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Articles Related to Nucleotide

Xeroderma Pigmentosum Groups C and A in Algerian Patients with Deregulation of both Transcription and DNA Repair

Xeroderma Pigmentosum (XP) is a rare autosomal recessive disorder characterized by an extreme sensitivity to UV rays from sunlight, a high incidence of skin cancer and occasional neurological symptoms. XP, primarily defined as a DNA repair syndrome, has been found associated with defects in the Nucleotide Excision Repair (NER) pathway, and more recently by transcriptional deregulation. XP results from mutations in eight genes (XPA to XPG and XPV) coding for proteins involved in NER.
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Relationship of YWHAH Single Nucleotide Polymorphisms to Markers of Rheumatoid Arthritis Disease Severity

Introduction: Serum 14-3-3 eta provides diagnostic and prognostic information in Rheumatoid Arthritis (RA). It is coded by the YWHAH gene with single nucleotide polymorphisms (SNPs) linked to bipolar disorder and schizophrenia. It was hypothesized that 6 previously described YWHAH SNPs might relate to markers of RA disease severity such as seropositivity or erosive changes. Association study performed at an academic hospital Rheumatology Clinic. Subjects studied were 18 years of age or older with RA. TaqMan analysis screened for YWHAH SNPs rs2246704, rs2853884, rs3747158, rs4820059, rs7291050, rs933226. Primary endpoint was presence of at least one copy of the YWHAH SNPs with the markers of RA disease severity.
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Cloning of Perilipin 2 Gene and Investigating its Expression Level in Porcine Longissimus Muscle

PLIN2 belongs to one member of PAT (Perilipin, Adipophilin and Tip47) family, which plays an important role in regulating lipid storage and could be regarded as a candidate gene for intramuscular fat deposition in pigs. This study tried to clone the coding domain sequence (CDS) of PLIN2 gene, compare the nucleotide acids and deduced amino acids sequence, physiological characteristics, structure and the expression level between Wujin (fatty breed) and Landrace (lean breed) pigs. The results showed that the mutation of nucleotide acids led to the mutation of deduced amino acids between two pig breeds.
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An Introduction to the Approaches of Novel Drug Delivery Systems for Acquired Immune Deficiency Syndrome (AIDS)

The currently available anti HIV agents have several drawbacks such as short half life, low bioavailability, poor CNS penetration and retention, hepatic first pass metabolism, undesirable side effects and frequent dosing regimen.
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Nanotechnology Approaches for Antiretroviral Drugs Delivery

The development of effective drug delivery approaches for the treatment of AIDS and HIV infection is a global challenge. The advent of multidrug, highly active antiretroviral therapy (HAART), have increased the life span of HIV-infected patients.
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Osteomyelitis of the Hip secondary to Aspergillus fumigatus - A Case Report and Comprehensive Review of the Literature

Aspergillus infection in an immunocompetent human host is a rare entity. In most cases it presents as an opportunistic pathogen in immunocompromised patients. The portal of entry is usually the respiratory tract or direct inoculation of the organism to the site. Aspergillus osteomyelitis is a debilitating and severe form of Invasive Aspergillosis.
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Molecular Mechanisms of Mismatch Repair Genes in Cancer – A Brief Review

The DNA mismatch repair (MMR) system is necessary for the maintenance of genomic stability. The MMR system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops (IDLs) and heterologies generated during DNA replication and recombination.
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Editorial Board Members Related to Nucleotide

Anthony Joseph Berdis

Assistant Professor
Departments of Chemistry and Biology
Cleveland State University
United States

Martin Falk

Head and Professor
Institute of Biophysics of ASCR
Czech Republic

Scott Asbill

Professor of Pharmaceutics
College of Pharmacy & Health Sciences
Campbell University
United States

Lin Feng

Associate Professor
Bioinformatics Research Centre
Nanyang Technological University
Singapore

Robert R. Redfield

Professor
Department of Immunology and Microbiology
University of Maryland
United States

Jurgen Konig

Professor
Department of Nutritional Sciences
University of Vienna
Austria

Rajat Subhra Das

Scientist
Omega Therapeutics
Cambridge
USA

Ajar Nath Yadav

Assistant Professor
Department of Biotechnology
Akal College of Agriculture, Eternal University
India
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