Top Links

Articles Related to Fto

Elexacaftor/Tezacaftor/Ivacaftor Improves Glycemic Control in Pediatric Patients with Cystic Fibrosis-Related Diabetes

Cystic fibrosis (CF) is an inherited disorder caused by genetic mutations encoding the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) is a CFTR modulator shown to improve lung function in certain patients with CF. We undertook this study to determine its effects on glycemic outcomes in pediatric patients with cystic fibrosis-related diabetes (CFRD). We reviewed the medical records and identified two subjects, referred to as subject A and subject B, with CFRD on insulin therapy at Duke University Hospital between 2019-2020 who were on treatment with ELX/TEZ/IVA for at least one year. The mean hgbA1C pre- and post- treatment was 5.65% (5.6-5.7) and 5.05% (5.0-5.1) respectively with a mean reduction of 0.6% (p value 0.01). Improvement in hgbA1C occurred in the absence of increased insulin requirements, subject B remained on a similar insulin regimen whereas subject A was able to come off insulin completely. In addition, improvements in BMI z-score were seen in both groups with a mean BMI z-score of -0.30 pre-treatment (-0.71-0.11) and z-score of +0.28 post-treatment (0.11-0.45).
View complete article: PDF  |  Full-text

Characterization of Screen-Printed Nickel Oxide Electrodes for p-type Dye-Sensitized Solar Cells

Mesoporous NiO films obtained via screen-printing deposition of a newly formulated paste containing preformed NiO-nanospheres have been employed as nanostructured photocathodes of p-type dye-sensitized solar cells (p-DSCs).
View complete article: PDF  |  Full-text

m6a RNA Methylation: The Implications for Health and Disease

The recent resurgence of interest in m6A has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification. The m6A modification is a highly reactive and fluid modification which can respond rapidly to a broad variety of stimuli, and translate these signals into cellular activity. The little information that has been established on its functional capacity has opened up many new avenues of research and has tremendous implications for several fields of study.
View complete article: PDF  |  Full-text


Editorial Board Members Related to Fto

Clifton L Smith

Professor
Electron Science Research Institute
Edith Cowan University
Australia

RAVINDRA K. MALIK

Professor
Natural and Forensic Sciences Department
Albany State University
United States
Submit Manuscript