Articles Related to Osteoarthritis
Clodronate : A Potential DMOAD in Osteoarthtitis
Osteoarthritis is an inflammatory-degenerative joint disease that affects the osteochondral unit with the concomitant intervention of the immune system; this causes pain and progressive functional limitation. With a varied and complex etiopathogenesis, Osteoarthritis has a subtle outcome and an inexorable evolution towards joint deformity. The therapeutic
approach makes use of non-pharmacological and pharmacological aids. Pharmacological therapy consists of symptomatic
drugs that act on acute and especially chronic pain, in an attempt to decrease the incidence of any structural damage to the
cartilage and subchondral bone. If the anti-resorptive drugs cure the subchondral-epiphyseal osteometabolic pathology,
the interventions on the cartilage have not produced important and well evaluable results, even after prolonged therapies.
This contribution analyzes the profile of Clodronate, used for the treatment of subchondral bone edema in Osteoarthritis,
regarding its potential protective effects in cartilage, like DMOADs.
Ultrasound as a New Imaging Tool to Assess Pathological Change of Joints in Preclinical Mouse Models of Osteoarthritis
Murine osteoarthritis (OA) models are important for exploring OA pathology and treatment in the pre-clinical study. Longitudinal in vivo imaging modalities, including X-ray, computed tomography, and magnetic resonance imaging, are commonly used diagnostic tools in OA clinic, while end-point histomorphometry analysis is the major outcome measurement in the pre-clinical study because clinical imaging modalities have limited resolution for small animals.
Canakinumab in the Treatment of Erosive Hand Osteoarthritis: A Case Series
Erosive hand Osteoarthritis (EOA) is a common and debilitating form of hand OA for which there are no proven or efficacious therapies. Interleukin-1 beta (IL-1β) plays a prominent role in OA joint inflammation. Canakinumab is a selective IL-1β inhibitor.
Food Energy Cost of Overweight and Obesity: A Model to Estimate the Amount of Food Expended for Excess Body Weight in a Community
Over-consumption of food energy entails body fat accumulation, overweight, obesity and increased risks of diseases. It is also indirectly associated with poor body condition followed by forced rest periods and limitations of activities and tasks. At community or global level, excess body weight could indirectly influence the environment by advancing food demand and the pressure on food production resources.
Croscarmellose Sodium Efficiency in the Development of a Generic Capsule Formulation of Piroxicam, Comparable Dissolution Profile to the Innovator Product, Feldene
The objective of this study was to evaluate the encapsulation performance of Croscarmellose sodium, a superdisintegrant in a low-dose, poor-solubility drug formulation and the in-vitro dissolution performance of the Piroxicam capsules. Preparation, characterization and evaluation of the effects of the different concentrations of carmellose sodium and the amount of dried starch on in-vitro dissolution of Piroxicam capsules. Piroxicam was chosen for its very low solubility in biological fluids, which result in poor systemic bioavailability after oral administration. Piroxicam can be categorized as Class II drugs according to the Biopharmaceutics Classification System.
Anti-Arthritic Efficacy And Safety Of Crominex 3+ (Trivalent Chromium, Phyllanthus emblica Extract, And Shilajit) In Moderately Arthritic Dogs
The present investigation was undertaken to evaluate the therapeutic efficacy and safety of Crominex 3+ (a complex of trivalent chromium, Phyllanthus emblica (Amla) extract and purified Shilajit) in moderately arthritic dogs.
Anti-Inflammatory and Anti-Arthritic Efficacy and Safety of Purified Shilajit in Moderately Arthritic Dogs
The objective of this investigation was to evaluate the efficacy and safety of purified Shilajit in moderately arthritic dogs. Ten client-owned dogs in a randomized double-blinded study received either a placebo or Shilajit (500 mg) twice daily for a period of five months. Dogs were evaluated each month for physical condition (body weight, body temperature, heart rate, and respiration rate) and pain associated with arthritis (overall pain, pain from limb manipulation, and pain after physical exertion).
Topical Delivery System for Phytochemicals: Capsaicin and Capsicum Tincture
Capsaicin, an active ingredient of Capsicum fruit, is currently undergoing “revival” in the clinical management of pain. However, the choice of its formulation is rather limited to the use of “old-fashioned” tinctures and recently the patches. In an attempt to improve the therapeutic outcome and develop its skin-friendly formulation, we prepared the vesicle-based drug delivery system with capsaicin.
Editorial Board Members Related to Osteoarthritis
Charles J. Malemud
Professor
Department of Medicine and Anatomy
Case Western Reserve University
United States
Department of Medicine and Anatomy
Case Western Reserve University
United States
Muhammad Nasir Afzal
Professor & Director
Department of physiology
College of Medicine, Alfaisal University
Saudi Arabia
Department of physiology
College of Medicine, Alfaisal University
Saudi Arabia