake of 4% of the live body weight of the dairy cow. A basal diet of boma Rhodes which was 400 g/kg DM of dry matter content was used. This study ran for nine weeks in each region; one week of backgrounding all the animals, followed by fourteen days of adaptation and a month and a half of data collection. The research scrutinizes the outcomes of milk production resultant from diets featuring supplementation levels ranging from 10% to 30% in Friesian dairy cows. The findings reveal that, in Bomet, There isn't a significant variation in milk production between diets exhibiting 10% and 30% supplementation, suggesting a potential plateau in response to heightened supplementation levels. Conversely, in Nyandarua, diets supplemented with 20% and 30% show no significant variance in milk yield, spotlighting the efficacy of a moderate supplementation level. In Nyeri, noteworthy disparities in milk yield emerge between diets with 10% and 30% supplementation levels
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Biofilm and Extended Spectrum Beta Lactamase (ESBL) Producing Multi Drug Resistant Bacterial Uropathogens: A Challenge to Antibiotic Therapy in Nepal

Background: Urinary tract infection is one of the most common bacterial infections encountered by clinicians in developing countries. A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix consisting of polysaccharide, protein and DNA. Antibiotic resistance is a problem of deep scientific concern both in hospital and community settings. This study was aimed to determine the biofilm producers among multidrug uropathogenic bacteria isolated from urine cultures
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Characterizations of Cu2FeSnSe4 Thin Films Synthesized from Nanoparticles Powder

Cu2FeSnSe4 (CFTSe) thin film were synthesized on glass substrate by thermal evaporation method at Ts=400° C, starting from elemental powders mixed by a mechanical alloying process. The structural, morphological, compositional, optical and electrical properties of CFTSe semiconductor have been investigated by X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray analysis (EDAX), spectroscopic ellipsometry (SE) and Van Der Pauw technique, respectiv
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In-vitro Regeneration in Maize (Zea Mays L.) from Mature Embryo

Maize is an economically important crop worldwide. As the world population increases, there is a great need to develop high yielding and stress resistant maize varieties. To provide a future platform for maize improvement, we tested mature embryos as alternative explants for the regeneration of three economically important maize inbred lines: CML331, CML442 and CML444.
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Haosmc Growth on Various Sustainable Nano/Micropatterned Surface Topographies Utilising Reusable Surface Templatin

The aim of controlling/regulating cellular processes by surface patterning of biomaterials is a crucial concept in emerging research fields, where the precise fabrication of micro-nano surface topographies is required at manufacturing scales to meet consumer demand. Photolithography is typically employed for surface patterning; however, the high cost, process complexity, and lack of environmentally friendly and sustainable methodologies represent steep barriers for many researchers. Soft lithographic methods have been utilised extensively as a potential alternative for traditional photolithography, yet a photolithographic step is still required for initial template fabrication. Here, we demonstrate the use of repurposed optical consumer items such as DVDs, diffraction glasses, and gratings that would otherwise be thrown away after their useful lives, being used here as a sustainable approach as templates for the formation of complex nano-patterns. By replicating these templates in polydimethylsiloxane (PDMS) and polylactic acid (PLA), we show the varied interactions of human aortic smooth muscle cells (HAoSMC) to these surfaces. Notably, it was demonstrated that, in comparison to nonpatterned substrates, HAoSMC interaction (adhesion, spreading, and viability) was higher on DVD patterned surfaces compared to diffraction glass and grating patterned surfaces according to the results from cell metabolic activity (MTT and Alamar Blue), and proliferation (total DNA) assays. We demonstrate that a simple, reusable, inexpensive, yet robust technology could be a powerful tool in improving our understanding of cell-surface interactions and for the potential development of medical devices with micro- and nanoscale low or high adhesion features
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Effect of “BEAUTYCOFFEE” on Body Weight A Pilot Study in Patients with Obesity

Background and Aims: Obesity and overweight are associated with a wide spectrum of morbid conditions, which contribute to high prevalence of disability and mortality worldwide. These conditions include the metabolic syndrome, cardio-- vascular and cerebro-vascular events, and fatty liver disease with the possible deterioration to liver fibrosis, cirrhosis and malignancy. Despite the wide variety of treatment options available, which include lifestyle modifications and medical and surgical interventions, obesity is still considered a worldwide pandemic, necessitating the search for additional treatment options. As caffeine exerts weight-reducing properties, we here studied the effect of Beautycoffee, a dietary supplement composed of black and green coffee arabica, together with herbal compounds, believed to be effective towards decreasing body weight.
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Transgenic Expression of Sugarcane Mosaic Virus VPg in Maize Inbred Line CML444 Confers Resistance to Maize Lethal Necrosis Disease

Maize is the most important crop in Kenya and parts of Sub-Saharan Africa. However, yields are below potential due to abiotic and biotic constraints. One of the major biotic concerns is maize lethal necrosis disease (MLN), which causes up to 100% yield losses. MLN is caused by the synergistic infection of two viruses, Maize chlorotic mottle virus (MCMV) and a potyvirus, commonly Sugarcane mosaic virus (SCMV)
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Mathematical Analysis on the Design of Heliostat Field

The optimal design of heliostat field in solar power generation device is studied Heliostat field generates high temperature by focusing the sunlight reflected from the mirror surface, thus pushing the turbine to generate electricity. In order to improve the efficiency of power generation, this paper optimizes the parameters of heliostat field, establishes a singleobjective optimization model, and uses mixed strategy whale optimization algorithm to solve it. Through geometric optical analysis and ray tracing model, the optical efficiency of heliostat field and the annual average output thermal power per mirror area are calculated. Finally, through the discussion and analysis of the model, the optimization design method is evaluated.
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Anodizing for Design and Function

Two basic reactions occur during the anodizing of aluminum: 1) the aluminum is consumed and 2) an oxide grows. By accepting this statement as true, the anodizing process can be viewed as a corrosion process, and anodizing can be modeled using the Tafel Equation. Anodizing process parameters of electrolyte chemistry and concentration, temperature, aluminum substrate resistance and current density are presented as they relate to the Tafel Equation and how they impact the anodic aluminum oxide structure and properties. Understanding this relationship is consequent in making anodizing an engineering process, one that enables tuning the structure such that it yields distinct characteristics to fulfill design and application requirements.
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Synthesis of BaTiO3 Nanowires via Anodic Aluminum Oxide Template Method Assisted by Vacuum-and-Drop Loading

In this paper, we report on the synthesis of BaTiO3 nanowires via the anodic aluminum oxide template method. To fill in the precursors of BaTiO3 into anodic aluminum oxide templates, the vacuum and drop loading method developed in our previous study was used. Ba(CH3COO)2 (barium acetate) and C12H28O4Ti (tetraisopropyl orthotitanate) were used as Ba and Ti sources, respectively. Anodic aluminum oxide membranes with the through-hole diameter of ~200 nm were used as the template for BaTiO3 nanowires.
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Editorial Board Members Related to ESI

Yanni Sun

Assistant Professor
Department of Computer Science and Engineering
Michigan State University
United States

MICHAEL VAN DOREN JOHNSTON

Professor
Department of Neurology and Pediatrics
Johns Hopkins University School of Medicine
United States

K. RAMANATHAN

Associate Professor
Industrial Biotechnology Division
School of Bio Sciences and Technology
VIT University
INDIA

WILLIAM FRAZER MORRIS

Professor
School of Osteopathic Medicine
Campbell University
United States

Mehdi Razzaghi-Abyaneh

Professor and Head
Department of Mycology
Pasteur Institute of Iran
Iran

Suresh G. Joshi

Associate Professor
Department of Microbiology and Immunology
Drexel University
United States

Mehmet SARIER

Assistant professor
Department of Urology
Altinbaş University
Medical Park Hospital
Turkey

Hazem Aqel

Professor
College of Applied Medical Sciences
King Saud Bin Abdulaziz University for Health Sciences
Saudi Arabia

Shuvra Kanti Dey

Assistant Professor
Department of Microbiology
Jahangirnagar University
Bangladesh

Rebecca Cogwell Anderson

Professor
Department of Anesthesiology
Medical College of Wisconsin
United States
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