Articles Related to Microarray

DNA Methylation Status of the Methylenetetrahydrofolate Reductase Gene is associated with Depressive Symptoms in Japanese Workers: A Cross-Sectional Study

Polymorphisms in methylenetetrahydrofolate reductase (MTHFR) gene, that is considered to be the most important genetic determinant of blood homocysteine concentration, are associated with various diseases, including psychiatric disorders. However, the epigenetic factors influencing on the transcription and expression of this gene are unclear.

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Modifying the Classical F Test for Microarray Experiments

Microarray data has a high dimensional data structure that makes statistical inference drawn from this type of data challenging. Since current statistical methods are generally for “small p and large n”, these methods can be insufficient to draw valid conclusions for microarray data.

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Epigenetic Changes Caused by Occupational Stress in Humans Revealed through Noninvasive Assessment of DNA Methylation of the Tyrosine Hydroxylase Gene

Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of L-dihydroxyphenylalanine (L-DOPA), a precursor of dopamine, and is considered to be involved in many aspects of mental health. On the other hand, the epigenetic mechanisms have been recognized as mediators of stable changes in brain function.

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