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Articles Related to MELB

Assessment of Antioxidant and Antineoplastic Activities Blumea Lacera (Burn. F) Leaves

Blumea lacera (Burn. f.) DC. (Family: Asteraceae) is an important member of Bangladeshi natural plant resource and it is an herbaceous weed locally known as Kukursunga. Different parts of this plant are used traditionally to cure various diseases. But detail study on the antioxidant and antineoplastic potentials of Blumea lacera leaves, has not yet been done. Aim of this study is to examine the antioxidant and antineoplastic properties and quantify the different type of phytochemical content of the methanolic extract of leaves of Blumea lacera (MELB). MELB contained a rich polyphenol, flavonol, flavonoid and proanthocyanidins. MELB showed moderate cytotoxic effect against Artemia salina (brine shrimp nauplii) where its LD50 values was 66.12 μg/ml. In vitro antioxidant assay, MELB exhibited a remarkable capacity to scavenge the tested reactive species. MELB scavenged DPPH with an IC50 of 33.64 μg/mL and 42.69 μg/mL, respectively. In vivo antineoplastic assay, MELB significantly (P<0.05) decreased viable cell count and increased the survival time of EAC cell bearing mice. Hematological profiles were also restored significantly (P<0.05) to normal levels in MELB treated mice as compared to untreated EAC control mice. In addition, fluorescence microscopic view of EAC cells derived from MELB-treated group showed apoptotic characteristics in treated cells compared to untreated EAC control. our findings suggest that methanolic extract of Blumea lacera leaves(MELB) might be a potential agent with antioxidant properties for prevention of cancer and has the merit for further investigation in isolating its active constituents.
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Editorial Board Members Related to MELB

Fathinul Fikri Ahmad Saad

Senior lecturer
Centre for Diagnostic Nuclear Imaging
University Putra Malaysia
Malaysia

PRABHAKARAN

Professor
Department of Surgery
National University of Singapore
Singapore

Douglas Wilson

Professor
School Medicine Pharmacy and Health
Durham University
UK

INTAN HAKIMAH ISMAIL

Associate Professor
Department of Paediatrics
Faculty of Medicine and Health Sciences (FMHS)
University Putra Malaysia
Malaysia

Prof. Dr. Alireza Heidari, Ph.D., D.Sc.

Full Distinguished Professor and Academic Tenure of Chemistry. Enrico Fermi Distinguished Chair in Molecular Spectroscopy. Head of Cancer Research Institute (CRI). Director of the Bio Spectroscopy Core Research Laboratory (BCRL) at Faculty of Chemistry, California South University (CSU), Irvine, California, USA. President of the American International Standards Institute (AISI), Irvine, California, USA. Board Member of the World Association of Theoretical and Computational Chemists (WATOC).

Doug Fairlie

Division of Structural Biology
The Walter and Eliza Hall Institute of Medical Research
Australia

Sheila Crewther

Professor
School of Psychological Science
Univerity of La Trobe
Australia
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