Articles Related to Injury

Purpose: We aimed to create mechanic optic nerve injury model in rats and investigate the neuroprotective effects of ripasudil on retinal ganglion cells. Study Design: Experimental study Methods: Mechanic optic nerve injury model was created in the right eyes of male Wistar rats (n=15). Rats were divided into three groups: glaucoma model with sham treatment (group1) and 20 µM intravitreal ripasudil treatment (group 2) and 50 µM intravitreal ripasudil treatment (group 3). Treatment was applied intravitreally and rats were sacrificed at the end of 4 weeks. Glial fibrillary acidic protein (GFAP), Brn-3a antibody,anti- Iba1 was examined by immunohistochemistry. Results: The number of Brn-3a positive RGC in the mechanical optic nerve injury model was 5.33 ± 2.08 (min: 3, max: 7) in sham group, 10.25 ± 2.63 (min: 8, max: 14) in 20 µM group and 16.75 ± 5.43 (min:9, max: 21) in 50 µM group (p <0.05). GFAP positive RGC counts were recorded as 24.33 ± 2.08 (min: 22, max: 26) in sham group, 16.75 ± 1.70 (min: 15, max: 19) in 20 µM group and 13.00 ± 4.08 (min:10 , max: 19) in 50 µM group (p <0.05). Ripasudil treatment also decreased Iba1 expression in the retina of mechanic optic nerve injury groups. In addition, ripasudil treatment prevented apoptotic cell death by increasing Bcl-xL protein expression and preserved Tfam protein expression in the retina. Conclusions: Our experimental study has shown that ripasudil is neuropreotective in mechanical optic nerve injury model.

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Dengue is a prevalent arthropod-borne viral disease in tropical and subtropical areas of the globe. Dengue clinical manifestations include asymptomatic infections; undifferentiated fever; dengue fever, which is characterized by fever, headache, retro orbital pain, myalgia, and arthralgia; and a severe form of the disease denominated dengue hemorrhagic fever/dengue shock syndrome, characterized by hemoconcentration, thrombocytopenia, and bleeding tendency. However, atypical manifestations, such as liver, central nervous system, and cardiac involvement, have been increasingly reported called expanded dengue syndrome. The renal complications of dengue virus infection cover a wide spectrum of manifestations from acute kidney injury to glomerular injury with nephritic/nephrotic syndrome. Majority of cases remain symptom free and show full recovery. We report a 55 years old lady with atypical and rare presentation of dengue disease marked by rapidly progressive glomerulonephritis. Condition improved after initial 5 days pulse methylprednisolone followed by oral prednisolone therapy and mycophenolate mofetil. The main mechanism of dengue glomerulonephritis is still unknown though both direct viral infection and immune mediated damage have been suggested to be the cause. To avoid otherwise preventable morbidity and mortality, physicians should have a high index of suspicion for renal complications in patients with dengue illness and should manage this accordingly

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Lower urinary tract injury in hysterectomy is rare, but once it occurs, the consequence can be deteriorating. We experienced late onset urinary tract injury that developed as late as 15 days after laparoscopic hysterectomy. The objective of this case report is to alert all gynecological laparoscopists that such late onset complication may happen to any of patients.

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Diffuse midline gliomas with the histone 3-lysine-27-methionine (H3K27M) mutation should be considered in the differential diagnosis of recurrent hemiparesis and headache in patients with midline brainstem lesions, even with the absence of contrast-enhancement. Early diagnosis is essential for prognostication and engagement in trials evaluating novel therapeutics such as ONC-201.

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We report 2 cases of severe injuries in patients with sleep disorders. The first patient sustained multiple orthopedic traumas as sequelae of REM sleep behavior disorders (RBD). The second patient sustained a severe TBI as a result of restless legs syndrome (RLS). To our knowledge, there are only 2 reported cases of severe orthopedic traumas (cervical spine fractures) as a result of RBD and no reported cases of severe TBI from RLS.

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The victims of intimate partner violence are subjected to emotional, physical and/or sexual abuse. The physical abuse often includes episodes of mechanical asphyxia and its most frequent mechanisms: throttling and strangulation. Non-fatal asphyxia situations have signs, symptoms and short-term or long-term consequences whose severity varies according to the intensity, duration and number of episodes.

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Kidney injury has been observed broadly in severe and critical coronavirus disease 2019 (COVID-19) patients, but the impairment of renal function in ordinary cases has rarely reported. We conducted this study to explore whether patients in ordinary condition suffered from kidney injury during the course of COVID-19 and to find out a proper indicator for detecting kidney injury in COVID-19 patients.

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The aim of this study was to compare and determine the feasibility, surgical outcomes, intraoperative and postoperative complications of the use of the posterior approach technique in the laparoscopic radical hysterectomy (LRH) to the conventional laparoscopic radical hysterectomy in patients with cervical cancer.

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Spinal cord injury (SCI) is trauma to the area of the vertebrae resulting in spinal cord lesions resulting in neurological disorders, depending on the location of the spinal nerve damage and the injured nerve tissue. The symptoms of SCI can range from pain and paralysis to incontinence. SCI due to trauma is estimated to occur in 30-40 per million population per year, and about 8,000- 10,000 sufferers each year; generally, occurs in adolescents and young adults. Although the annual incidence of events is relatively low, the cost of care and rehabilitation for spinal cord injuries is very high, at around US $ 53,000 / patient.

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The World Health Organization declared COVID-19 a pandemic in March 2020 and since then COVID-19 infection has been reported in all parts of the world. Several Healthcare systems reduced or canceled none emergency or urgent surgeries to effectively manage the pandemic. Recently, the reported incidence of new cases of COVID-19 has reduced in some regions and some Healthcare systems are resuming elective gynecologic surgery. This narrative review explores the challenges of planning and resuming elective gynecologic surgery in a climate of continuing community transmission.

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Cognitive impairment post TBI is an important factor in rehabilitation outcomes. Pharmacological and therapeutic services do not directly address damage to the cortical infrastructure. Hyperbaric Oxygen Therapy is known to improve brain function and healing.

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Bruises are due to the blood leaking from vessels into the dermis. They usually occur at sites exposed to trauma, mainly the lower limbs, outer hips and arms. Spontaneous bruising (purpura and ecchymoses) restricted to the face, neck and chest are an exception to the rule.

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Microalbuminuria reflects rapid changes in glomerular permeability and is associated with systemic capillary permeability.

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To report on the effect of electrical stimulation of the cervical spine while recording muscular signal from lower limb muscles with Cervical Multisegmental Motor Responses (MMR).

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Blunt force trauma resulting in a combination of serious injuries is a significant cause of morbidity and mortality. We present a successfully managed case of blunt force trauma from a motor vehicular collision resulting in concomitant blunt abdominal aortic injury (BAAI) and multiple traumatic abdominal wall hernias (TAWH) that required emergency surgery.

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